CD274 (CD274 molecule)

2007-02-01  

Identity

HGNC
LOCATION
9p24.1
LOCUSID
ALIAS
B7-H,B7H1,PD-L1,PDCD1L1,PDCD1LG1,PDL1,hPD-L1
FUSION GENES

Other Information

Locus ID:

NCBI: 29126
MIM: 605402
HGNC: 17635
Ensembl: ENSG00000120217

Variants:

dbSNP: 29126
ClinVar: 29126
TCGA: ENSG00000120217
COSMIC: CD274

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120217ENST00000381573Q9NZQ7
ENSG00000120217ENST00000381577Q9NZQ7

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Costimulation by the CD28 familyREACTOMER-HSA-388841
PD-1 signalingREACTOMER-HSA-389948

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166124615pembrolizumabChemicalLabelAnnotation, MultilinkAnnotationassociated26086854
PA166129522nivolumabChemicalLabelAnnotation, MultilinkAnnotationassociated26086854
PA166129523atezolizumabChemicalLabelAnnotationassociated
PA166157522rs113488022VariantLabelAnnotationassociated
PA166169875avelumabChemicalLabelAnnotationassociated
PA166169883durvalumabChemicalLabelAnnotationassociated

References

Pubmed IDYearTitleCitations
181733752008PD-1 and its ligands in tolerance and immunity.1482
120918762002Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.1418
224616412012Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.763
247147712014Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy.698
206368202010The PD-1 pathway in tolerance and autoimmunity.604
239864002013Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.495
173606512007Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.487
288353862017Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers.341
206281452010Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.326
259773402015Classifying Cancers Based on T-cell Infiltration and PD-L1.323

Citation

Dessen P

CD274 (CD274 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46492/cd274