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CD33 (CD33 molecule)

Identity

Alias (NCBI)SIGLEC-3
SIGLEC3
p67
HGNC (Hugo) CD33
HGNC Alias symbSIGLEC3
SIGLEC-3
p67
FLJ00391
HGNC Alias namesialic acid binding Ig-like lectin 3
HGNC Previous nameCD33 antigen (gp67)
LocusID (NCBI) 945
Atlas_Id 974
Location 19q13.41  [Link to chromosome band 19q13]
Location_base_pair Starts at 51225080 and ends at 51240016 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD33 (19q13.41) / LOC100507412 (-)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CD33   1659
Cards
Entrez_Gene (NCBI)CD33    CD33 molecule
AliasesSIGLEC-3; SIGLEC3; p67
GeneCards (Weizmann)CD33
Ensembl hg19 (Hinxton)ENSG00000105383 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105383 [Gene_View]  ENSG00000105383 [Sequence]  chr19:51225080-51240016 [Contig_View]  CD33 [Vega]
ICGC DataPortalENSG00000105383
TCGA cBioPortalCD33
AceView (NCBI)CD33
Genatlas (Paris)CD33
SOURCE (Princeton)CD33
Genetics Home Reference (NIH)CD33
Genomic and cartography
GoldenPath hg38 (UCSC)CD33  -     chr19:51225080-51240016 +  19q13.41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD33  -     19q13.41   [Description]    (hg19-Feb_2009)
GoldenPathCD33 - 19q13.41 [CytoView hg19]  CD33 - 19q13.41 [CytoView hg38]
ImmunoBaseENSG00000105383
Genome Data Viewer NCBICD33 [Mapview hg19]  
OMIM159590   
Gene and transcription
Genbank (Entrez)AK090470 AK293934 AK304810 AK309558 AW007749
RefSeq transcript (Entrez)NM_001082618 NM_001177608 NM_001772
Consensus coding sequences : CCDS (NCBI)CD33
Gene ExpressionCD33 [ NCBI-GEO ]   CD33 [ EBI - ARRAY_EXPRESS ]   CD33 [ SEEK ]   CD33 [ MEM ]
Gene Expression Viewer (FireBrowse)CD33 [ Firebrowse - Broad ]
GenevisibleExpression of CD33 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)945
GTEX Portal (Tissue expression)CD33
Human Protein AtlasENSG00000105383-CD33 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20138   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20138  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20138
PhosPhoSitePlusP20138
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set    Immunoglobulin   
Domain families : Pfam (Sanger)ig (PF00047)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam00047    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)CD33
PDB (RSDB)5IHB    5J06    5J0B    6D48    6D49    6D4A    6TL8   
PDB Europe5IHB    5J06    5J0B    6D48    6D49    6D4A    6TL8   
PDB (PDBSum)5IHB    5J06    5J0B    6D48    6D49    6D4A    6TL8   
PDB (IMB)5IHB    5J06    5J0B    6D48    6D49    6D4A    6TL8   
Structural Biology KnowledgeBase5IHB    5J06    5J0B    6D48    6D49    6D4A    6TL8   
SCOP (Structural Classification of Proteins)5IHB    5J06    5J0B    6D48    6D49    6D4A    6TL8   
CATH (Classification of proteins structures)5IHB    5J06    5J0B    6D48    6D49    6D4A    6TL8   
SuperfamilyP20138
AlphaFold pdb e-kbP20138   
Human Protein Atlas [tissue]ENSG00000105383-CD33 [tissue]
HPRD01165
Protein Interaction databases
DIP (DOE-UCLA)P20138
IntAct (EBI)P20138
BioGRIDCD33
STRING (EMBL)CD33
ZODIACCD33
Ontologies - Pathways
QuickGOP20138
Ontology : AmiGOimmune response-inhibiting signal transduction  protein binding  nucleoplasm  peroxisome  Golgi apparatus  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  cell adhesion  signal transduction  cell-cell signaling  negative regulation of cell population proliferation  external side of plasma membrane  protein phosphatase binding  carbohydrate binding  negative regulation of interleukin-1 beta production  negative regulation of interleukin-8 production  negative regulation of tumor necrosis factor production  sialic acid binding  sialic acid binding  specific granule membrane  signaling receptor activity  neutrophil degranulation  positive regulation of protein secretion  regulation of immune response  negative regulation of calcium ion transport  tertiary granule membrane  cell-cell adhesion  negative regulation of monocyte activation  positive regulation of protein tyrosine phosphatase activity  
Ontology : EGO-EBIimmune response-inhibiting signal transduction  protein binding  nucleoplasm  peroxisome  Golgi apparatus  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  cell adhesion  signal transduction  cell-cell signaling  negative regulation of cell population proliferation  external side of plasma membrane  protein phosphatase binding  carbohydrate binding  negative regulation of interleukin-1 beta production  negative regulation of interleukin-8 production  negative regulation of tumor necrosis factor production  sialic acid binding  sialic acid binding  specific granule membrane  signaling receptor activity  neutrophil degranulation  positive regulation of protein secretion  regulation of immune response  negative regulation of calcium ion transport  tertiary granule membrane  cell-cell adhesion  negative regulation of monocyte activation  positive regulation of protein tyrosine phosphatase activity  
Pathways : BIOCARTADendritic cells in regulating TH1 and TH2 Development [Genes]   
Pathways : KEGGHematopoietic cell lineage   
NDEx NetworkCD33
Atlas of Cancer Signalling NetworkCD33
Wikipedia pathwaysCD33
Orthology - Evolution
OrthoDB945
GeneTree (enSembl)ENSG00000105383
Phylogenetic Trees/Animal Genes : TreeFamCD33
Homologs : HomoloGeneCD33
Homology/Alignments : Family Browser (UCSC)CD33
Gene fusions - Rearrangements
Fusion : QuiverCD33
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD33 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD33
dbVarCD33
ClinVarCD33
MonarchCD33
1000_GenomesCD33 
Exome Variant ServerCD33
GNOMAD BrowserENSG00000105383
Varsome BrowserCD33
ACMGCD33 variants
VarityP20138
Genomic Variants (DGV)CD33 [DGVbeta]
DECIPHERCD33 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD33 
Mutations
ICGC Data PortalCD33 
TCGA Data PortalCD33 
Broad Tumor PortalCD33
OASIS PortalCD33 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD33  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCD33
Mutations and Diseases : HGMDCD33
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCD33
DgiDB (Drug Gene Interaction Database)CD33
DoCM (Curated mutations)CD33
CIViC (Clinical Interpretations of Variants in Cancer)CD33
Cancer3DCD33
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM159590   
Orphanet
DisGeNETCD33
MedgenCD33
Genetic Testing Registry CD33
NextProtP20138 [Medical]
GENETestsCD33
Target ValidationCD33
Huge Navigator CD33 [HugePedia]
ClinGenCD33
Clinical trials, drugs, therapy
MyCancerGenomeCD33
Protein Interactions : CTDCD33
Pharm GKB GenePA26210
Pharm GKB PathwaysPA166115250   
PharosP20138
Clinical trialCD33
Miscellaneous
canSAR (ICR)CD33
HarmonizomeCD33
DataMed IndexCD33
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCD33
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:02:58 CEST 2021

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