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CD27 (CD27 molecule)

Identity

Alias_namesTNFRSF7
tumor necrosis factor receptor superfamily
Alias_symbol (synonym)S152
Tp55
Other aliasS152. LPFS2
T14
HGNC (Hugo) CD27
LocusID (NCBI) 939
Atlas_Id 42629
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 6444885 and ends at 6451718 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CD27 (12p13.31) / SON (21q22.11)FAM60A (12p11.21) / CD27 (12p13.31)FAM60A 12p11.21 / CD27 12p13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CD27   11922
LRG (Locus Reference Genomic)LRG_357
Cards
Entrez_Gene (NCBI)CD27  939  CD27 molecule
AliasesS152; S152.; T14; TNFRSF7; 
Tp55
GeneCards (Weizmann)CD27
Ensembl hg19 (Hinxton)ENSG00000139193 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139193 [Gene_View]  chr12:6444885-6451718 [Contig_View]  CD27 [Vega]
ICGC DataPortalENSG00000139193
TCGA cBioPortalCD27
AceView (NCBI)CD27
Genatlas (Paris)CD27
WikiGenes939
SOURCE (Princeton)CD27
Genetics Home Reference (NIH)CD27
Genomic and cartography
GoldenPath hg38 (UCSC)CD27  -     chr12:6444885-6451718 +  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD27  -     12p13.31   [Description]    (hg19-Feb_2009)
EnsemblCD27 - 12p13.31 [CytoView hg19]  CD27 - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBICD27 [Mapview hg19]  CD27 [Mapview hg38]
OMIM186711   615122   
Gene and transcription
Genbank (Entrez)AK315732 BC012160 BI225100 DQ892296 EU176659
RefSeq transcript (Entrez)NM_001242
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD27
Cluster EST : UnigeneHs.355307 [ NCBI ]
CGAP (NCI)Hs.355307
Alternative Splicing GalleryENSG00000139193
Gene ExpressionCD27 [ NCBI-GEO ]   CD27 [ EBI - ARRAY_EXPRESS ]   CD27 [ SEEK ]   CD27 [ MEM ]
Gene Expression Viewer (FireBrowse)CD27 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)939
GTEX Portal (Tissue expression)CD27
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26842   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26842  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26842
Splice isoforms : SwissVarP26842
PhosPhoSitePlusP26842
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_7    TNFRSF7_N   
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
Conserved Domain (NCBI)CD27
DMDM Disease mutations939
Blocks (Seattle)CD27
SuperfamilyP26842
Human Protein AtlasENSG00000139193
Peptide AtlasP26842
HPRD01723
IPIIPI00002435   
Protein Interaction databases
DIP (DOE-UCLA)P26842
IntAct (EBI)P26842
FunCoupENSG00000139193
BioGRIDCD27
STRING (EMBL)CD27
ZODIACCD27
Ontologies - Pathways
QuickGOP26842
Ontology : AmiGOtransmembrane signaling receptor activity  tumor necrosis factor-activated receptor activity  protein binding  extracellular region  intracellular  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  inflammatory response  immune response  cell surface receptor signaling pathway  multicellular organism development  release of cytoplasmic sequestered NF-kappaB  external side of plasma membrane  immunoglobulin mediated immune response  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  regulation of cell proliferation  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  response to ethanol  positive regulation of B cell differentiation  positive regulation of T cell differentiation  positive regulation of JNK cascade  extracellular exosome  negative regulation of T cell apoptotic process  extrinsic apoptotic signaling pathway  
Ontology : EGO-EBItransmembrane signaling receptor activity  tumor necrosis factor-activated receptor activity  protein binding  extracellular region  intracellular  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  inflammatory response  immune response  cell surface receptor signaling pathway  multicellular organism development  release of cytoplasmic sequestered NF-kappaB  external side of plasma membrane  immunoglobulin mediated immune response  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  regulation of cell proliferation  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  response to ethanol  positive regulation of B cell differentiation  positive regulation of T cell differentiation  positive regulation of JNK cascade  extracellular exosome  negative regulation of T cell apoptotic process  extrinsic apoptotic signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkCD27
Atlas of Cancer Signalling NetworkCD27
Wikipedia pathwaysCD27
Orthology - Evolution
OrthoDB939
GeneTree (enSembl)ENSG00000139193
Phylogenetic Trees/Animal Genes : TreeFamCD27
HOVERGENP26842
HOGENOMP26842
Homologs : HomoloGeneCD27
Homology/Alignments : Family Browser (UCSC)CD27
Gene fusions - Rearrangements
Fusion : MitelmanFAM60A/CD27 [12p11.21/12p13.31]  [t(12;12)(p11;p13)]  
Fusion: TCGAFAM60A 12p11.21 CD27 12p13.31 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD27 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD27
dbVarCD27
ClinVarCD27
1000_GenomesCD27 
Exome Variant ServerCD27
ExAC (Exome Aggregation Consortium)CD27 (select the gene name)
Genetic variants : HAPMAP939
Genomic Variants (DGV)CD27 [DGVbeta]
DECIPHERCD27 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD27 
Mutations
ICGC Data PortalCD27 
TCGA Data PortalCD27 
Broad Tumor PortalCD27
OASIS PortalCD27 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD27  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD27
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch CD27
DgiDB (Drug Gene Interaction Database)CD27
DoCM (Curated mutations)CD27 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD27 (select a term)
intoGenCD27
Cancer3DCD27(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186711    615122   
Orphanet19269   
MedgenCD27
Genetic Testing Registry CD27
NextProtP26842 [Medical]
TSGene939
GENETestsCD27
Target ValidationCD27
Huge Navigator CD27 [HugePedia]
snp3D : Map Gene to Disease939
BioCentury BCIQCD27
ClinGenCD27
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD939
Chemical/Pharm GKB GenePA162382107
Clinical trialCD27
Miscellaneous
canSAR (ICR)CD27 (select the gene name)
Probes
Litterature
PubMed103 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD27
EVEXCD27
GoPubMedCD27
iHOPCD27
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:27:23 CEST 2017

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