Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CD3E (CD3e molecule)

Identity

Alias_namesCD3e antigen, epsilon polypeptide (TiT3 complex)
CD3e molecule, epsilon (CD3-TCR complex)
Other aliasIMD18
T3E
TCRE
HGNC (Hugo) CD3E
LocusID (NCBI) 916
Atlas_Id 45585
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 118304580 and ends at 118316175 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CD3E (11q23.3) / ORAI2 (7q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CD3E   1674
LRG (Locus Reference Genomic)LRG_38
Cards
Entrez_Gene (NCBI)CD3E  916  CD3e molecule
AliasesIMD18; T3E; TCRE
GeneCards (Weizmann)CD3E
Ensembl hg19 (Hinxton)ENSG00000198851 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198851 [Gene_View]  chr11:118304580-118316175 [Contig_View]  CD3E [Vega]
ICGC DataPortalENSG00000198851
TCGA cBioPortalCD3E
AceView (NCBI)CD3E
Genatlas (Paris)CD3E
WikiGenes916
SOURCE (Princeton)CD3E
Genetics Home Reference (NIH)CD3E
Genomic and cartography
GoldenPath hg38 (UCSC)CD3E  -     chr11:118304580-118316175 +  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD3E  -     11q23.3   [Description]    (hg19-Feb_2009)
EnsemblCD3E - 11q23.3 [CytoView hg19]  CD3E - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBICD3E [Mapview hg19]  CD3E [Mapview hg38]
OMIM186830   615615   
Gene and transcription
Genbank (Entrez)AK292612 AK301255 AK311641 BC049847 BI910359
RefSeq transcript (Entrez)NM_000733
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD3E
Cluster EST : UnigeneHs.3003 [ NCBI ]
CGAP (NCI)Hs.3003
Alternative Splicing GalleryENSG00000198851
Gene ExpressionCD3E [ NCBI-GEO ]   CD3E [ EBI - ARRAY_EXPRESS ]   CD3E [ SEEK ]   CD3E [ MEM ]
Gene Expression Viewer (FireBrowse)CD3E [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)916
GTEX Portal (Tissue expression)CD3E
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07766   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07766  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07766
Splice isoforms : SwissVarP07766
PhosPhoSitePlusP07766
Domaine pattern : Prosite (Expaxy)ITAM_1 (PS51055)   
Domains : Interpro (EBI)CD3_esu/gsu/dsu    Ig-like_dom    Ig-like_fold    Ig_sub2    Phos_immunorcpt_sig_ITAM   
Domain families : Pfam (Sanger)ITAM (PF02189)   
Domain families : Pfam (NCBI)pfam02189   
Domain families : Smart (EMBL)IGc2 (SM00408)  ITAM (SM00077)  
Conserved Domain (NCBI)CD3E
DMDM Disease mutations916
Blocks (Seattle)CD3E
PDB (SRS)1A81    1SY6    1XIW    2ROL   
PDB (PDBSum)1A81    1SY6    1XIW    2ROL   
PDB (IMB)1A81    1SY6    1XIW    2ROL   
PDB (RSDB)1A81    1SY6    1XIW    2ROL   
Structural Biology KnowledgeBase1A81    1SY6    1XIW    2ROL   
SCOP (Structural Classification of Proteins)1A81    1SY6    1XIW    2ROL   
CATH (Classification of proteins structures)1A81    1SY6    1XIW    2ROL   
SuperfamilyP07766
Human Protein AtlasENSG00000198851
Peptide AtlasP07766
HPRD08923
IPIIPI00012923   IPI00978889   
Protein Interaction databases
DIP (DOE-UCLA)P07766
IntAct (EBI)P07766
FunCoupENSG00000198851
BioGRIDCD3E
STRING (EMBL)CD3E
ZODIACCD3E
Ontologies - Pathways
QuickGOP07766
Ontology : AmiGOimmunological synapse  positive regulation of T cell anergy  transmembrane signaling receptor activity  signal transducer activity, downstream of receptor  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  cell-cell junction  protein complex assembly  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  signal complex assembly  G-protein coupled receptor signaling pathway  response to nutrient  external side of plasma membrane  positive regulation of gene expression  negative regulation of gene expression  SH3 domain binding  protein kinase binding  receptor signaling complex scaffold activity  T cell costimulation  positive regulation of interferon-gamma production  positive regulation of interleukin-4 production  T cell receptor complex  T cell receptor complex  positive regulation of T cell proliferation  alpha-beta T cell receptor complex  T cell activation  T cell receptor binding  protein homodimerization activity  regulation of apoptotic process  negative thymic T cell selection  positive regulation of interleukin-2 biosynthetic process  negative regulation of smoothened signaling pathway  positive regulation of alpha-beta T cell proliferation  protein heterodimerization activity  positive regulation of peptidyl-tyrosine phosphorylation  regulation of immune response  positive regulation of calcium-mediated signaling  T cell receptor signaling pathway  protein homooligomerization  apoptotic signaling pathway  
