CD40 (CD40 molecule)

2003-06-01  

Identity

HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
Bp50,CDW40,TNFRSF5,p50
FUSION GENES

Other Information

Locus ID:

NCBI: 958
MIM: 109535
HGNC: 11919
Ensembl: ENSG00000101017

Variants:

dbSNP: 958
ClinVar: 958
TCGA: ENSG00000101017
COSMIC: CD40

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101017ENST00000372276P25942
ENSG00000101017ENST00000372285P25942
ENSG00000101017ENST00000372285A0A0S2Z3C7
ENSG00000101017ENST00000466205H0YE23
ENSG00000101017ENST00000620709A0A087X1D0

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cell adhesion molecules (CAMs)KEGGko04514
Toll-like receptor signaling pathwayKEGGko04620
AsthmaKEGGko05310
Autoimmune thyroid diseaseKEGGko05320
Systemic lupus erythematosusKEGGko05322
Allograft rejectionKEGGko05330
Primary immunodeficiencyKEGGko05340
Cytokine-cytokine receptor interactionKEGGhsa04060
Cell adhesion molecules (CAMs)KEGGhsa04514
Toll-like receptor signaling pathwayKEGGhsa04620
AsthmaKEGGhsa05310
Autoimmune thyroid diseaseKEGGhsa05320
Systemic lupus erythematosusKEGGhsa05322
Allograft rejectionKEGGhsa05330
Primary immunodeficiencyKEGGhsa05340
Viral myocarditisKEGGhsa05416
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
MalariaKEGGko05144
MalariaKEGGhsa05144
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
187948532008Common variants at CD40 and other loci confer risk of rheumatoid arthritis.199
187948532008Common variants at CD40 and other loci confer risk of rheumatoid arthritis.199
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
224469622012A genome-wide association study identifies three new risk loci for Kawasaki disease.95
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
191105362009Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.82
146177522003Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions.67
126768202003CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation.57
117519742002Ceramide-rich membrane rafts mediate CD40 clustering.56
153314432004Tracking CD40 signaling during germinal center development.55

Citation

Dessen P

CD40 (CD40 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42627/cd40