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CD28 (CD28 molecule)

Identity

Alias_namesCD28 antigen (Tp44)
Other aliasTp44
HGNC (Hugo) CD28
LocusID (NCBI) 940
Atlas_Id 52848
Location 2q33.2  [Link to chromosome band 2q33]
Location_base_pair Starts at 203706475 and ends at 203738912 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CD28 (2q33.2) / KANSL2 (12q13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CD28   1653
Cards
Entrez_Gene (NCBI)CD28  940  CD28 molecule
AliasesTp44
GeneCards (Weizmann)CD28
Ensembl hg19 (Hinxton)ENSG00000178562 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178562 [Gene_View]  chr2:203706475-203738912 [Contig_View]  CD28 [Vega]
ICGC DataPortalENSG00000178562
TCGA cBioPortalCD28
AceView (NCBI)CD28
Genatlas (Paris)CD28
WikiGenes940
SOURCE (Princeton)CD28
Genetics Home Reference (NIH)CD28
Genomic and cartography
GoldenPath hg38 (UCSC)CD28  -     chr2:203706475-203738912 +  2q33.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD28  -     2q33.2   [Description]    (hg19-Feb_2009)
EnsemblCD28 - 2q33.2 [CytoView hg19]  CD28 - 2q33.2 [CytoView hg38]
Mapping of homologs : NCBICD28 [Mapview hg19]  CD28 [Mapview hg38]
OMIM186760   
Gene and transcription
Genbank (Entrez)AA311148 AF222341 AF222342 AF222343 AJ295273
RefSeq transcript (Entrez)NM_001243077 NM_001243078 NM_006139
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD28
Cluster EST : UnigeneHs.443123 [ NCBI ]
CGAP (NCI)Hs.443123
Alternative Splicing GalleryENSG00000178562
Gene ExpressionCD28 [ NCBI-GEO ]   CD28 [ EBI - ARRAY_EXPRESS ]   CD28 [ SEEK ]   CD28 [ MEM ]
Gene Expression Viewer (FireBrowse)CD28 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)940
GTEX Portal (Tissue expression)CD28
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10747   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10747  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10747
Splice isoforms : SwissVarP10747
PhosPhoSitePlusP10747
Domains : Interpro (EBI)CD28    Ig-like_dom    Ig-like_fold    Ig_V-set   
Domain families : Pfam (Sanger)V-set_2 (PF15910)   
Domain families : Pfam (NCBI)pfam15910   
Domain families : Smart (EMBL)IGv (SM00406)  
Conserved Domain (NCBI)CD28
DMDM Disease mutations940
Blocks (Seattle)CD28
PDB (SRS)1YJD    3WA4    5AUL    5GJH    5GJI   
PDB (PDBSum)1YJD    3WA4    5AUL    5GJH    5GJI   
PDB (IMB)1YJD    3WA4    5AUL    5GJH    5GJI   
PDB (RSDB)1YJD    3WA4    5AUL    5GJH    5GJI   
Structural Biology KnowledgeBase1YJD    3WA4    5AUL    5GJH    5GJI   
SCOP (Structural Classification of Proteins)1YJD    3WA4    5AUL    5GJH    5GJI   
CATH (Classification of proteins structures)1YJD    3WA4    5AUL    5GJH    5GJI   
SuperfamilyP10747
Human Protein AtlasENSG00000178562
Peptide AtlasP10747
HPRD01727
IPIIPI00022339   IPI00215639   IPI00215640   IPI00215641   IPI00215643   IPI00215645   IPI00876940   IPI00428846   
Protein Interaction databases
DIP (DOE-UCLA)P10747
IntAct (EBI)P10747
FunCoupENSG00000178562
BioGRIDCD28
STRING (EMBL)CD28
ZODIACCD28
Ontologies - Pathways
QuickGOP10747
Ontology : AmiGOimmunological synapse  protease binding  positive regulation of inflammatory response to antigenic stimulus  SH3/SH2 adaptor activity  protein binding  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  humoral immune response  cell surface receptor signaling pathway  external side of plasma membrane  cell surface  positive regulation of gene expression  negative regulation of gene expression  regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  coreceptor activity  protein kinase binding  T cell costimulation  positive regulation of interleukin-10 production  positive regulation of interleukin-4 production  cytokine biosynthetic process  positive regulation of T cell proliferation  positive regulation of T cell proliferation  positive regulation of T cell proliferation  identical protein binding  negative thymic T cell selection  regulatory T cell differentiation  positive regulation of viral genome replication  positive regulation of interleukin-2 biosynthetic process  positive regulation of interleukin-2 biosynthetic process  regulation of regulatory T cell differentiation  positive regulation of translation  positive regulation of mitotic nuclear division  positive regulation of mitotic nuclear division  positive regulation of transcription from RNA polymerase II promoter  positive regulation of alpha-beta T cell proliferation  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of isotype switching to IgG isotypes  regulation of defense response to virus by virus  T cell receptor signaling pathway  positive regulation of protein kinase B signaling  apoptotic signaling pathway  protein complex involved in cell adhesion  
