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CD80 (CD80 molecule)

Identity

Alias (NCBI)B7
B7-1
B7.1
BB1
CD28LG
CD28LG1
LAB7
HGNC (Hugo) CD80
HGNC Alias symbB7.1
B7-1
HGNC Alias nameB-lymphocyte activation antigen B7
HGNC Previous nameCD28LG
 CD28LG1
HGNC Previous nameCD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
 CD80 molecule
LocusID (NCBI) 941
Atlas_Id 46034
Location 3q13.33  [Link to chromosome band 3q13]
Location_base_pair Starts at 119524293 and ends at 119559614 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)CD80   1700
Cards
Entrez_Gene (NCBI)CD80    CD80 molecule
AliasesB7; B7-1; B7.1; BB1; 
CD28LG; CD28LG1; LAB7
GeneCards (Weizmann)CD80
Ensembl hg19 (Hinxton)ENSG00000121594 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121594 [Gene_View]  ENSG00000121594 [Sequence]  chr3:119524293-119559614 [Contig_View]  CD80 [Vega]
ICGC DataPortalENSG00000121594
TCGA cBioPortalCD80
AceView (NCBI)CD80
Genatlas (Paris)CD80
SOURCE (Princeton)CD80
Genetics Home Reference (NIH)CD80
Genomic and cartography
GoldenPath hg38 (UCSC)CD80  -     chr3:119524293-119559614 -  3q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD80  -     3q13.33   [Description]    (hg19-Feb_2009)
GoldenPathCD80 - 3q13.33 [CytoView hg19]  CD80 - 3q13.33 [CytoView hg38]
ImmunoBaseENSG00000121594
Genome Data Viewer NCBICD80 [Mapview hg19]  
OMIM112203   
Gene and transcription
Genbank (Entrez)AK292129 AY081815 AY197777 AY197778 BC042665
RefSeq transcript (Entrez)NM_005191
Consensus coding sequences : CCDS (NCBI)CD80
Gene ExpressionCD80 [ NCBI-GEO ]   CD80 [ EBI - ARRAY_EXPRESS ]   CD80 [ SEEK ]   CD80 [ MEM ]
Gene Expression Viewer (FireBrowse)CD80 [ Firebrowse - Broad ]
GenevisibleExpression of CD80 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)941
GTEX Portal (Tissue expression)CD80
Human Protein AtlasENSG00000121594-CD80 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33681   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP33681  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33681
PhosPhoSitePlusP33681
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    CD80_IgC    CD80_IgV    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam08205    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)CD80
PDB (RSDB)1DR9    1I8L   
PDB Europe1DR9    1I8L   
PDB (PDBSum)1DR9    1I8L   
PDB (IMB)1DR9    1I8L   
Structural Biology KnowledgeBase1DR9    1I8L   
SCOP (Structural Classification of Proteins)1DR9    1I8L   
CATH (Classification of proteins structures)1DR9    1I8L   
SuperfamilyP33681
AlphaFold pdb e-kbP33681   
Human Protein Atlas [tissue]ENSG00000121594-CD80 [tissue]
HPRD00202
Protein Interaction databases
DIP (DOE-UCLA)P33681
IntAct (EBI)P33681
BioGRIDCD80
STRING (EMBL)CD80
ZODIACCD80
Ontologies - Pathways
QuickGOP33681
Ontology : AmiGOvirus receptor activity  protein binding  plasma membrane  immune response  cell surface receptor signaling pathway  external side of plasma membrane  positive regulation of signal transduction  cell surface  coreceptor activity  integral component of membrane  T cell costimulation  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interleukin-2 production  intracellular signal transduction  positive regulation of T cell proliferation  negative regulation of T cell proliferation  positive regulation of T-helper 1 cell differentiation  positive regulation of transcription, DNA-templated  viral entry into host cell  positive regulation of peptidyl-tyrosine phosphorylation  cellular response to lipopolysaccharide  protein complex involved in cell adhesion  
Ontology : EGO-EBIvirus receptor activity  protein binding  plasma membrane  immune response  cell surface receptor signaling pathway  external side of plasma membrane  positive regulation of signal transduction  cell surface  coreceptor activity  integral component of membrane  T cell costimulation  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interleukin-2 production  intracellular signal transduction  positive regulation of T cell proliferation  negative regulation of T cell proliferation  positive regulation of T-helper 1 cell differentiation  positive regulation of transcription, DNA-templated  viral entry into host cell  positive regulation of peptidyl-tyrosine phosphorylation  cellular response to lipopolysaccharide  protein complex involved in cell adhesion  
Pathways : BIOCARTABIOCARTA_BLYMPHOCYTEPATHWAY    BIOCARTA_ASBCELLPATHWAY    BIOCARTA_CTLA4PATHWAY   
Pathways : KEGGKEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS    KEGG_CELL_ADHESION_MOLECULES_CAMS    KEGG_TOLL_LIKE_RECEPTOR_SIGNALING    KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION    KEGG_TYPE_I_DIABETES_MELLITUS    KEGG_AUTOIMMUNE_THYROID_DISEASE    KEGG_ALLOGRAFT_REJECTION    KEGG_GRAFT_VERSUS_HOST_DISEASE    KEGG_VIRAL_MYOCARDITIS   
NDEx NetworkCD80
Atlas of Cancer Signalling NetworkCD80
Wikipedia pathwaysCD80
Orthology - Evolution
OrthoDB941
GeneTree (enSembl)ENSG00000121594
Phylogenetic Trees/Animal Genes : TreeFamCD80
Homologs : HomoloGeneCD80
Homology/Alignments : Family Browser (UCSC)CD80
Gene fusions - Rearrangements
Fusion : QuiverCD80
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD80 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD80
dbVarCD80
ClinVarCD80
MonarchCD80
1000_GenomesCD80 
Exome Variant ServerCD80
GNOMAD BrowserENSG00000121594
Varsome BrowserCD80
ACMGCD80 variants
VarityP33681
Genomic Variants (DGV)CD80 [DGVbeta]
DECIPHERCD80 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD80 
Mutations
ICGC Data PortalCD80 
TCGA Data PortalCD80 
Broad Tumor PortalCD80
OASIS PortalCD80 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD80  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCD80
Mutations and Diseases : HGMDCD80
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCD80
DgiDB (Drug Gene Interaction Database)CD80
DoCM (Curated mutations)CD80
CIViC (Clinical Interpretations of Variants in Cancer)CD80
Cancer3DCD80
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM112203   
Orphanet
DisGeNETCD80
MedgenCD80
Genetic Testing Registry CD80
NextProtP33681 [Medical]
GENETestsCD80
Target ValidationCD80
Huge Navigator CD80 [HugePedia]
ClinGenCD80
Clinical trials, drugs, therapy
MyCancerGenomeCD80
Protein Interactions : CTDCD80
Pharm GKB GenePA26239
PharosP33681
Clinical trialCD80
Miscellaneous
canSAR (ICR)CD80
HarmonizomeCD80
ARCHS4CD80
DataMed IndexCD80
Probes
Litterature
PubMed226 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCD80
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:26:34 CET 2022
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