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CD226 (CD226 molecule)

Identity

Alias_namesCD226 antigen
Alias_symbol (synonym)DNAM-1
DNAM1
PTA1
TLiSA1
Other alias
HGNC (Hugo) CD226
LocusID (NCBI) 10666
Atlas_Id 46470
Location 18q22.2  [Link to chromosome band 18q22]
Location_base_pair Starts at 67530193 and ends at 67615089 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SMAD2 (18q21.1) / CD226 (18q22.2)SMAD2 18q21.1 / CD226 18q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CD226   16961
Cards
Entrez_Gene (NCBI)CD226  10666  CD226 molecule
AliasesDNAM-1; DNAM1; PTA1; TLiSA1
GeneCards (Weizmann)CD226
Ensembl hg19 (Hinxton)ENSG00000150637 [Gene_View]  chr18:67530193-67615089 [Contig_View]  CD226 [Vega]
Ensembl hg38 (Hinxton)ENSG00000150637 [Gene_View]  chr18:67530193-67615089 [Contig_View]  CD226 [Vega]
ICGC DataPortalENSG00000150637
TCGA cBioPortalCD226
AceView (NCBI)CD226
Genatlas (Paris)CD226
WikiGenes10666
SOURCE (Princeton)CD226
Genetics Home Reference (NIH)CD226
Genomic and cartography
GoldenPath hg19 (UCSC)CD226  -     chr18:67530193-67615089 -  18q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CD226  -     18q22.2   [Description]    (hg38-Dec_2013)
EnsemblCD226 - 18q22.2 [CytoView hg19]  CD226 - 18q22.2 [CytoView hg38]
Mapping of homologs : NCBICD226 [Mapview hg19]  CD226 [Mapview hg38]
OMIM605397   
Gene and transcription
Genbank (Entrez)AJ537553 AK313199 BC074787 DB224741 GU935335
RefSeq transcript (Entrez)NM_001303618 NM_001303619 NM_006566
RefSeq genomic (Entrez)NC_000018 NC_018929 NT_010966 NW_004929411
Consensus coding sequences : CCDS (NCBI)CD226
Cluster EST : UnigeneHs.660130 [ NCBI ]
CGAP (NCI)Hs.660130
Alternative Splicing GalleryENSG00000150637
Gene ExpressionCD226 [ NCBI-GEO ]   CD226 [ EBI - ARRAY_EXPRESS ]   CD226 [ SEEK ]   CD226 [ MEM ]
Gene Expression Viewer (FireBrowse)CD226 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10666
GTEX Portal (Tissue expression)CD226
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15762   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15762  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15762
Splice isoforms : SwissVarQ15762
PhosPhoSitePlusQ15762
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub2    Ig_V-set   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IGc2 (SM00408)  
Conserved Domain (NCBI)CD226
DMDM Disease mutations10666
Blocks (Seattle)CD226
SuperfamilyQ15762
Human Protein AtlasENSG00000150637
Peptide AtlasQ15762
HPRD09252
IPIIPI00008578   
Protein Interaction databases
DIP (DOE-UCLA)Q15762
IntAct (EBI)Q15762
FunCoupENSG00000150637
BioGRIDCD226
STRING (EMBL)CD226
ZODIACCD226
Ontologies - Pathways
QuickGOQ15762
Ontology : AmiGOcytokine production  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  positive regulation of immunoglobulin mediated immune response  receptor activity  integrin binding  protein binding  plasma membrane  integral component of plasma membrane  cell-cell adherens junction  cell adhesion  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  signal transduction  cell recognition  external side of plasma membrane  cell surface  protein kinase binding  positive regulation of mast cell activation  protein homodimerization activity  membrane raft  positive regulation of natural killer cell mediated cytotoxicity  regulation of immune response  cell adhesion molecule binding  positive regulation of Fc receptor mediated stimulatory signaling pathway  
Ontology : EGO-EBIcytokine production  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  positive regulation of immunoglobulin mediated immune response  receptor activity  integrin binding  protein binding  plasma membrane  integral component of plasma membrane  cell-cell adherens junction  cell adhesion  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  signal transduction  cell recognition  external side of plasma membrane  cell surface  protein kinase binding  positive regulation of mast cell activation  protein homodimerization activity  membrane raft  positive regulation of natural killer cell mediated cytotoxicity  regulation of immune response  cell adhesion molecule binding  positive regulation of Fc receptor mediated stimulatory signaling pathway  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkCD226
Atlas of Cancer Signalling NetworkCD226
Wikipedia pathwaysCD226
Orthology - Evolution
OrthoDB10666
GeneTree (enSembl)ENSG00000150637
Phylogenetic Trees/Animal Genes : TreeFamCD226
HOVERGENQ15762
HOGENOMQ15762
Homologs : HomoloGeneCD226
Homology/Alignments : Family Browser (UCSC)CD226
Gene fusions - Rearrangements
Fusion : MitelmanSMAD2/CD226 [18q21.1/18q22.2]  [t(18;18)(q21;q22)]  
Fusion: TCGASMAD2 18q21.1 CD226 18q22.2 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD226 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD226
dbVarCD226
ClinVarCD226
1000_GenomesCD226 
Exome Variant ServerCD226
ExAC (Exome Aggregation Consortium)CD226 (select the gene name)
Genetic variants : HAPMAP10666
Genomic Variants (DGV)CD226 [DGVbeta]
DECIPHER (Syndromes)18:67530193-67615089  ENSG00000150637
CONAN: Copy Number AnalysisCD226 
Mutations
ICGC Data PortalCD226 
TCGA Data PortalCD226 
Broad Tumor PortalCD226
OASIS PortalCD226 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD226  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD226
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD226
DgiDB (Drug Gene Interaction Database)CD226
DoCM (Curated mutations)CD226 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD226 (select a term)
intoGenCD226
Cancer3DCD226(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605397   
Orphanet
MedgenCD226
Genetic Testing Registry CD226
NextProtQ15762 [Medical]
TSGene10666
GENETestsCD226
Huge Navigator CD226 [HugePedia]
snp3D : Map Gene to Disease10666
BioCentury BCIQCD226
ClinGenCD226
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10666
Chemical/Pharm GKB GenePA134911130
Clinical trialCD226
Miscellaneous
canSAR (ICR)CD226 (select the gene name)
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD226
EVEXCD226
GoPubMedCD226
iHOPCD226
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:59:21 CET 2017

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