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CD70 (CD70 molecule)

Identity

Alias_namesCD27LG
TNFSF7
tumor necrosis factor (ligand) superfamily
Alias_symbol (synonym)CD27L
Other aliasCD27-L
TNLG8A
HGNC (Hugo) CD70
LocusID (NCBI) 970
Atlas_Id 42643
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 6585839 and ends at 6591152 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KHSRP (19p13.3) / CD70 (19p13.3)KHSRP 19p13.3 / CD70 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and Neck: Thymus: Thymoma: an overview


External links

Nomenclature
HGNC (Hugo)CD70   11937
Cards
Entrez_Gene (NCBI)CD70  970  CD70 molecule
AliasesCD27-L; CD27L; CD27LG; TNFSF7; 
TNLG8A
GeneCards (Weizmann)CD70
Ensembl hg19 (Hinxton)ENSG00000125726 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125726 [Gene_View]  chr19:6585839-6591152 [Contig_View]  CD70 [Vega]
ICGC DataPortalENSG00000125726
TCGA cBioPortalCD70
AceView (NCBI)CD70
Genatlas (Paris)CD70
WikiGenes970
SOURCE (Princeton)CD70
Genetics Home Reference (NIH)CD70
Genomic and cartography
GoldenPath hg38 (UCSC)CD70  -     chr19:6585839-6591152 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD70  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblCD70 - 19p13.3 [CytoView hg19]  CD70 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBICD70 [Mapview hg19]  CD70 [Mapview hg38]
OMIM602840   
Gene and transcription
Genbank (Entrez)AK298467 BC000725 BT007211 L08096 LN874328
RefSeq transcript (Entrez)NM_001252 NM_001330332
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD70
Cluster EST : UnigeneHs.715224 [ NCBI ]
CGAP (NCI)Hs.715224
Alternative Splicing GalleryENSG00000125726
Gene ExpressionCD70 [ NCBI-GEO ]   CD70 [ EBI - ARRAY_EXPRESS ]   CD70 [ SEEK ]   CD70 [ MEM ]
Gene Expression Viewer (FireBrowse)CD70 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)970
GTEX Portal (Tissue expression)CD70
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32970   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32970  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32970
Splice isoforms : SwissVarP32970
PhosPhoSitePlusP32970
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)    TNF_2 (PS50049)   
Domains : Interpro (EBI)TNF_CS    TNF_dom    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
Conserved Domain (NCBI)CD70
DMDM Disease mutations970
Blocks (Seattle)CD70
SuperfamilyP32970
Human Protein AtlasENSG00000125726
Peptide AtlasP32970
HPRD18515
IPIIPI00031713   IPI00909266   
Protein Interaction databases
DIP (DOE-UCLA)P32970
IntAct (EBI)P32970
FunCoupENSG00000125726
BioGRIDCD70
STRING (EMBL)CD70
ZODIACCD70
Ontologies - Pathways
QuickGOP32970
Ontology : AmiGOprotease binding  receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular space  plasma membrane  plasma membrane  integral component of plasma membrane  immune response  signal transduction  cell-cell signaling  cell proliferation  tumor necrosis factor-mediated signaling pathway  extracellular exosome  extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotease binding  receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular space  plasma membrane  plasma membrane  integral component of plasma membrane  immune response  signal transduction  cell-cell signaling  cell proliferation  tumor necrosis factor-mediated signaling pathway  extracellular exosome  extrinsic apoptotic signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkCD70
Atlas of Cancer Signalling NetworkCD70
Wikipedia pathwaysCD70
Orthology - Evolution
OrthoDB970
GeneTree (enSembl)ENSG00000125726
Phylogenetic Trees/Animal Genes : TreeFamCD70
HOVERGENP32970
HOGENOMP32970
Homologs : HomoloGeneCD70
Homology/Alignments : Family Browser (UCSC)CD70
Gene fusions - Rearrangements
Fusion : MitelmanKHSRP/CD70 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion: TCGAKHSRP 19p13.3 CD70 19p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD70 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD70
dbVarCD70
ClinVarCD70
1000_GenomesCD70 
Exome Variant ServerCD70
ExAC (Exome Aggregation Consortium)CD70 (select the gene name)
Genetic variants : HAPMAP970
Genomic Variants (DGV)CD70 [DGVbeta]
DECIPHERCD70 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD70 
Mutations
ICGC Data PortalCD70 
TCGA Data PortalCD70 
Broad Tumor PortalCD70
OASIS PortalCD70 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD70  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD70
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD70
DgiDB (Drug Gene Interaction Database)CD70
DoCM (Curated mutations)CD70 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD70 (select a term)
intoGenCD70
Cancer3DCD70(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602840   
Orphanet
MedgenCD70
Genetic Testing Registry CD70
NextProtP32970 [Medical]
TSGene970
GENETestsCD70
Target ValidationCD70
Huge Navigator CD70 [HugePedia]
snp3D : Map Gene to Disease970
BioCentury BCIQCD70
ClinGenCD70
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD970
Chemical/Pharm GKB GenePA36627
Clinical trialCD70
Miscellaneous
canSAR (ICR)CD70 (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD70
EVEXCD70
GoPubMedCD70
iHOPCD70
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:27:30 CEST 2017

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