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CD226 (CD226 molecule)

Identity

Alias (NCBI)DNAM-1
DNAM1
PTA1
TLiSA1
HGNC (Hugo) CD226
HGNC Alias symbDNAM-1
DNAM1
PTA1
TLiSA1
HGNC Previous nameCD226 antigen
LocusID (NCBI) 10666
Atlas_Id 46470
Location 18q22.2  [Link to chromosome band 18q22]
Location_base_pair Starts at 69853274 and ends at 69956799 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SMAD2 (18q21.1) / CD226 (18q22.2)SMAD2 18q21.1 / CD226 18q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(14;19)(q11;q13) TRA/NECTIN2
t(14;19)(q32;q13) IGH/Various Partners


External links

 

Nomenclature
HGNC (Hugo)CD226   16961
Cards
Entrez_Gene (NCBI)CD226    CD226 molecule
AliasesDNAM-1; DNAM1; PTA1; TLiSA1
GeneCards (Weizmann)CD226
Ensembl hg19 (Hinxton)ENSG00000150637 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150637 [Gene_View]  ENSG00000150637 [Sequence]  chr18:69853274-69956799 [Contig_View]  CD226 [Vega]
ICGC DataPortalENSG00000150637
TCGA cBioPortalCD226
AceView (NCBI)CD226
Genatlas (Paris)CD226
SOURCE (Princeton)CD226
Genetics Home Reference (NIH)CD226
Genomic and cartography
GoldenPath hg38 (UCSC)CD226  -     chr18:69853274-69956799 -  18q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD226  -     18q22.2   [Description]    (hg19-Feb_2009)
GoldenPathCD226 - 18q22.2 [CytoView hg19]  CD226 - 18q22.2 [CytoView hg38]
ImmunoBaseENSG00000150637
Genome Data Viewer NCBICD226 [Mapview hg19]  
OMIM605397   
Gene and transcription
Genbank (Entrez)AJ537553 AK313199 BC074787 DB224741 GU935335
RefSeq transcript (Entrez)NM_001303618 NM_001303619 NM_006566
Consensus coding sequences : CCDS (NCBI)CD226
Gene ExpressionCD226 [ NCBI-GEO ]   CD226 [ EBI - ARRAY_EXPRESS ]   CD226 [ SEEK ]   CD226 [ MEM ]
Gene Expression Viewer (FireBrowse)CD226 [ Firebrowse - Broad ]
GenevisibleExpression of CD226 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10666
GTEX Portal (Tissue expression)CD226
Human Protein AtlasENSG00000150637-CD226 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15762   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15762  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15762
PhosPhoSitePlusQ15762
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD226    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_sub2    Ig_V-set   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)CD226
PDB (RSDB)6ISB    6O3O   
PDB Europe6ISB    6O3O   
PDB (PDBSum)6ISB    6O3O   
PDB (IMB)6ISB    6O3O   
Structural Biology KnowledgeBase6ISB    6O3O   
SCOP (Structural Classification of Proteins)6ISB    6O3O   
CATH (Classification of proteins structures)6ISB    6O3O   
SuperfamilyQ15762
AlphaFold pdb e-kbQ15762   
Human Protein Atlas [tissue]ENSG00000150637-CD226 [tissue]
HPRD09252
Protein Interaction databases
DIP (DOE-UCLA)Q15762
IntAct (EBI)Q15762
BioGRIDCD226
STRING (EMBL)CD226
ZODIACCD226
Ontologies - Pathways
QuickGOQ15762
Ontology : AmiGOcytokine production  positive regulation of natural killer cell cytokine production  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  positive regulation of immunoglobulin mediated immune response  positive regulation of immunoglobulin mediated immune response  integrin binding  protein binding  plasma membrane  integral component of plasma membrane  cell adhesion  signal transduction  cell recognition  external side of plasma membrane  cell surface  protein kinase binding  positive regulation of interferon-gamma production  positive regulation of mast cell activation  positive regulation of mast cell activation  membrane raft  positive regulation of natural killer cell mediated cytotoxicity  regulation of immune response  cell adhesion molecule binding  positive regulation of T cell receptor signaling pathway  positive regulation of T cell receptor signaling pathway  positive regulation of Fc receptor mediated stimulatory signaling pathway  positive regulation of Fc receptor mediated stimulatory signaling pathway  
Ontology : EGO-EBIcytokine production  positive regulation of natural killer cell cytokine production  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  positive regulation of immunoglobulin mediated immune response  positive regulation of immunoglobulin mediated immune response  integrin binding  protein binding  plasma membrane  integral component of plasma membrane  cell adhesion  signal transduction  cell recognition  external side of plasma membrane  cell surface  protein kinase binding  positive regulation of interferon-gamma production  positive regulation of mast cell activation  positive regulation of mast cell activation  membrane raft  positive regulation of natural killer cell mediated cytotoxicity  regulation of immune response  cell adhesion molecule binding  positive regulation of T cell receptor signaling pathway  positive regulation of T cell receptor signaling pathway  positive regulation of Fc receptor mediated stimulatory signaling pathway  positive regulation of Fc receptor mediated stimulatory signaling pathway  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkCD226
Atlas of Cancer Signalling NetworkCD226
Wikipedia pathwaysCD226
Orthology - Evolution
OrthoDB10666
GeneTree (enSembl)ENSG00000150637
Phylogenetic Trees/Animal Genes : TreeFamCD226
Homologs : HomoloGeneCD226
Homology/Alignments : Family Browser (UCSC)CD226
Gene fusions - Rearrangements
Fusion : MitelmanSMAD2/CD226 [18q21.1/18q22.2]  
Fusion : QuiverCD226
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD226 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD226
dbVarCD226
ClinVarCD226
MonarchCD226
1000_GenomesCD226 
Exome Variant ServerCD226
GNOMAD BrowserENSG00000150637
Varsome BrowserCD226
ACMGCD226 variants
VarityQ15762
Genomic Variants (DGV)CD226 [DGVbeta]
DECIPHERCD226 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD226 
Mutations
ICGC Data PortalCD226 
TCGA Data PortalCD226 
Broad Tumor PortalCD226
OASIS PortalCD226 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD226  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCD226
Mutations and Diseases : HGMDCD226
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCD226
DgiDB (Drug Gene Interaction Database)CD226
DoCM (Curated mutations)CD226
CIViC (Clinical Interpretations of Variants in Cancer)CD226
Cancer3DCD226
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605397   
Orphanet
DisGeNETCD226
MedgenCD226
Genetic Testing Registry CD226
NextProtQ15762 [Medical]
GENETestsCD226
Target ValidationCD226
Huge Navigator CD226 [HugePedia]
ClinGenCD226
Clinical trials, drugs, therapy
MyCancerGenomeCD226
Protein Interactions : CTDCD226
Pharm GKB GenePA134911130
PharosQ15762
Clinical trialCD226
Miscellaneous
canSAR (ICR)CD226
HarmonizomeCD226
DataMed IndexCD226
Probes
Litterature
PubMed131 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCD226
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:02:56 CEST 2021

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