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CD68 (CD68 molecule)

Identity

Alias_namesCD68 antigen
Alias_symbol (synonym)SCARD1
macrosialin
GP110
DKFZp686M18236
LAMP4
Other alias
HGNC (Hugo) CD68
LocusID (NCBI) 968
Atlas_Id 987
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7482806 and ends at 7485429 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CD68 (17p13.1) / CD68 (17p13.1)CD68 (17p13.1) / GM2A (5q33.1)CD68 (17p13.1) / PSAP (10q22.1)
CD68 (17p13.1) / RCC2 (1p36.13)CD68 (17p13.1) / SH3BGRL (Xq21.1)CD68 (17p13.1) / STK17B (2q32.3)
LITAF (16p13.13) / CD68 (17p13.1)PTPN4 (2q14.2) / CD68 (17p13.1)RABGAP1L (1q25.1) / CD68 (17p13.1)
TRAK2 (2q33.1) / CD68 (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Liver: Fibrolamellar carcinoma


External links

Nomenclature
HGNC (Hugo)CD68   1693
Cards
Entrez_Gene (NCBI)CD68  968  CD68 molecule
AliasesGP110; LAMP4; SCARD1
GeneCards (Weizmann)CD68
Ensembl hg19 (Hinxton)ENSG00000129226 [Gene_View]  chr17:7482806-7485429 [Contig_View]  CD68 [Vega]
Ensembl hg38 (Hinxton)ENSG00000129226 [Gene_View]  chr17:7482806-7485429 [Contig_View]  CD68 [Vega]
ICGC DataPortalENSG00000129226
TCGA cBioPortalCD68
AceView (NCBI)CD68
Genatlas (Paris)CD68
WikiGenes968
SOURCE (Princeton)CD68
Genetics Home Reference (NIH)CD68
Genomic and cartography
GoldenPath hg19 (UCSC)CD68  -     chr17:7482806-7485429 +  17p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CD68  -     17p13.1   [Description]    (hg38-Dec_2013)
EnsemblCD68 - 17p13.1 [CytoView hg19]  CD68 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBICD68 [Mapview hg19]  CD68 [Mapview hg38]
OMIM153634   
Gene and transcription
Genbank (Entrez)AK222492 AK222514 AK290238 AK298055 AK301223
RefSeq transcript (Entrez)NM_001040059 NM_001251
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_009204 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)CD68
Cluster EST : UnigeneHs.647419 [ NCBI ]
CGAP (NCI)Hs.647419
Alternative Splicing GalleryENSG00000129226
Gene ExpressionCD68 [ NCBI-GEO ]   CD68 [ EBI - ARRAY_EXPRESS ]   CD68 [ SEEK ]   CD68 [ MEM ]
Gene Expression Viewer (FireBrowse)CD68 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)968
GTEX Portal (Tissue expression)CD68
Protein : pattern, domain, 3D structure
UniProt/SwissProtP34810   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP34810  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP34810
Splice isoforms : SwissVarP34810
PhosPhoSitePlusP34810
Domaine pattern : Prosite (Expaxy)LAMP_2 (PS00311)    LAMP_3 (PS51407)   
Domains : Interpro (EBI)LAMP_CS    Lysosome-assoc_membr_glycop   
Domain families : Pfam (Sanger)Lamp (PF01299)   
Domain families : Pfam (NCBI)pfam01299   
Conserved Domain (NCBI)CD68
DMDM Disease mutations968
Blocks (Seattle)CD68
SuperfamilyP34810
Human Protein AtlasENSG00000129226
Peptide AtlasP34810
HPRD01093
IPIIPI00002252   IPI00217167   IPI00744995   
Protein Interaction databases
DIP (DOE-UCLA)P34810
IntAct (EBI)P34810
FunCoupENSG00000129226
BioGRIDCD68
STRING (EMBL)CD68
ZODIACCD68
Ontologies - Pathways
QuickGOP34810
Ontology : AmiGOlysosomal membrane  plasma membrane  endosome membrane  membrane  integral component of membrane  cellular response to organic substance  
Ontology : EGO-EBIlysosomal membrane  plasma membrane  endosome membrane  membrane  integral component of membrane  cellular response to organic substance  
Pathways : KEGGLysosome   
NDEx NetworkCD68
Atlas of Cancer Signalling NetworkCD68
Wikipedia pathwaysCD68
Orthology - Evolution
OrthoDB968
GeneTree (enSembl)ENSG00000129226
Phylogenetic Trees/Animal Genes : TreeFamCD68
HOVERGENP34810
HOGENOMP34810
Homologs : HomoloGeneCD68
Homology/Alignments : Family Browser (UCSC)CD68
Gene fusions - Rearrangements
Fusion : MitelmanCD68/PSAP [17p13.1/10q22.1]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD68 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD68
dbVarCD68
ClinVarCD68
1000_GenomesCD68 
Exome Variant ServerCD68
ExAC (Exome Aggregation Consortium)CD68 (select the gene name)
Genetic variants : HAPMAP968
Genomic Variants (DGV)CD68 [DGVbeta]
DECIPHER (Syndromes)17:7482806-7485429  ENSG00000129226
CONAN: Copy Number AnalysisCD68 
Mutations
ICGC Data PortalCD68 
TCGA Data PortalCD68 
Broad Tumor PortalCD68
OASIS PortalCD68 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD68  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD68
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD68
DgiDB (Drug Gene Interaction Database)CD68
DoCM (Curated mutations)CD68 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD68 (select a term)
intoGenCD68
Cancer3DCD68(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM153634   
Orphanet
MedgenCD68
Genetic Testing Registry CD68
NextProtP34810 [Medical]
TSGene968
GENETestsCD68
Huge Navigator CD68 [HugePedia]
snp3D : Map Gene to Disease968
BioCentury BCIQCD68
ClinGenCD68
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD968
Chemical/Pharm GKB GenePA26232
Clinical trialCD68
Miscellaneous
canSAR (ICR)CD68 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD68
EVEXCD68
GoPubMedCD68
iHOPCD68
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:59:29 CET 2017

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