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CD40LG (CD40 ligand)

Identity

Other namesCD154
CD40L
HIGM1
IGM
IMD3
T-BAM
TNFSF5
TRAP
gp39
hCD40L
HGNC (Hugo) CD40LG
LocusID (NCBI) 959
Location Xq26.3
Location_base_pair Starts at 135730336 and ends at 135742549 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CD40LG   11935
Cards
Entrez_Gene (NCBI)CD40LG  959  CD40 ligand
GeneCards (Weizmann)CD40LG
Ensembl (Hinxton)ENSG00000102245 [Gene_View]  chrX:135730336-135742549 [Contig_View]  CD40LG [Vega]
ICGC DataPortalENSG00000102245
AceView (NCBI)CD40LG
Genatlas (Paris)CD40LG
WikiGenes959
SOURCE (Princeton)NM_000074
Genomic and cartography
GoldenPath (UCSC)CD40LG  -  Xq26.3   chrX:135730336-135742549 +  Xq26.3   [Description]    (hg19-Feb_2009)
EnsemblCD40LG - Xq26.3 [CytoView]
Mapping of homologs : NCBICD40LG [Mapview]
OMIM300386   308230   
Gene and transcription
Genbank (Entrez)AF529195 AK292637 AY197739 BC071754 BC074950
RefSeq transcript (Entrez)NM_000074
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_007280 NT_011786 NW_001842404 NW_004929446
Consensus coding sequences : CCDS (NCBI)CD40LG
Cluster EST : UnigeneHs.592244 [ NCBI ]
CGAP (NCI)Hs.592244
Alternative Splicing : Fast-db (Paris)GSHG0031842
Alternative Splicing GalleryENSG00000102245
Gene ExpressionCD40LG [ NCBI-GEO ]     CD40LG [ SEEK ]   CD40LG [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29965 (Uniprot)
NextProtP29965  [Medical]
With graphics : InterProP29965
Splice isoforms : SwissVarP29965 (Swissvar)
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)    TNF_2 (PS50049)   
Domains : Interpro (EBI)TNF_CS    TNF_dom    TNF_ligand_5    Tumour_necrosis_fac-like_dom   
Related proteins : CluSTrP29965
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
DMDM Disease mutations959
Blocks (Seattle)P29965
PDB (SRS)1ALY    1I9R    3LKJ    3QD6   
PDB (PDBSum)1ALY    1I9R    3LKJ    3QD6   
PDB (IMB)1ALY    1I9R    3LKJ    3QD6   
PDB (RSDB)1ALY    1I9R    3LKJ    3QD6   
Human Protein AtlasENSG00000102245
Peptide AtlasP29965
HPRD02311
IPIIPI00024686   IPI00643618   
Protein Interaction databases
DIP (DOE-UCLA)P29965
IntAct (EBI)P29965
FunCoupENSG00000102245
BioGRIDCD40LG
InParanoidP29965
Interologous Interaction database P29965
IntegromeDBCD40LG
STRING (EMBL)CD40LG
Ontologies - Pathways
Ontology : AmiGOcytokine activity  tumor necrosis factor receptor binding  CD40 receptor binding  extracellular space  plasma membrane  integral component of plasma membrane  inflammatory response  leukocyte cell-cell adhesion  external side of plasma membrane  integral component of membrane  platelet activation  B cell differentiation  positive regulation of interleukin-12 production  B cell proliferation  negative regulation of apoptotic process  isotype switching  immunoglobulin secretion  regulation of immune response  regulation of immunoglobulin secretion  positive regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIcytokine activity  tumor necrosis factor receptor binding  CD40 receptor binding  extracellular space  plasma membrane  integral component of plasma membrane  inflammatory response  leukocyte cell-cell adhesion  external side of plasma membrane  integral component of membrane  platelet activation  B cell differentiation  positive regulation of interleukin-12 production  B cell proliferation  negative regulation of apoptotic process  isotype switching  immunoglobulin secretion  regulation of immune response  regulation of immunoglobulin secretion  positive regulation of endothelial cell apoptotic process  
Pathways : BIOCARTAAntigen Dependent B Cell Activation [Genes]    CD40L Signaling Pathway [Genes]    Th1/Th2 Differentiation [Genes]    Bystander B Cell Activation [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    NF-kappa B signaling pathway    Cell adhesion molecules (CAMs)    T cell receptor signaling pathway    Intestinal immune network for IgA production    Malaria    Toxoplasmosis    Asthma    Autoimmune thyroid disease    Systemic lupus erythematosus    Allograft rejection    Primary immunodeficiency    Viral myocarditis   
Protein Interaction DatabaseCD40LG
Wikipedia pathwaysCD40LG
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CD40LG
SNP (GeneSNP Utah)CD40LG
SNP : HGBaseCD40LG
Genetic variants : HAPMAPCD40LG
1000_GenomesCD40LG 
ICGC programENSG00000102245 
CONAN: Copy Number AnalysisCD40LG 
Somatic Mutations in Cancer : COSMICCD40LG 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
Mutations and Diseases : HGMDCD40LG
OMIM300386    308230   
MedgenCD40LG
GENETestsCD40LG
Disease Genetic AssociationCD40LG
Huge Navigator CD40LG [HugePedia]  CD40LG [HugeCancerGEM]
Genomic VariantsCD40LG  CD40LG [DGVbeta]
Exome VariantCD40LG
dbVarCD40LG
ClinVarCD40LG
snp3D : Map Gene to Disease959
General knowledge
Homologs : HomoloGeneCD40LG
Homology/Alignments : Family Browser (UCSC)CD40LG
Phylogenetic Trees/Animal Genes : TreeFamCD40LG
Chemical/Protein Interactions : CTD959
Chemical/Pharm GKB GenePA36626
Clinical trialCD40LG
Cancer Resource (Charite)ENSG00000102245
Other databases
Probes
Litterature
PubMed396 Pubmed reference(s) in Entrez
CoreMineCD40LG
iHOPCD40LG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:37:33 CEST 2014

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