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CD40LG (CD40 ligand)

Identity

Other namesCD154
CD40L
HIGM1
IGM
IMD3
T-BAM
TNFSF5
TRAP
gp39
hCD40L
HGNC (Hugo) CD40LG
LocusID (NCBI) 959
Atlas_Id 45508
Location Xq26.3  [Link to chromosome band Xq26]
Location_base_pair Starts at 135730336 and ends at 135742549 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CD40LG   11935
Cards
Entrez_Gene (NCBI)CD40LG  959  CD40 ligand
AliasesCD154; CD40L; HIGM1; IGM; 
IMD3; T-BAM; TNFSF5; TRAP; gp39; hCD40L
GeneCards (Weizmann)CD40LG
Ensembl hg19 (Hinxton)ENSG00000102245 [Gene_View]  chrX:135730336-135742549 [Contig_View]  CD40LG [Vega]
Ensembl hg38 (Hinxton)ENSG00000102245 [Gene_View]  chrX:135730336-135742549 [Contig_View]  CD40LG [Vega]
ICGC DataPortalENSG00000102245
TCGA cBioPortalCD40LG
AceView (NCBI)CD40LG
Genatlas (Paris)CD40LG
WikiGenes959
SOURCE (Princeton)CD40LG
Genomic and cartography
GoldenPath hg19 (UCSC)CD40LG  -     chrX:135730336-135742549 +  Xq26.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CD40LG  -     Xq26.3   [Description]    (hg38-Dec_2013)
EnsemblCD40LG - Xq26.3 [CytoView hg19]  CD40LG - Xq26.3 [CytoView hg38]
Mapping of homologs : NCBICD40LG [Mapview hg19]  CD40LG [Mapview hg38]
OMIM300386   308230   
Gene and transcription
Genbank (Entrez)AF529195 AK292637 AY197739 BC071754 BC074950
RefSeq transcript (Entrez)NM_000074
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_007280 NT_011786 NW_004929446
Consensus coding sequences : CCDS (NCBI)CD40LG
Cluster EST : UnigeneHs.592244 [ NCBI ]
CGAP (NCI)Hs.592244
Alternative Splicing GalleryENSG00000102245
Gene ExpressionCD40LG [ NCBI-GEO ]   CD40LG [ EBI - ARRAY_EXPRESS ]   CD40LG [ SEEK ]   CD40LG [ MEM ]
Gene Expression Viewer (FireBrowse)CD40LG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)959
GTEX Portal (Tissue expression)CD40LG
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29965 (Uniprot)
NextProtP29965  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29965
Splice isoforms : SwissVarP29965 (Swissvar)
PhosPhoSitePlusP29965
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)    TNF_2 (PS50049)   
Domains : Interpro (EBI)CD40L    TNF_CS    TNF_dom    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
DMDM Disease mutations959
Blocks (Seattle)CD40LG
PDB (SRS)1ALY    1I9R    3LKJ    3QD6   
PDB (PDBSum)1ALY    1I9R    3LKJ    3QD6   
PDB (IMB)1ALY    1I9R    3LKJ    3QD6   
PDB (RSDB)1ALY    1I9R    3LKJ    3QD6   
Structural Biology KnowledgeBase1ALY    1I9R    3LKJ    3QD6   
SCOP (Structural Classification of Proteins)1ALY    1I9R    3LKJ    3QD6   
CATH (Classification of proteins structures)1ALY    1I9R    3LKJ    3QD6   
SuperfamilyP29965
Human Protein AtlasENSG00000102245
Peptide AtlasP29965
HPRD02311
IPIIPI00024686   IPI00643618   
Protein Interaction databases
DIP (DOE-UCLA)P29965
IntAct (EBI)P29965
FunCoupENSG00000102245
BioGRIDCD40LG
STRING (EMBL)CD40LG
ZODIACCD40LG
Ontologies - Pathways
QuickGOP29965
Ontology : AmiGOcytokine activity  tumor necrosis factor receptor binding  CD40 receptor binding  protein binding  extracellular space  intracellular  plasma membrane  integral component of plasma membrane  inflammatory response  leukocyte cell-cell adhesion  activation of JUN kinase activity  external side of plasma membrane  cell surface  integral component of membrane  platelet activation  B cell differentiation  T cell costimulation  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-4 production  tumor necrosis factor-mediated signaling pathway  B cell proliferation  positive