CD37 (CD37 molecule)

2003-11-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
GP52-40,TSPAN26
FUSION GENES

Other Information

Locus ID:

NCBI: 951
MIM: 151523
HGNC: 1666
Ensembl: ENSG00000104894

Variants:

dbSNP: 951
ClinVar: 951
TCGA: ENSG00000104894
COSMIC: CD37

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104894ENST00000323906P11049
ENSG00000104894ENST00000391859Q96LM7
ENSG00000104894ENST00000426897P11049
ENSG00000104894ENST00000535669B7ZAN3
ENSG00000104894ENST00000594743M0QZP6
ENSG00000104894ENST00000595660M0QZ33
ENSG00000104894ENST00000595725M0R1J1
ENSG00000104894ENST00000597602M0R083
ENSG00000104894ENST00000598095P11049

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
Hematopoietic cell lineageKEGGhsa04640

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
174400522007Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical.50
226247182012Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals.46
149780982004A regulatory role for CD37 in T cell proliferation.37
171825502007Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production.29
207099502010A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity.17
244458672014The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model.17
259347072015AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody-Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML.17
300896302018Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

CD37 (CD37 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/977/cd37