CD5 (CD5 molecule)

2007-02-01  

Identity

HGNC
CD5
LOCATION
11q12.2
LOCUSID
921
ALIAS
LEU1,T1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 921
MIM: 153340
HGNC: 1685
Ensembl: ENSG00000110448

Variants:

dbSNP: 921
ClinVar: 921
TCGA: ENSG00000110448
COSMIC: CD5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110448ENST00000347785P06127
ENSG00000110448ENST00000544014F5GYK3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
Hematopoietic cell lineageKEGGhsa04640

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
118616042002Origins and functions of B-1 cells with notes on the role of CD5.200
123934192002Human CD5 promotes B-cell survival through stimulation of autocrine IL-10 production.50
191416312009The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome.35
127073402003CD5 inhibits signaling at the immunological synapse without impairing its formation.28
229042992012CD5-dependent CK2 activation pathway regulates threshold for T cell anergy.23
185564022008De novo CD5+ diffuse large B-cell lymphoma: results of a detailed clinicopathological review in 120 patients.21
219263482011CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation.21
213986172011CD5 promotes IL-10 production in chronic lymphocytic leukemia B cells through STAT3 and NFAT2 activation.20
222782272012Hepatitis C virus infection of human T lymphocytes is mediated by CD5.18
178783282007Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.17

Citation

Dessen P

CD5 (CD5 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46449/cd5