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CD22 (CD22 molecule)

Identity

Alias_namesCD22 antigen
Alias_symbol (synonym)SIGLEC-2
SIGLEC2
Other alias
HGNC (Hugo) CD22
LocusID (NCBI) 933
Atlas_Id 972
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 35329169 and ends at 35347361 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SIPA1L3 (19q13.13) / CD22 (19q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)CD22   1643
Cards
Entrez_Gene (NCBI)CD22  933  CD22 molecule
AliasesSIGLEC-2; SIGLEC2
GeneCards (Weizmann)CD22
Ensembl hg19 (Hinxton)ENSG00000012124 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000012124 [Gene_View]  chr19:35329169-35347361 [Contig_View]  CD22 [Vega]
ICGC DataPortalENSG00000012124
TCGA cBioPortalCD22
AceView (NCBI)CD22
Genatlas (Paris)CD22
WikiGenes933
SOURCE (Princeton)CD22
Genetics Home Reference (NIH)CD22
Genomic and cartography
GoldenPath hg38 (UCSC)CD22  -     chr19:35329169-35347361 +  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD22  -     19q13.12   [Description]    (hg19-Feb_2009)
EnsemblCD22 - 19q13.12 [CytoView hg19]  CD22 - 19q13.12 [CytoView hg38]
Mapping of homologs : NCBICD22 [Mapview hg19]  CD22 [Mapview hg38]
OMIM107266   
Gene and transcription
Genbank (Entrez)AK026467 AK225625 AK225694 AK301177 BC109306
RefSeq transcript (Entrez)NM_001185099 NM_001185100 NM_001185101 NM_001278417 NM_001771 NM_024916
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD22
Cluster EST : UnigeneHs.579691 [ NCBI ]
CGAP (NCI)Hs.579691
Alternative Splicing GalleryENSG00000012124
Gene ExpressionCD22 [ NCBI-GEO ]   CD22 [ EBI - ARRAY_EXPRESS ]   CD22 [ SEEK ]   CD22 [ MEM ]
Gene Expression Viewer (FireBrowse)CD22 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)933
GTEX Portal (Tissue expression)CD22
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20273   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20273  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20273
Splice isoforms : SwissVarP20273
PhosPhoSitePlusP20273
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    Ig-like_dom    Ig-like_fold    Ig_sub    Ig_sub2   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)    Ig_2 (PF13895)   
Domain families : Pfam (NCBI)pfam08205    pfam13895   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)CD22
DMDM Disease mutations933
Blocks (Seattle)CD22
SuperfamilyP20273
Human Protein AtlasENSG00000012124
Peptide AtlasP20273
HPRD00114
IPIIPI00295133   IPI00218390   IPI00299450   IPI01013876   IPI00016577   IPI00975891   IPI00976481   
Protein Interaction databases
DIP (DOE-UCLA)P20273
IntAct (EBI)P20273
FunCoupENSG00000012124
BioGRIDCD22
STRING (EMBL)CD22
ZODIACCD22
Ontologies - Pathways
QuickGOP20273
Ontology : AmiGOprotein binding  plasma membrane  cell adhesion  integral component of membrane  carbohydrate binding  extracellular exosome  
Ontology : EGO-EBIprotein binding  plasma membrane  cell adhesion  integral component of membrane  carbohydrate binding  extracellular exosome  
Pathways : KEGGCell adhesion molecules (CAMs)    Hematopoietic cell lineage    B cell receptor signaling pathway   
NDEx NetworkCD22
Atlas of Cancer Signalling NetworkCD22
Wikipedia pathwaysCD22
Orthology - Evolution
OrthoDB933
GeneTree (enSembl)ENSG00000012124
Phylogenetic Trees/Animal Genes : TreeFamCD22
HOVERGENP20273
HOGENOMP20273
Homologs : HomoloGeneCD22
Homology/Alignments : Family Browser (UCSC)CD22
Gene fusions - Rearrangements
Fusion : MitelmanSIPA1L3/CD22 [19q13.13/19q13.12]  [t(19;19)(q13;q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD22 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD22
dbVarCD22
ClinVarCD22
1000_GenomesCD22 
Exome Variant ServerCD22
ExAC (Exome Aggregation Consortium)CD22 (select the gene name)
Genetic variants : HAPMAP933
Genomic Variants (DGV)CD22 [DGVbeta]
DECIPHERCD22 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD22 
Mutations
ICGC Data PortalCD22 
TCGA Data PortalCD22 
Broad Tumor PortalCD22
OASIS PortalCD22 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD22  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD22
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD22
DgiDB (Drug Gene Interaction Database)CD22
DoCM (Curated mutations)CD22 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD22 (select a term)
intoGenCD22
Cancer3DCD22(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM107266   
Orphanet
MedgenCD22
Genetic Testing Registry CD22
NextProtP20273 [Medical]
TSGene933
GENETestsCD22
Target ValidationCD22
Huge Navigator CD22 [HugePedia]
snp3D : Map Gene to Disease933
BioCentury BCIQCD22
ClinGenCD22
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD933
Chemical/Pharm GKB GenePA26201
Clinical trialCD22
Miscellaneous
canSAR (ICR)CD22 (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD22
EVEXCD22
GoPubMedCD22
iHOPCD22
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:27:22 CEST 2017

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