Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CD80 (CD80 molecule)

Identity

Alias_namesCD28LG
CD28LG1
CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
CD80 molecule
Alias_symbol (synonym)B7.1
B7-1
Other aliasB7
BB1
LAB7
HGNC (Hugo) CD80
LocusID (NCBI) 941
Atlas_Id 46034
Location 3q13.33  [Link to chromosome band 3q13]
Location_base_pair Starts at 119524293 and ends at 119559634 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CD80   1700
Cards
Entrez_Gene (NCBI)CD80  941  CD80 molecule
AliasesB7; B7-1; B7.1; BB1; 
CD28LG; CD28LG1; LAB7
GeneCards (Weizmann)CD80
Ensembl hg19 (Hinxton)ENSG00000121594 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121594 [Gene_View]  ENSG00000121594 [Sequence]  chr3:119524293-119559634 [Contig_View]  CD80 [Vega]
ICGC DataPortalENSG00000121594
TCGA cBioPortalCD80
AceView (NCBI)CD80
Genatlas (Paris)CD80
WikiGenes941
SOURCE (Princeton)CD80
Genetics Home Reference (NIH)CD80
Genomic and cartography
GoldenPath hg38 (UCSC)CD80  -     chr3:119524293-119559634 -  3q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD80  -     3q13.33   [Description]    (hg19-Feb_2009)
GoldenPathCD80 - 3q13.33 [CytoView hg19]  CD80 - 3q13.33 [CytoView hg38]
ImmunoBaseENSG00000121594
Mapping of homologs : NCBICD80 [Mapview hg19]  CD80 [Mapview hg38]
OMIM112203   
Gene and transcription
Genbank (Entrez)AK292129 AY081815 AY197777 AY197778 BC042665
RefSeq transcript (Entrez)NM_005191
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD80
Cluster EST : UnigeneHs.838 [ NCBI ]
CGAP (NCI)Hs.838
Alternative Splicing GalleryENSG00000121594
Gene ExpressionCD80 [ NCBI-GEO ]   CD80 [ EBI - ARRAY_EXPRESS ]   CD80 [ SEEK ]   CD80 [ MEM ]
Gene Expression Viewer (FireBrowse)CD80 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)941
GTEX Portal (Tissue expression)CD80
Human Protein AtlasENSG00000121594-CD80 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33681   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP33681  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33681
Splice isoforms : SwissVarP33681
PhosPhoSitePlusP33681
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    CD80_IgC    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam08205    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)CD80
DMDM Disease mutations941
Blocks (Seattle)CD80
PDB (RSDB)1DR9    1I8L   
PDB Europe1DR9    1I8L   
PDB (PDBSum)1DR9    1I8L   
PDB (IMB)1DR9    1I8L   
Structural Biology KnowledgeBase1DR9    1I8L   
SCOP (Structural Classification of Proteins)1DR9    1I8L   
CATH (Classification of proteins structures)1DR9    1I8L   
SuperfamilyP33681
Human Protein Atlas [tissue]ENSG00000121594-CD80 [tissue]
Peptide AtlasP33681
HPRD00202
IPIIPI00015914   IPI00554805   IPI00554776   
Protein Interaction databases
DIP (DOE-UCLA)P33681
IntAct (EBI)P33681
FunCoupENSG00000121594
BioGRIDCD80
STRING (EMBL)CD80
ZODIACCD80
Ontologies - Pathways
QuickGOP33681
Ontology : AmiGOvirus receptor activity  protein binding  plasma membrane  immune response  signal transduction  cell surface receptor signaling pathway  external side of plasma membrane  positive regulation of signal transduction  cell surface  cell surface  coreceptor activity  integral component of membrane  cytokine-mediated signaling pathway  T cell costimulation  T cell costimulation  intracellular signal transduction  positive regulation of T cell proliferation  negative regulation of T cell proliferation  positive regulation of interleukin-2 biosynthetic process  positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process  positive regulation of T-helper 1 cell differentiation  positive regulation of transcription, DNA-templated  viral entry into host cell  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of protein kinase B signaling  cellular response to lipopolysaccharide  protein complex involved in cell adhesion  
Ontology : EGO-EBIvirus receptor activity  protein binding  plasma membrane  immune response  signal transduction  cell surface receptor signaling pathway  external side of plasma membrane  positive regulation of signal transduction  cell surface  cell surface  coreceptor activity  integral component of membrane  cytokine-mediated signaling pathway  T cell costimulation  T cell costimulation  intracellular signal transduction  positive regulation of T cell proliferation  negative regulation of T cell proliferation  positive regulation of interleukin-2 biosynthetic process  positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process  positive regulation of T-helper 1 cell differentiation  positive regulation of transcription, DNA-templated  viral entry into host cell  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of protein kinase B signaling  cellular response to lipopolysaccharide  protein complex involved in cell adhesion  
Pathways : KEGGCell adhesion molecules (CAMs)    Toll-like receptor signaling pathway    Intestinal immune network for IgA production    Type I diabetes mellitus    Autoimmune thyroid disease    Systemic lupus erythematosus    Rheumatoid arthritis    Allograft rejection    Graft-versus-host disease    Viral myocarditis   
NDEx NetworkCD80
Atlas of Cancer Signalling NetworkCD80
Wikipedia pathwaysCD80
Orthology - Evolution
OrthoDB941
GeneTree (enSembl)ENSG00000121594
Phylogenetic Trees/Animal Genes : TreeFamCD80
HOGENOMP33681
Homologs : HomoloGeneCD80
Homology/Alignments : Family Browser (UCSC)CD80
Gene fusions - Rearrangements
Fusion : QuiverCD80
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD80 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD80
dbVarCD80
ClinVarCD80
1000_GenomesCD80 
Exome Variant ServerCD80
ExAC (Exome Aggregation Consortium)ENSG00000121594
GNOMAD BrowserENSG00000121594
Varsome BrowserCD80
Genetic variants : HAPMAP941
Genomic Variants (DGV)CD80 [DGVbeta]
DECIPHERCD80 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD80 
Mutations
ICGC Data PortalCD80 
TCGA Data PortalCD80 
Broad Tumor PortalCD80
OASIS PortalCD80 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD80  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCD80
Mutations and Diseases : HGMDCD80
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD80
DgiDB (Drug Gene Interaction Database)CD80
DoCM (Curated mutations)CD80 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD80 (select a term)
intoGenCD80
Cancer3DCD80(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM112203   
Orphanet
DisGeNETCD80
MedgenCD80
Genetic Testing Registry CD80
NextProtP33681 [Medical]
TSGene941
GENETestsCD80
Target ValidationCD80
Huge Navigator CD80 [HugePedia]
snp3D : Map Gene to Disease941
BioCentury BCIQCD80
ClinGenCD80
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD941
Chemical/Pharm GKB GenePA26239
Clinical trialCD80
Miscellaneous
canSAR (ICR)CD80 (select the gene name)
DataMed IndexCD80
Probes
Litterature
PubMed206 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD80
EVEXCD80
GoPubMedCD80
iHOPCD80
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 26 18:02:26 CEST 2019
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