Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CD34 (CD34 molecule)

Identity

Alias (NCBI)-
HGNC (Hugo) CD34
HGNC Previous nameCD34 antigen
LocusID (NCBI) 947
Atlas_Id 975
Location 1q32.2  [Link to chromosome band 1q32]
Location_base_pair Starts at 207886538 and ends at 207911125 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD34 (1q32.2) / CD34 (1q32.2)CD34 (1q32.2) / DBN1 (5q35.3)CD34 (1q32.2) / DEPDC1B (5q12.1)
CD34 (1q32.2) / GIMAP4 (7q36.1)CD55 (1q32.2) / CD34 (1q32.2)HHAT (1q32.2) / CD34 (1q32.2)
LOC100507412 (-) / CD34 (1q32.2)RPS6KC1 (1q32.3) / CD34 (1q32.2)HHAT 1q32.2 / CD34 1q32.2
RPS6KC1 1q32.3 / CD34 1q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 9 ]
  Soft Tissues: Deep (aggressive) angiomyxoma
Heart: Cardiac Myxoma
Soft Tissues: Dermatofibrosarcoma Protuberans with t/r(17;22)(q21;q13) PDGFB/COL1A1
Soft Tissues: Desmoid-type fibromatosis
Bone: Epithelioid hemangioendothelioma with t(1;3)(p36;q25) WWRT1/CAMTA1
Inflammatory fibroid polyps
Soft Tissues: Soft Tissue Leiomyosarcoma
HHAT/CD34 (1q32)
RPS6KC1/CD34 (1q32)

