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CD40 (CD40 molecule, TNF receptor superfamily member 5)

Identity

Other namesBp50
CDW40
TNFRSF5
p50
HGNC (Hugo) CD40
LocusID (NCBI) 958
Location 20q13.12
Location_base_pair Starts at 44746906 and ends at 44758384 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CD40   11919
Entrez_Gene (NCBI)CD40  958  CD40 molecule, TNF receptor superfamily member 5
Cards
GeneCards (Weizmann)CD40
Ensembl (Hinxton)ENSG00000101017 [Gene_View]  chr20:44746906-44758384 [Contig_View]  CD40 [Vega]
AceView (NCBI)CD40
Genatlas (Paris)CD40
SOURCE (Stanford)NM_001250 NM_152854
Genomic and cartography
GoldenPath (UCSC)CD40  -  20q13.12   chr20:44746906-44758384 +  20q13.12   [Description]    (hg19-Feb_2009)
EnsemblCD40 - 20q13.12 [CytoView]
Mapping of homologs : NCBICD40 [Mapview]
OMIM109535   606843   
Gene and transcription
Genbank (Entrez)AB209660 AJ300189 AK222896 AY225405 BC012419
RefSeq transcript (SRS)NM_001250 NM_152854
RefSeq transcript (Entrez)NM_001250 NM_152854
RefSeq genomic (SRS)AC_000152 NC_000020 NC_018931 NG_007279 NT_011362 NW_001838666 NW_004078102
RefSeq genomic (Entrez)AC_000152 NC_000020 NC_018931 NG_007279 NT_011362 NW_001838666 NW_004078102
Consensus coding sequences : CCDS (NCBI)CD40
Cluster EST : UnigeneHs.472860 [ SRS ] Hs.472860 [ NCBI ]
CGAP (NCI)Hs.472860
Alternative Splicing : Fast-db (Paris)GSHG0018798
Alternative Splicing GalleryENSG00000101017
Gene ExpressionCD40 [ NCBI-GEO ]   CD40 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25942 (SRS) P25942 (Uniprot)
NextProtP25942
With graphics : InterProP25942
Splice isoforms : SwissVarP25942(Swissvar)
Domaine pattern : Prosite (SRS)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (SRS)TNFR/NGFR_Cys_rich_reg    TNFR_5   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_5   
Related proteins : CluSTrP25942
Domain families : Pfam (SRS)TNFR_c6 (PF00020)   
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
DMDM958
Blocks (Seattle)P25942
PDB (SRS)1CDF    1CZZ    1D00    1FLL    1LB6    3QD6   
PDB (PDBSum)1CDF    1CZZ    1D00    1FLL    1LB6    3QD6   
PDB (IMB)1CDF    1CZZ    1D00    1FLL    1LB6    3QD6   
PDB (RSDB)1CDF    1CZZ    1D00    1FLL    1LB6    3QD6   
Human Protein AtlasENSG00000101017
HPRD00178
IPIIPI00018282   IPI00218464   IPI00556230   IPI00980079   
Protein Interaction databases
DIP (DOE-UCLA)P25942
IntAct (EBI)P25942
FunCoupENSG00000101017
REACTOMECD40
Protein Interaction Database958
BioGRIDCD40
InParanoidP25942
Interologous Interaction database P25942
IntegromeDBCD40
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CD40
SNP (GeneSNP Utah)CD40
SNP : HGBaseCD40
Genetic variants : HAPMAPCD40
Somatic Mutations in Cancer : COSMICCD40 
CONAN: Copy Number AnalysisCD40 
Mutations and Diseases : HGMDCD40
OMIM109535    606843   
GENETests109535    606843   
Disease Genetic AssociationCD40
Huge Navigator CD40 [HugePedia]  CD40 [HugeCancerGEM]
Genomic VariantsCD40  CD40 [DGVbeta]
snp3D : Map Gene to Disease958
General knowledge
Homologs : HomoloGeneCD40
Homology/Alignments : Family Browser (UCSC)CD40
Phylogenetic Trees/Animal Genes : TreeFamCD40
Chemical/Protein Interactions : CTD958
Chemical/Pharm GKB GenePA36612
Clinical trialCD40
Cancer Resource (Charite)ENSG00000101017
Ontology : AmiGOpositive regulation of protein phosphorylation  immune response-regulating cell surface receptor signaling pathway  signal transducer activity  receptor activity  protein binding  extracellular region  plasma membrane  plasma membrane  integral to plasma membrane  protein complex assembly  cellular calcium ion homeostasis  inflammatory response  external side of plasma membrane  enzyme binding  platelet activation  positive regulation of B cell proliferation  ubiquitin protein ligase binding  positive regulation of interleukin-12 production  positive regulation of Rac GTPase activity  CD40 receptor complex  B cell proliferation  positive regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of Cdc42 GTPase activity  positive regulation of I-kappaB kinase/NF-kappaB cascade  intracellular membrane-bounded organelle  positive regulation of MAP kinase activity  positive regulation of transcription from RNA polymerase II promoter  positive regulation of isotype switching to IgG isotypes  regulation of immune response  regulation of immunoglobulin secretion  positive regulation of NF-kappaB transcription factor activity  defense response to virus  cellular response to mechanical stimulus  positive regulation of protein kinase C signaling cascade  positive regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  immune response-regulating cell surface receptor signaling pathway  signal transducer activity  receptor activity  protein binding  extracellular region  plasma membrane  plasma membrane  integral to plasma membrane  protein complex assembly  cellular calcium ion homeostasis  inflammatory response  external side of plasma membrane  enzyme binding  platelet activation  positive regulation of B cell proliferation  ubiquitin protein ligase binding  positive regulation of interleukin-12 production  positive regulation of Rac GTPase activity  CD40 receptor complex  B cell proliferation  positive regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of Cdc42 GTPase activity  positive regulation of I-kappaB kinase/NF-kappaB cascade  intracellular membrane-bounded organelle  positive regulation of MAP kinase activity  positive regulation of transcription from RNA polymerase II promoter  positive regulation of isotype switching to IgG isotypes  regulation of immune response  regulation of immunoglobulin secretion  positive regulation of NF-kappaB transcription factor activity  defense response to virus  cellular response to mechanical stimulus  positive regulation of protein kinase C signaling cascade  positive regulation of endothelial cell apoptotic process  
Pathways : BIOCARTAAntigen Dependent B Cell Activation [Genes]    Th1/Th2 Differentiation [Genes]    Dendritic cells in regulating TH1 and TH2 Development [Genes]    Bystander B Cell Activation [Genes]    CD40L Signaling Pathway [Genes]    B Lymphocyte Cell Surface Molecules [Genes]   
Pathways : KEGGCell adhesion molecules (CAMs)Toll-like receptor signaling pathwayCytokine-cytokine receptor interaction
Other databases
Probes
Litterature
PubMed422 Pubmed reference(s) in Entrez
PubGeneCD40
iHOPCD40
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:28:56 CEST 2013
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