CD276 (CD276 molecule)

2007-02-01 Affiliation

Identity

HGNC

CD276

LOCATION

15q24.1

LOCUSID

80381

ALIAS

4Ig-B7-H3,B7-H3,B7H3,B7RP-2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 80381
MIM: 605715
HGNC: 19137
Ensembl: ENSG00000103855

Variants:

dbSNP: 80381
ClinVar: 80381
TCGA: ENSG00000103855
COSMIC: CD276

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000103855	ENST00000318424	Q5ZPR3
ENSG00000103855	ENST00000318443	Q5ZPR3
ENSG00000103855	ENST00000537340	A0A0C4DGH0
ENSG00000103855	ENST00000558689	H0YN85
ENSG00000103855	ENST00000559073	H0YN29
ENSG00000103855	ENST00000560786	H0YK40
ENSG00000103855	ENST00000560928	H0YLT3
ENSG00000103855	ENST00000560995	H0YLT8
ENSG00000103855	ENST00000561176	H0YL10
ENSG00000103855	ENST00000561213	Q5ZPR3
ENSG00000103855	ENST00000561260	H0YK59
ENSG00000103855	ENST00000561416	H0YKQ9
ENSG00000103855	ENST00000563584	H3BM68
ENSG00000103855	ENST00000564751	Q5ZPR3
ENSG00000103855	ENST00000567189	H0YLT8
ENSG00000103855	ENST00000567582	H0YLT3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Cell adhesion molecules (CAMs)	KEGG	hsa04514

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18694993	2008	Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma.	96
12055244	2002	Characterization of mouse and human B7-H3 genes.	83
19544488	2009	B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction.	80
15314238	2004	Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis.	77
18676751	2008	T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival.	76
18650384	2008	Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses.	64
28399408	2017	Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.	52
20333377	2010	Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma.	51
20035626	2009	Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer.	44
21107115	2010	B7-h3 ligand expression by primary breast cancer and associated with regional nodal metastasis.	43

Citation

Dessen P

CD276 (CD276 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43652/cd276