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CD6 (CD6 molecule)

Identity

Alias (NCBI)TP120
HGNC (Hugo) CD6
HGNC Alias symbTp120
HGNC Previous nameCD6 antigen
LocusID (NCBI) 923
Atlas_Id 45784
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 60971680 and ends at 61020376 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CD6   1691
Cards
Entrez_Gene (NCBI)CD6    CD6 molecule
AliasesTP120
GeneCards (Weizmann)CD6
Ensembl hg19 (Hinxton)ENSG00000013725 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000013725 [Gene_View]  ENSG00000013725 [Sequence]  chr11:60971680-61020376 [Contig_View]  CD6 [Vega]
ICGC DataPortalENSG00000013725
TCGA cBioPortalCD6
AceView (NCBI)CD6
Genatlas (Paris)CD6
SOURCE (Princeton)CD6
Genetics Home Reference (NIH)CD6
Genomic and cartography
GoldenPath hg38 (UCSC)CD6  -     chr11:60971680-61020376 +  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD6  -     11q12.2   [Description]    (hg19-Feb_2009)
GoldenPathCD6 - 11q12.2 [CytoView hg19]  CD6 - 11q12.2 [CytoView hg38]
ImmunoBaseENSG00000013725
Genome Data Viewer NCBICD6 [Mapview hg19]  
OMIM186720   
Gene and transcription
Genbank (Entrez)AI657093 AK126159 AK128419 AK292704 AK312749
RefSeq transcript (Entrez)NM_001254750 NM_001254751 NM_006725
Consensus coding sequences : CCDS (NCBI)CD6
Gene ExpressionCD6 [ NCBI-GEO ]   CD6 [ EBI - ARRAY_EXPRESS ]   CD6 [ SEEK ]   CD6 [ MEM ]
Gene Expression Viewer (FireBrowse)CD6 [ Firebrowse - Broad ]
GenevisibleExpression of CD6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)923
GTEX Portal (Tissue expression)CD6
Human Protein AtlasENSG00000013725-CD6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30203   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30203  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30203
PhosPhoSitePlusP30203
Domaine pattern : Prosite (Expaxy)SRCR_1 (PS00420)    SRCR_2 (PS50287)   
Domains : Interpro (EBI)SRCR    SRCR-like_dom    SRCR-like_dom_sf   
Domain families : Pfam (Sanger)SRCR (PF00530)   
Domain families : Pfam (NCBI)pfam00530   
Domain families : Smart (EMBL)SR (SM00202)  
Conserved Domain (NCBI)CD6
PDB (RSDB)5A2E   
PDB Europe5A2E   
PDB (PDBSum)5A2E   
PDB (IMB)5A2E   
Structural Biology KnowledgeBase5A2E   
SCOP (Structural Classification of Proteins)5A2E   
CATH (Classification of proteins structures)5A2E   
SuperfamilyP30203
AlphaFold pdb e-kbP30203   
Human Protein Atlas [tissue]ENSG00000013725-CD6 [tissue]
HPRD01724
Protein Interaction databases
DIP (DOE-UCLA)P30203
IntAct (EBI)P30203
BioGRIDCD6
STRING (EMBL)CD6
ZODIACCD6
Ontologies - Pathways
QuickGOP30203
Ontology : AmiGOlipopolysaccharide binding  immunological synapse formation  immunological synapse  adaptive immune response  acute inflammatory response to antigenic stimulus  scavenger receptor activity  protein binding  extracellular region  integral component of plasma membrane  endocytosis  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  external side of plasma membrane  intrinsic component of plasma membrane  lipopolysaccharide-mediated signaling pathway  response to lipopolysaccharide  positive regulation of T cell proliferation  identical protein binding  innate immune response  lipoteichoic acid binding  positive regulation of cytokine production involved in inflammatory response  
Ontology : EGO-EBIlipopolysaccharide binding  immunological synapse formation  immunological synapse  adaptive immune response  acute inflammatory response to antigenic stimulus  scavenger receptor activity  protein binding  extracellular region  integral component of plasma membrane  endocytosis  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  external side of plasma membrane  intrinsic component of plasma membrane  lipopolysaccharide-mediated signaling pathway  response to lipopolysaccharide  positive regulation of T cell proliferation  identical protein binding  innate immune response  lipoteichoic acid binding  positive regulation of cytokine production involved in inflammatory response  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkCD6
Atlas of Cancer Signalling NetworkCD6
Wikipedia pathwaysCD6
Orthology - Evolution
OrthoDB923
GeneTree (enSembl)ENSG00000013725
Phylogenetic Trees/Animal Genes : TreeFamCD6
Homologs : HomoloGeneCD6
Homology/Alignments : Family Browser (UCSC)CD6
Gene fusions - Rearrangements
Fusion : QuiverCD6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD6
dbVarCD6
ClinVarCD6
MonarchCD6
1000_GenomesCD6 
Exome Variant ServerCD6
GNOMAD BrowserENSG00000013725
Varsome BrowserCD6
ACMGCD6 variants
VarityP30203
Genomic Variants (DGV)CD6 [DGVbeta]
DECIPHERCD6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD6 
Mutations
ICGC Data PortalCD6 
TCGA Data PortalCD6 
Broad Tumor PortalCD6
OASIS PortalCD6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCD6
Mutations and Diseases : HGMDCD6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCD6
DgiDB (Drug Gene Interaction Database)CD6
DoCM (Curated mutations)CD6
CIViC (Clinical Interpretations of Variants in Cancer)CD6
Cancer3DCD6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186720   
Orphanet
DisGeNETCD6
MedgenCD6
Genetic Testing Registry CD6
NextProtP30203 [Medical]
GENETestsCD6
Target ValidationCD6
Huge Navigator CD6 [HugePedia]
ClinGenCD6
Clinical trials, drugs, therapy
MyCancerGenomeCD6
Protein Interactions : CTDCD6
Pharm GKB GenePA26230
PharosP30203
Clinical trialCD6
Miscellaneous
canSAR (ICR)CD6
HarmonizomeCD6
DataMed IndexCD6
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCD6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:03:02 CEST 2021

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