Ontology : EGO-EBIimmunological synapse  positive regulation of T cell anergy  transmembrane signaling receptor activity  signal transducer activity, downstream of receptor  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  cell-cell junction  protein complex assembly  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  signal complex assembly  G-protein coupled receptor signaling pathway  response to nutrient  external side of plasma membrane  positive regulation of gene expression  negative regulation of gene expression  SH3 domain binding  protein kinase binding  receptor signaling complex scaffold activity  T cell costimulation  positive regulation of interferon-gamma production  positive regulation of interleukin-4 production  T cell receptor complex  T cell receptor complex  positive regulation of T cell proliferation  alpha-beta T cell receptor complex  T cell activation  T cell receptor binding  protein homodimerization activity  regulation of apoptotic process  negative thymic T cell selection  positive regulation of interleukin-2 biosynthetic process  negative regulation of smoothened signaling pathway  positive regulation of alpha-beta T cell proliferation  protein heterodimerization activity  positive regulation of peptidyl-tyrosine phosphorylation  regulation of immune response  positive regulation of calcium-mediated signaling  T cell receptor signaling pathway  protein homooligomerization  apoptotic signaling pathway  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGHematopoietic cell lineage    T cell receptor signaling pathway    Chagas disease (American trypanosomiasis)    Measles    HTLV-I infection    Primary immunodeficiency   
NDEx NetworkCD3E
Atlas of Cancer Signalling NetworkCD3E
Wikipedia pathwaysCD3E
Orthology - Evolution
OrthoDB916
GeneTree (enSembl)ENSG00000198851
Phylogenetic Trees/Animal Genes : TreeFamCD3E
HOVERGENP07766
HOGENOMP07766
Homologs : HomoloGeneCD3E
Homology/Alignments : Family Browser (UCSC)CD3E
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD3E [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD3E
dbVarCD3E
ClinVarCD3E
1000_GenomesCD3E 
Exome Variant ServerCD3E
ExAC (Exome Aggregation Consortium)CD3E (select the gene name)
Genetic variants : HAPMAP916
Genomic Variants (DGV)CD3E [DGVbeta]
DECIPHERCD3E [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD3E 
Mutations
ICGC Data PortalCD3E 
TCGA Data PortalCD3E 
Broad Tumor PortalCD3E
OASIS PortalCD3E [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD3E  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD3E
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch CD3E
DgiDB (Drug Gene Interaction Database)CD3E
DoCM (Curated mutations)CD3E (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD3E (select a term)
intoGenCD3E
Cancer3DCD3E(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186830    615615   
Orphanet17831   
MedgenCD3E
Genetic Testing Registry CD3E
NextProtP07766 [Medical]
TSGene916
GENETestsCD3E
Target ValidationCD3E
Huge Navigator CD3E [HugePedia]
snp3D : Map Gene to Disease916
BioCentury BCIQCD3E
ClinGenCD3E (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD916
Chemical/Pharm GKB GenePA26216
Clinical trialCD3E
Miscellaneous
canSAR (ICR)CD3E (select the gene name)
Probes
Litterature
PubMed138 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD3E
EVEXCD3E
GoPubMedCD3E
iHOPCD3E
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 16:57:16 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.