Ontology : EGO-EBIimmunological synapse  protease binding  positive regulation of inflammatory response to antigenic stimulus  SH3/SH2 adaptor activity  protein binding  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  humoral immune response  cell surface receptor signaling pathway  external side of plasma membrane  cell surface  positive regulation of gene expression  negative regulation of gene expression  regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  coreceptor activity  protein kinase binding  T cell costimulation  positive regulation of interleukin-10 production  positive regulation of interleukin-4 production  cytokine biosynthetic process  positive regulation of T cell proliferation  positive regulation of T cell proliferation  positive regulation of T cell proliferation  identical protein binding  negative thymic T cell selection  regulatory T cell differentiation  positive regulation of viral genome replication  positive regulation of interleukin-2 biosynthetic process  positive regulation of interleukin-2 biosynthetic process  regulation of regulatory T cell differentiation  positive regulation of translation  positive regulation of mitotic nuclear division  positive regulation of mitotic nuclear division  positive regulation of transcription from RNA polymerase II promoter  positive regulation of alpha-beta T cell proliferation  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of isotype switching to IgG isotypes  regulation of defense response to virus by virus  T cell receptor signaling pathway  positive regulation of protein kinase B signaling  apoptotic signaling pathway  protein complex involved in cell adhesion  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkCD28
Atlas of Cancer Signalling NetworkCD28
Wikipedia pathwaysCD28
Orthology - Evolution
OrthoDB940
GeneTree (enSembl)ENSG00000178562
Phylogenetic Trees/Animal Genes : TreeFamCD28
HOVERGENP10747
HOGENOMP10747
Homologs : HomoloGeneCD28
Homology/Alignments : Family Browser (UCSC)CD28
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD28 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD28
dbVarCD28
ClinVarCD28
1000_GenomesCD28 
Exome Variant ServerCD28
ExAC (Exome Aggregation Consortium)CD28 (select the gene name)
Genetic variants : HAPMAP940
Genomic Variants (DGV)CD28 [DGVbeta]
DECIPHERCD28 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD28 
Mutations
ICGC Data PortalCD28 
TCGA Data PortalCD28 
Broad Tumor PortalCD28
OASIS PortalCD28 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD28  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD28
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD28
DgiDB (Drug Gene Interaction Database)CD28
DoCM (Curated mutations)CD28 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD28 (select a term)
intoGenCD28
Cancer3DCD28(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186760   
Orphanet3400    3401   
MedgenCD28
Genetic Testing Registry CD28
NextProtP10747 [Medical]
TSGene940
GENETestsCD28
Target ValidationCD28
Huge Navigator CD28 [HugePedia]
snp3D : Map Gene to Disease940
BioCentury BCIQCD28
ClinGenCD28
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD940
Chemical/Pharm GKB GenePA26207
Clinical trialCD28
Miscellaneous
canSAR (ICR)CD28 (select the gene name)
Probes
Litterature
PubMed337 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD28
EVEXCD28
GoPubMedCD28
iHOPCD28
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:27:24 CEST 2017

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