External links

Nomenclature
HGNC (Hugo)CD34   1662
Cards
Entrez_Gene (NCBI)CD34    CD34 molecule
Aliases
GeneCards (Weizmann)CD34
Ensembl hg19 (Hinxton)ENSG00000174059 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174059 [Gene_View]  ENSG00000174059 [Sequence]  chr1:207886538-207911125 [Contig_View]  CD34 [Vega]
ICGC DataPortalENSG00000174059
TCGA cBioPortalCD34
AceView (NCBI)CD34
Genatlas (Paris)CD34
SOURCE (Princeton)CD34
Genetics Home Reference (NIH)CD34
Genomic and cartography
GoldenPath hg38 (UCSC)CD34  -     chr1:207886538-207911125 -  1q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD34  -     1q32.2   [Description]    (hg19-Feb_2009)
GoldenPathCD34 - 1q32.2 [CytoView hg19]  CD34 - 1q32.2 [CytoView hg38]
ImmunoBaseENSG00000174059
genome Data Viewer NCBICD34 [Mapview hg19]  
OMIM142230   
Gene and transcription
Genbank (Entrez)AA022917 AF202879 AF523361 AF538601 AK091890
RefSeq transcript (Entrez)NM_001025109 NM_001773
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD34
Alternative Splicing GalleryENSG00000174059
Gene ExpressionCD34 [ NCBI-GEO ]   CD34 [ EBI - ARRAY_EXPRESS ]   CD34 [ SEEK ]   CD34 [ MEM ]
Gene Expression Viewer (FireBrowse)CD34 [ Firebrowse - Broad ]
GenevisibleExpression of CD34 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)947
GTEX Portal (Tissue expression)CD34
Human Protein AtlasENSG00000174059-CD34 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28906   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28906  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28906
Splice isoforms : SwissVarP28906
PhosPhoSitePlusP28906
Domains : Interpro (EBI)CD34    CD34/Podocalyxin   
Domain families : Pfam (Sanger)CD34_antigen (PF06365)   
Domain families : Pfam (NCBI)pfam06365   
Conserved Domain (NCBI)CD34
Blocks (Seattle)CD34
SuperfamilyP28906
Human Protein Atlas [tissue]ENSG00000174059-CD34 [tissue]
Peptide AtlasP28906
HPRD00790
IPIIPI00006070   IPI00299994   IPI00942062   IPI01010191   IPI00384949   
Protein Interaction databases
DIP (DOE-UCLA)P28906
IntAct (EBI)P28906
BioGRIDCD34
STRING (EMBL)CD34
ZODIACCD34
Ontologies - Pathways
QuickGOP28906
Ontology : AmiGOtissue homeostasis  endothelial cell proliferation  glomerular filtration  endothelium development  cytoplasm  lysosome  plasma membrane  plasma membrane  integral component of plasma membrane  cell-matrix adhesion  signal transduction  transcription factor binding  regulation of blood pressure  external side of plasma membrane  external side of plasma membrane  basal plasma membrane  positive regulation of gene expression  negative regulation of gene expression  apical plasma membrane  hemopoiesis  negative regulation of blood coagulation  carbohydrate binding  negative regulation of tumor necrosis factor production  positive regulation of interleukin-10 production  mesangial cell-matrix adhesion  glomerular endothelium fenestra  paracrine signaling  positive regulation of odontogenesis  sulfate binding  negative regulation of nitric oxide biosynthetic process  intercellular bridge  positive regulation of angiogenesis  perinuclear region of cytoplasm  cell motility  regulation of immune response  leukocyte migration  transdifferentiation  vascular wound healing  hematopoietic stem cell proliferation  positive regulation of transforming growth factor beta production  positive regulation of granulocyte colony-stimulating factor production  positive regulation of granulocyte colony-stimulating factor production  extracellular exosome assembly  glomerular endothelium development  stem cell proliferation  metanephric glomerular mesangial cell differentiation  cell-cell adhesion  negative regulation of cellular response to heat  negative regulation of cellular response to hypoxia  negative regulation of interleukin-2 secretion  positive regulation of glial cell-derived neurotrophic factor secretion  negative regulation of neuron death  positive regulation of vasculogenesis  
Ontology : EGO-EBItissue homeostasis  endothelial cell proliferation  glomerular filtration  endothelium development  cytoplasm  lysosome  plasma membrane  plasma membrane  integral component of plasma membrane  cell-matrix adhesion  signal transduction  transcription factor binding  regulation of blood pressure  external side of plasma membrane  external side of plasma membrane  basal plasma membrane  positive regulation of gene expression  negative regulation of gene expression  apical plasma membrane  hemopoiesis  negative regulation of blood coagulation  carbohydrate binding  negative regulation of tumor necrosis factor production  positive regulation of interleukin-10 production  mesangial cell-matrix adhesion  glomerular endothelium fenestra  paracrine signaling  positive regulation of odontogenesis  sulfate binding  negative regulation of nitric oxide biosynthetic process  intercellular bridge  positive regulation of angiogenesis  perinuclear region of cytoplasm  cell motility  regulation of immune response  leukocyte migration  transdifferentiation  vascular wound healing  hematopoietic stem cell proliferation  positive regulation of transforming growth factor beta production  positive regulation of granulocyte colony-stimulating factor production  positive regulation of granulocyte colony-stimulating factor production  extracellular exosome assembly  glomerular endothelium development  stem cell proliferation  metanephric glomerular mesangial cell differentiation  cell-cell adhesion  negative regulation of cellular response to heat  negative regulation of cellular response to hypoxia  negative regulation of interleukin-2 secretion  positive regulation of glial cell-derived neurotrophic factor secretion  negative regulation of neuron death  positive regulation of vasculogenesis  
Pathways : KEGGCell adhesion molecules (CAMs)    Hematopoietic cell lineage   
NDEx NetworkCD34
Atlas of Cancer Signalling NetworkCD34
Wikipedia pathwaysCD34
Orthology - Evolution
OrthoDB947
GeneTree (enSembl)ENSG00000174059
Phylogenetic Trees/Animal Genes : TreeFamCD34
HOGENOMP28906
Homologs : HomoloGeneCD34
Homology/Alignments : Family Browser (UCSC)CD34
Gene fusions - Rearrangements
Fusion : MitelmanHHAT/CD34 [1q32.2/1q32.2]  
Fusion : MitelmanRPS6KC1/CD34 [1q32.3/1q32.2]  
Fusion PortalHHAT 1q32.2 CD34 1q32.2 BRCA
Fusion PortalRPS6KC1 1q32.3 CD34 1q32.2 LUAD
Fusion : QuiverCD34
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD34 [hg38]
dbVarCD34
ClinVarCD34
MonarchCD34
1000_GenomesCD34 
Exome Variant ServerCD34
GNOMAD BrowserENSG00000174059
Varsome BrowserCD34
Genomic Variants (DGV)CD34 [DGVbeta]
DECIPHERCD34 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD34 
Mutations
ICGC Data PortalCD34 
TCGA Data PortalCD34 
Broad Tumor PortalCD34
OASIS PortalCD34 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD34  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCD34
Mutations and Diseases : HGMDCD34
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD34
DgiDB (Drug Gene Interaction Database)CD34
DoCM (Curated mutations)CD34 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD34 (select a term)
intoGenCD34
Cancer3DCD34(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142230   
Orphanet
DisGeNETCD34
MedgenCD34
Genetic Testing Registry CD34
NextProtP28906 [Medical]
GENETestsCD34
Target ValidationCD34
Huge Navigator CD34 [HugePedia]
ClinGenCD34
Clinical trials, drugs, therapy
MyCancerGenomeCD34
Protein Interactions : CTD
Pharm GKB GenePA26211
PharosP28906
Clinical trialCD34
Miscellaneous
canSAR (ICR)CD34 (select the gene name)
HarmonizomeCD34
DataMed IndexCD34
Probes
Litterature
PubMed331 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCD34
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:09:04 CET 2021
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