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CD244 (CD244 molecule)

Identity

Alias_namesnatural killer cell receptor 2B4
CD244 natural killer cell receptor 2B4
CD244 molecule, natural killer cell receptor 2B4
Alias_symbol (synonym)2B4
NAIL
NKR2B4
Nmrk
SLAMF4
Other alias
HGNC (Hugo) CD244
LocusID (NCBI) 51744
Atlas_Id 45803
Location 1q23.3  [Link to chromosome band 1q23]
Location_base_pair Starts at 160799950 and ends at 160832692 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CD244 (1q23.3) / AHCYL2 (7q32.1)CLK2 (1q22) / CD244 (1q23.3)CLK2 1q22 / CD244 1q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CD244   18171
Cards
Entrez_Gene (NCBI)CD244  51744  CD244 molecule
Aliases2B4; NAIL; NKR2B4; Nmrk; 
SLAMF4
GeneCards (Weizmann)CD244
Ensembl hg19 (Hinxton)ENSG00000122223 [Gene_View]  chr1:160799950-160832692 [Contig_View]  CD244 [Vega]
Ensembl hg38 (Hinxton)ENSG00000122223 [Gene_View]  chr1:160799950-160832692 [Contig_View]  CD244 [Vega]
ICGC DataPortalENSG00000122223
TCGA cBioPortalCD244
AceView (NCBI)CD244
Genatlas (Paris)CD244
WikiGenes51744
SOURCE (Princeton)CD244
Genetics Home Reference (NIH)CD244
Genomic and cartography
GoldenPath hg19 (UCSC)CD244  -     chr1:160799950-160832692 -  1q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CD244  -     1q23.3   [Description]    (hg38-Dec_2013)
EnsemblCD244 - 1q23.3 [CytoView hg19]  CD244 - 1q23.3 [CytoView hg38]
Mapping of homologs : NCBICD244 [Mapview hg19]  CD244 [Mapview hg38]
OMIM180300   605554   
Gene and transcription
Genbank (Entrez)AF105261 AF107761 AF117711 AF145782 AF242540
RefSeq transcript (Entrez)NM_001166663 NM_001166664 NM_016382
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_015991 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)CD244
Cluster EST : UnigeneHs.157872 [ NCBI ]
CGAP (NCI)Hs.157872
Alternative Splicing GalleryENSG00000122223
Gene ExpressionCD244 [ NCBI-GEO ]   CD244 [ EBI - ARRAY_EXPRESS ]   CD244 [ SEEK ]   CD244 [ MEM ]
Gene Expression Viewer (FireBrowse)CD244 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51744
GTEX Portal (Tissue expression)CD244
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZW8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZW8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZW8
Splice isoforms : SwissVarQ9BZW8
PhosPhoSitePlusQ9BZW8
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    NK_rcpt_2B4    NK_rcpt_2B4_Ig_dom   
Domain families : Pfam (Sanger)Receptor_2B4 (PF11465)   
Domain families : Pfam (NCBI)pfam11465   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)CD244
DMDM Disease mutations51744
Blocks (Seattle)CD244
SuperfamilyQ9BZW8
Human Protein AtlasENSG00000122223
Peptide AtlasQ9BZW8
HPRD16121
IPIIPI00411526   IPI00184175   IPI00411528   IPI00015548   
Protein Interaction databases
DIP (DOE-UCLA)Q9BZW8
IntAct (EBI)Q9BZW8
FunCoupENSG00000122223
BioGRIDCD244
STRING (EMBL)CD244
ZODIACCD244
Ontologies - Pathways
QuickGOQ9BZW8
Ontology : AmiGOmyeloid dendritic cell activation  adaptive immune response  natural killer cell activation involved in immune response  receptor activity  protein binding  plasma membrane  signal transduction  external side of plasma membrane  integral component of membrane  positive regulation of natural killer cell proliferation  MHC class I protein binding  innate immune response  leukocyte migration  positive regulation of inositol phosphate biosynthetic process  positive regulation of granzyme B production  positive regulation of interferon-gamma secretion  positive regulation of interleukin-8 secretion  positive regulation of CD8-positive, alpha-beta T cell proliferation  
Ontology : EGO-EBImyeloid dendritic cell activation  adaptive immune response  natural killer cell activation involved in immune response  receptor activity  protein binding  plasma membrane  signal transduction  external side of plasma membrane  integral component of membrane  positive regulation of natural killer cell proliferation  MHC class I protein binding  innate immune response  leukocyte migration  positive regulation of inositol phosphate biosynthetic process  positive regulation of granzyme B production  positive regulation of interferon-gamma secretion  positive regulation of interleukin-8 secretion  positive regulation of CD8-positive, alpha-beta T cell proliferation  
Pathways : KEGGNatural killer cell mediated cytotoxicity   
NDEx NetworkCD244
Atlas of Cancer Signalling NetworkCD244
Wikipedia pathwaysCD244
Orthology - Evolution
OrthoDB51744
GeneTree (enSembl)ENSG00000122223
Phylogenetic Trees/Animal Genes : TreeFamCD244
HOVERGENQ9BZW8
HOGENOMQ9BZW8
Homologs : HomoloGeneCD244
Homology/Alignments : Family Browser (UCSC)CD244
Gene fusions - Rearrangements
Fusion : MitelmanCLK2/CD244 [1q22/1q23.3]  [t(1;1)(q22;q23)]  
Fusion: TCGACLK2 1q22 CD244 1q23.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD244 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD244
dbVarCD244
ClinVarCD244
1000_GenomesCD244 
Exome Variant ServerCD244
ExAC (Exome Aggregation Consortium)CD244 (select the gene name)
Genetic variants : HAPMAP51744
Genomic Variants (DGV)CD244 [DGVbeta]
DECIPHER (Syndromes)1:160799950-160832692  ENSG00000122223
CONAN: Copy Number AnalysisCD244 
Mutations
ICGC Data PortalCD244 
TCGA Data PortalCD244 
Broad Tumor PortalCD244
OASIS PortalCD244 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD244  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD244
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD244
DgiDB (Drug Gene Interaction Database)CD244
DoCM (Curated mutations)CD244 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD244 (select a term)
intoGenCD244
Cancer3DCD244(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180300    605554   
Orphanet
MedgenCD244
Genetic Testing Registry CD244
NextProtQ9BZW8 [Medical]
TSGene51744
GENETestsCD244
Huge Navigator CD244 [HugePedia]
snp3D : Map Gene to Disease51744
BioCentury BCIQCD244
ClinGenCD244
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51744
Chemical/Pharm GKB GenePA134905192
Clinical trialCD244
Miscellaneous
canSAR (ICR)CD244 (select the gene name)
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD244
EVEXCD244
GoPubMedCD244
iHOPCD244
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:55:37 CEST 2017

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