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CD3G (CD3g molecule)

Identity

Alias (NCBI)CD3-GAMMA
IMD17
T3G
HGNC (Hugo) CD3G
HGNC Previous nameCD3g antigen, gamma polypeptide (TiT3 complex)
 CD3g molecule, gamma (CD3-TCR complex)
LocusID (NCBI) 917
Atlas_Id 52425
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 118344344 and ends at 118355161 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD3G (11q23.3) / TRIM10 (6p22.1)FXYD6 (11q23.3) / CD3G (11q23.3)FXYD6 11q23.3 / CD3G 11q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CD3G   1675
LRG (Locus Reference Genomic)LRG_39
Cards
Entrez_Gene (NCBI)CD3G    CD3g molecule
AliasesCD3-GAMMA; IMD17; T3G
GeneCards (Weizmann)CD3G
Ensembl hg19 (Hinxton)ENSG00000160654 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160654 [Gene_View]  ENSG00000160654 [Sequence]  chr11:118344344-118355161 [Contig_View]  CD3G [Vega]
ICGC DataPortalENSG00000160654
TCGA cBioPortalCD3G
AceView (NCBI)CD3G
Genatlas (Paris)CD3G
SOURCE (Princeton)CD3G
Genetics Home Reference (NIH)CD3G
Genomic and cartography
GoldenPath hg38 (UCSC)CD3G  -     chr11:118344344-118355161 +  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD3G  -     11q23.3   [Description]    (hg19-Feb_2009)
GoldenPathCD3G - 11q23.3 [CytoView hg19]  CD3G - 11q23.3 [CytoView hg38]
ImmunoBaseENSG00000160654
Genome Data Viewer NCBICD3G [Mapview hg19]  
OMIM186740   615607   
Gene and transcription
Genbank (Entrez)AK223314 AK299997 AK310578 AK310622 AK313966
RefSeq transcript (Entrez)NM_000073
Consensus coding sequences : CCDS (NCBI)CD3G
Gene ExpressionCD3G [ NCBI-GEO ]   CD3G [ EBI - ARRAY_EXPRESS ]   CD3G [ SEEK ]   CD3G [ MEM ]
Gene Expression Viewer (FireBrowse)CD3G [ Firebrowse - Broad ]
GenevisibleExpression of CD3G in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)917
GTEX Portal (Tissue expression)CD3G
Human Protein AtlasENSG00000160654-CD3G [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09693   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09693  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09693
PhosPhoSitePlusP09693
Domaine pattern : Prosite (Expaxy)ITAM_1 (PS51055)   
Domains : Interpro (EBI)CD3_esu/gsu/dsu    Ig-like_dom_sf    Ig-like_fold    Ig_4    Ig_sub2    Phos_immunorcpt_sig_ITAM   
Domain families : Pfam (Sanger)Ig_4 (PF16680)    ITAM (PF02189)   
Domain families : Pfam (NCBI)pfam16680    pfam02189   
Domain families : Smart (EMBL)IGc2 (SM00408)  ITAM (SM00077)  
Conserved Domain (NCBI)CD3G
PDB (RSDB)1SY6    6JXR   
PDB Europe1SY6    6JXR   
PDB (PDBSum)1SY6    6JXR   
PDB (IMB)1SY6    6JXR   
Structural Biology KnowledgeBase1SY6    6JXR   
SCOP (Structural Classification of Proteins)1SY6    6JXR   
CATH (Classification of proteins structures)1SY6    6JXR   
SuperfamilyP09693
AlphaFold pdb e-kbP09693   
Human Protein Atlas [tissue]ENSG00000160654-CD3G [tissue]
HPRD07037
Protein Interaction databases
DIP (DOE-UCLA)P09693
IntAct (EBI)P09693
BioGRIDCD3G
STRING (EMBL)CD3G
ZODIACCD3G
Ontologies - Pathways
QuickGOP09693
Ontology : AmiGOadaptive immune response  negative regulation of inflammatory response to antigenic stimulus  transmembrane signaling receptor activity  transmembrane signaling receptor activity  transmembrane signaling receptor activity  protein binding  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  establishment or maintenance of cell polarity  cell surface receptor signaling pathway  cell surface receptor signaling pathway  cell surface receptor signaling pathway  external side of plasma membrane  protein transport  peptide cross-linking  signaling receptor complex adaptor activity  clathrin-coated endocytic vesicle membrane  Fc-gamma receptor signaling pathway involved in phagocytosis  alpha-beta T cell receptor complex  alpha-beta T cell receptor complex  T cell activation  T cell receptor binding  identical protein binding  positive thymic T cell selection  regulation of immune response  T cell receptor signaling pathway  membrane organization  protein-containing complex assembly  regulation of lymphocyte apoptotic process  
