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CD274 (CD274 molecule)

Identity

Alias_namesPDCD1LG1
programmed cell death 1 ligand 1
CD274 antigen
Alias_symbol (synonym)B7-H
B7H1
PD-L1
PDL1
B7-H1
Other aliasPDCD1L1
HGNC (Hugo) CD274
LocusID (NCBI) 29126
Atlas_Id 46492
Location 9p24.1  [Link to chromosome band 9p24]
Location_base_pair Starts at 5450503 and ends at 5470567 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CD274 (9p24.1) / CIITA (16p13.13)CD274 (9p24.1) / DMRT1 (9p24.3)CIITA (16p13.13) / CD274 (9p24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  del(9p) in Acute Lymphoblastic Leukemia
Follicular Dendritic Cell Sarcoma
Primary mediastinal B-cell lymphoma (PMBL)


External links

Nomenclature
HGNC (Hugo)CD274   17635
Cards
Entrez_Gene (NCBI)CD274  29126  CD274 molecule
AliasesB7-H; B7H1; PD-L1; PDCD1L1; 
PDCD1LG1; PDL1
GeneCards (Weizmann)CD274
Ensembl hg19 (Hinxton)ENSG00000120217 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120217 [Gene_View]  chr9:5450503-5470567 [Contig_View]  CD274 [Vega]
ICGC DataPortalENSG00000120217
TCGA cBioPortalCD274
AceView (NCBI)CD274
Genatlas (Paris)CD274
WikiGenes29126
SOURCE (Princeton)CD274
Genetics Home Reference (NIH)CD274
Genomic and cartography
GoldenPath hg38 (UCSC)CD274  -     chr9:5450503-5470567 +  9p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD274  -     9p24.1   [Description]    (hg19-Feb_2009)
EnsemblCD274 - 9p24.1 [CytoView hg19]  CD274 - 9p24.1 [CytoView hg38]
Mapping of homologs : NCBICD274 [Mapview hg19]  CD274 [Mapview hg38]
OMIM605402   
Gene and transcription
Genbank (Entrez)AA399416 AF177937 AF233516 AI826502 AK001894
RefSeq transcript (Entrez)NM_001267706 NM_001314029 NM_014143
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD274
Cluster EST : UnigeneHs.521989 [ NCBI ]
CGAP (NCI)Hs.521989
Alternative Splicing GalleryENSG00000120217
Gene ExpressionCD274 [ NCBI-GEO ]   CD274 [ EBI - ARRAY_EXPRESS ]   CD274 [ SEEK ]   CD274 [ MEM ]
Gene Expression Viewer (FireBrowse)CD274 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29126
GTEX Portal (Tissue expression)CD274
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZQ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZQ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZQ7
Splice isoforms : SwissVarQ9NZQ7
PhosPhoSitePlusQ9NZQ7
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    Ig-like_dom    Ig-like_fold    Ig_sub    Ig_V-set   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam08205    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)CD274
DMDM Disease mutations29126
Blocks (Seattle)CD274
PDB (SRS)3BIK    3BIS    3FN3    3SBW    4Z18    4ZQK    5C3T    5GGT    5GRJ    5IUS    5J89    5J8O   
PDB (PDBSum)3BIK    3BIS    3FN3    3SBW    4Z18    4ZQK    5C3T    5GGT    5GRJ    5IUS    5J89    5J8O   
PDB (IMB)3BIK    3BIS    3FN3    3SBW    4Z18    4ZQK    5C3T    5GGT    5GRJ    5IUS    5J89    5J8O   
PDB (RSDB)3BIK    3BIS    3FN3    3SBW    4Z18    4ZQK    5C3T    5GGT    5GRJ    5IUS    5J89    5J8O   
Structural Biology KnowledgeBase3BIK    3BIS    3FN3    3SBW    4Z18    4ZQK    5C3T    5GGT    5GRJ    5IUS    5J89    5J8O   
SCOP (Structural Classification of Proteins)3BIK    3BIS    3FN3    3SBW    4Z18    4ZQK    5C3T    5GGT    5GRJ    5IUS    5J89    5J8O   
CATH (Classification of proteins structures)3BIK    3BIS    3FN3    3SBW    4Z18    4ZQK    5C3T    5GGT    5GRJ    5IUS    5J89    5J8O   
SuperfamilyQ9NZQ7
Human Protein AtlasENSG00000120217
Peptide AtlasQ9NZQ7
HPRD05655
IPIIPI00023021   IPI00446867   IPI00556058   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZQ7
IntAct (EBI)Q9NZQ7
FunCoupENSG00000120217
BioGRIDCD274
STRING (EMBL)CD274
ZODIACCD274
Ontologies - Pathways
QuickGOQ9NZQ7
