CD69 (CD69 molecule)

2003-11-01  

Identity

HGNC
CD69
LOCATION
12p13.31
LOCUSID
969
ALIAS
AIM,BL-AC/P26,CLEC2C,EA1,GP32/28,MLR-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 969
MIM: 107273
HGNC: 1694
Ensembl: ENSG00000110848

Variants:

dbSNP: 969
ClinVar: 969
TCGA: ENSG00000110848
COSMIC: CD69

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110848ENST00000228434Q07108
ENSG00000110848ENST00000228434Q53ZX0
ENSG00000110848ENST00000536709B4E009

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165292659tocilizumabChemicalClinicalAnnotationassociatedPD27339827
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD27339827

References

Pubmed IDYearTitleCitations
194304802009Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.655
165254202006CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.427
239541682013Is CD69 an effective brake to control inflammatory diseases?43
195433972009Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression.40
221847222012Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages.40
185937622008Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency.37
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
214274082011CD69: an unexpected regulator of TH17 cell-driven inflammatory responses.26
226789112012Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity.19
176939772007Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers: evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells.16

Citation

Dessen P

CD69 (CD69 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/988/cd69