regulation of T cell proliferation  negative regulation of apoptotic process  isotype switching  immunoglobulin secretion  regulation of immune response  regulation of immunoglobulin secretion  positive regulation of NF-kappaB transcription factor activity  positive regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIcytokine activity  tumor necrosis factor receptor binding  CD40 receptor binding  protein binding  extracellular space  intracellular  plasma membrane  integral component of plasma membrane  inflammatory response  leukocyte cell-cell adhesion  activation of JUN kinase activity  external side of plasma membrane  cell surface  integral component of membrane  platelet activation  B cell differentiation  T cell costimulation  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-4 production  tumor necrosis factor-mediated signaling pathway  B cell proliferation  positive regulation of T cell proliferation  negative regulation of apoptotic process  isotype switching  immunoglobulin secretion  regulation of immune response  regulation of immunoglobulin secretion  positive regulation of NF-kappaB transcription factor activity  positive regulation of endothelial cell apoptotic process  
Pathways : BIOCARTAAntigen Dependent B Cell Activation [Genes]    CD40L Signaling Pathway [Genes]    Th1/Th2 Differentiation [Genes]    Bystander B Cell Activation [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    NF-kappa B signaling pathway    Cell adhesion molecules (CAMs)    T cell receptor signaling pathway    Intestinal immune network for IgA production    Malaria    Toxoplasmosis    Asthma    Autoimmune thyroid disease    Systemic lupus erythematosus    Allograft rejection    Primary immunodeficiency    Viral myocarditis   
NDEx NetworkCD40LG
Atlas of Cancer Signalling NetworkCD40LG
Wikipedia pathwaysCD40LG
Orthology - Evolution
OrthoDB959
GeneTree (enSembl)ENSG00000102245
Phylogenetic Trees/Animal Genes : TreeFamCD40LG
Homologs : HomoloGeneCD40LG
Homology/Alignments : Family Browser (UCSC)CD40LG
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCD40LG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD40LG
dbVarCD40LG
ClinVarCD40LG
1000_GenomesCD40LG 
Exome Variant ServerCD40LG
ExAC (Exome Aggregation Consortium)CD40LG (select the gene name)
Genetic variants : HAPMAP959
Genomic Variants (DGV)CD40LG [DGVbeta]
Mutations
ICGC Data PortalCD40LG 
TCGA Data PortalCD40LG 
Broad Tumor PortalCD40LG
OASIS PortalCD40LG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD40LG 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch CD40LG
DgiDB (Drug Gene Interaction Database)CD40LG
DoCM (Curated mutations)CD40LG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD40LG (select a term)
intoGenCD40LG
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:135730336-135742549  ENSG00000102245
CONAN: Copy Number AnalysisCD40LG 
Mutations and Diseases : HGMDCD40LG
OMIM300386    308230   
MedgenCD40LG
Genetic Testing Registry CD40LG
NextProtP29965 [Medical]
TSGene959
GENETestsCD40LG
Huge Navigator CD40LG [HugePedia]
snp3D : Map Gene to Disease959
BioCentury BCIQCD40LG
ClinGenCD40LG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD959
Chemical/Pharm GKB GenePA36626
Clinical trialCD40LG
Miscellaneous
canSAR (ICR)CD40LG (select the gene name)
Probes
Litterature
PubMed445 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD40LG
EVEXCD40LG
GoPubMedCD40LG
iHOPCD40LG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 18:41:09 CEST 2016

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