Ontology : AmiGOprotein binding  plasma membrane  immune response  signal transduction  cell surface receptor signaling pathway  external side of plasma membrane  endomembrane system  integral component of membrane  positive regulation of cell migration  T cell costimulation  T cell costimulation  negative regulation of interferon-gamma production  negative regulation of interleukin-10 production  response to cytokine  positive regulation of T cell proliferation  regulation of activated T cell proliferation  negative regulation of activated T cell proliferation  extracellular exosome  regulation of T cell apoptotic process  toxin transport  negative regulation of tumor necrosis factor superfamily cytokine production  regulation of activated CD4-positive, alpha-beta T cell apoptotic process  positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process  positive regulation of interleukin-10 secretion  
Ontology : EGO-EBIprotein binding  plasma membrane  immune response  signal transduction  cell surface receptor signaling pathway  external side of plasma membrane  endomembrane system  integral component of membrane  positive regulation of cell migration  T cell costimulation  T cell costimulation  negative regulation of interferon-gamma production  negative regulation of interleukin-10 production  response to cytokine  positive regulation of T cell proliferation  regulation of activated T cell proliferation  negative regulation of activated T cell proliferation  extracellular exosome  regulation of T cell apoptotic process  toxin transport  negative regulation of tumor necrosis factor superfamily cytokine production  regulation of activated CD4-positive, alpha-beta T cell apoptotic process  positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process  positive regulation of interleukin-10 secretion  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkCD274
Atlas of Cancer Signalling NetworkCD274
Wikipedia pathwaysCD274
Orthology - Evolution
OrthoDB29126
GeneTree (enSembl)ENSG00000120217
Phylogenetic Trees/Animal Genes : TreeFamCD274
HOVERGENQ9NZQ7
HOGENOMQ9NZQ7
Homologs : HomoloGeneCD274
Homology/Alignments : Family Browser (UCSC)CD274
Gene fusions - Rearrangements
Fusion : MitelmanCIITA/CD274 [16p13.13/9p24.1]  [t(9;16)(p24;p13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD274 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD274
dbVarCD274
ClinVarCD274
1000_GenomesCD274 
Exome Variant ServerCD274
ExAC (Exome Aggregation Consortium)CD274 (select the gene name)
Genetic variants : HAPMAP29126
Genomic Variants (DGV)CD274 [DGVbeta]
DECIPHERCD274 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD274 
Mutations
ICGC Data PortalCD274 
TCGA Data PortalCD274 
Broad Tumor PortalCD274
OASIS PortalCD274 [ Somatic mutations - Copy number]
Cancer Gene: CensusCD274 
Somatic Mutations in Cancer : COSMICCD274  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD274
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD274
DgiDB (Drug Gene Interaction Database)CD274
DoCM (Curated mutations)CD274 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD274 (select a term)
intoGenCD274
Cancer3DCD274(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605402   
Orphanet
MedgenCD274
Genetic Testing Registry CD274
NextProtQ9NZQ7 [Medical]
TSGene29126
GENETestsCD274
Huge Navigator CD274 [HugePedia]
snp3D : Map Gene to Disease29126
BioCentury BCIQCD274
ClinGenCD274
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29126
Chemical/Pharm GKB GenePA134915280
Clinical trialCD274
Miscellaneous
canSAR (ICR)CD274 (select the gene name)
Probes
Litterature
PubMed471 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD274
EVEXCD274
GoPubMedCD274
iHOPCD274
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:09:35 CEST 2017

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