Ontology : EGO-EBIadaptive immune response  negative regulation of inflammatory response to antigenic stimulus  transmembrane signaling receptor activity  transmembrane signaling receptor activity  transmembrane signaling receptor activity  protein binding  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  establishment or maintenance of cell polarity  cell surface receptor signaling pathway  cell surface receptor signaling pathway  cell surface receptor signaling pathway  external side of plasma membrane  protein transport  peptide cross-linking  signaling receptor complex adaptor activity  clathrin-coated endocytic vesicle membrane  Fc-gamma receptor signaling pathway involved in phagocytosis  alpha-beta T cell receptor complex  alpha-beta T cell receptor complex  T cell activation  T cell receptor binding  identical protein binding  positive thymic T cell selection  regulation of immune response  T cell receptor signaling pathway  membrane organization  protein-containing complex assembly  regulation of lymphocyte apoptotic process  
Pathways : BIOCARTAT Cell Receptor Signaling Pathway [Genes]    Role of Tob in T-cell activation [Genes]    T Helper Cell Surface Molecules [Genes]    Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor [Genes]    The Co-Stimulatory Signal During T-cell Activation [Genes]    CTL mediated immune response against target cells [Genes]    T Cytotoxic Cell Surface Molecules [Genes]    Lck and Fyn tyrosine kinases in initiation of TCR Activation [Genes]    HIV Induced T Cell Apoptosis [Genes]    Stathmin and breast cancer resistance to antimicrotubule agents [Genes]    IL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]    IL 17 Signaling Pathway [Genes]    T Cell Receptor and CD3 Complex [Genes]   
Pathways : KEGGHematopoietic cell lineage    T cell receptor signaling pathway    Chagas disease (American trypanosomiasis)    Measles    HTLV-I infection   
NDEx NetworkCD3G
Atlas of Cancer Signalling NetworkCD3G
Wikipedia pathwaysCD3G
Orthology - Evolution
OrthoDB917
GeneTree (enSembl)ENSG00000160654
Phylogenetic Trees/Animal Genes : TreeFamCD3G
Homologs : HomoloGeneCD3G
Homology/Alignments : Family Browser (UCSC)CD3G
Gene fusions - Rearrangements
Fusion : MitelmanFXYD6/CD3G [11q23.3/11q23.3]  
Fusion : QuiverCD3G
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD3G [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD3G
dbVarCD3G
ClinVarCD3G
MonarchCD3G
1000_GenomesCD3G 
Exome Variant ServerCD3G
GNOMAD BrowserENSG00000160654
Varsome BrowserCD3G
ACMGCD3G variants
VarityP09693
Genomic Variants (DGV)CD3G [DGVbeta]
DECIPHERCD3G [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD3G 
Mutations
ICGC Data PortalCD3G 
TCGA Data PortalCD3G 
Broad Tumor PortalCD3G
OASIS PortalCD3G [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD3G  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCD3G
Mutations and Diseases : HGMDCD3G
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCD3G
DgiDB (Drug Gene Interaction Database)CD3G
DoCM (Curated mutations)CD3G
CIViC (Clinical Interpretations of Variants in Cancer)CD3G
Cancer3DCD3G
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186740    615607   
Orphanet17816   
DisGeNETCD3G
MedgenCD3G
Genetic Testing Registry CD3G
NextProtP09693 [Medical]
GENETestsCD3G
Target ValidationCD3G
Huge Navigator CD3G [HugePedia]
ClinGenCD3G
Clinical trials, drugs, therapy
MyCancerGenomeCD3G
Protein Interactions : CTDCD3G
Pharm GKB GenePA26217
PharosP09693
Clinical trialCD3G
Miscellaneous
canSAR (ICR)CD3G
HarmonizomeCD3G
DataMed IndexCD3G
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCD3G
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:02:59 CEST 2021

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