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CD81 (CD81 molecule)

Identity

Alias_namesTAPA1
CD81 antigen (target of antiproliferative antibody 1)
Alias_symbol (synonym)TAPA-1
TSPAN28
HGNC (Hugo) CD81
LocusID (NCBI) 975
Atlas_Id 991
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 2397407 and ends at 2418649 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CD81 (11p15.5) / ATPIF1 (1p35.3)CD81 (11p15.5) / AUTS2 (7q11.22)CD81 (11p15.5) / B2M (15q21.1)
CD81 (11p15.5) / PAXBP1 (21q22.11)CD81 (11p15.5) / SURF4 (9q34.2)CD81 (11p15.5) / TRA ()
MYH9 (22q12.3) / CD81 (11p15.5)CD81 11p15.5 / SURF4 9q34.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CD81   1701
LRG (Locus Reference Genomic)LRG_142
Cards
Entrez_Gene (NCBI)CD81  975  CD81 molecule
AliasesCVID6; S5.7; TAPA1; TSPAN28
GeneCards (Weizmann)CD81
Ensembl hg19 (Hinxton)ENSG00000110651 [Gene_View]  chr11:2397407-2418649 [Contig_View]  CD81 [Vega]
Ensembl hg38 (Hinxton)ENSG00000110651 [Gene_View]  chr11:2397407-2418649 [Contig_View]  CD81 [Vega]
ICGC DataPortalENSG00000110651
TCGA cBioPortalCD81
AceView (NCBI)CD81
Genatlas (Paris)CD81
WikiGenes975
SOURCE (Princeton)CD81
Genetics Home Reference (NIH)CD81
Genomic and cartography
GoldenPath hg19 (UCSC)CD81  -     chr11:2397407-2418649 +  11p15.5   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CD81  -     11p15.5   [Description]    (hg38-Dec_2013)
EnsemblCD81 - 11p15.5 [CytoView hg19]  CD81 - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBICD81 [Mapview hg19]  CD81 [Mapview hg38]
OMIM186845   613496   
Gene and transcription
Genbank (Entrez)AB209380 AI334163 BC002978 BC093047 BG397506
RefSeq transcript (Entrez)NM_001297649 NM_004356
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_023386 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)CD81
Cluster EST : UnigeneHs.54457 [ NCBI ]
CGAP (NCI)Hs.54457
Alternative Splicing GalleryENSG00000110651
Gene ExpressionCD81 [ NCBI-GEO ]   CD81 [ EBI - ARRAY_EXPRESS ]   CD81 [ SEEK ]   CD81 [ MEM ]
Gene Expression Viewer (FireBrowse)CD81 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)975
GTEX Portal (Tissue expression)CD81
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60033   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60033  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60033
Splice isoforms : SwissVarP60033
PhosPhoSitePlusP60033
Domaine pattern : Prosite (Expaxy)TM4_1 (PS00421)   
Domains : Interpro (EBI)CD81_LEL    Tetraspanin    Tetraspanin/Peripherin    Tetraspanin_CS    Tetraspanin_EC2   
Domain families : Pfam (Sanger)Tetraspannin (PF00335)   
Domain families : Pfam (NCBI)pfam00335   
Conserved Domain (NCBI)CD81
DMDM Disease mutations975
Blocks (Seattle)CD81
PDB (SRS)1G8Q    1IV5    2AVZ    3X0E    4BKH    5DFV    5DFW   
PDB (PDBSum)1G8Q    1IV5    2AVZ    3X0E    4BKH    5DFV    5DFW   
PDB (IMB)1G8Q    1IV5    2AVZ    3X0E    4BKH    5DFV    5DFW   
PDB (RSDB)1G8Q    1IV5    2AVZ    3X0E    4BKH    5DFV    5DFW   
Structural Biology KnowledgeBase1G8Q    1IV5    2AVZ    3X0E    4BKH    5DFV    5DFW   
SCOP (Structural Classification of Proteins)1G8Q    1IV5    2AVZ    3X0E    4BKH    5DFV    5DFW   
CATH (Classification of proteins structures)1G8Q    1IV5    2AVZ    3X0E    4BKH    5DFV    5DFW   
SuperfamilyP60033
Human Protein AtlasENSG00000110651
Peptide AtlasP60033
HPRD08924
IPIIPI00000190   IPI00555750   IPI00657752   IPI00975882   IPI00980190   IPI00977561   IPI00983214   IPI00979139   IPI00979839   IPI00982190   IPI00981672   IPI00978459   
Protein Interaction databases
DIP (DOE-UCLA)P60033
IntAct (EBI)P60033
FunCoupENSG00000110651
BioGRIDCD81
STRING (EMBL)CD81
ZODIACCD81
Ontologies - Pathways
QuickGOP60033
Ontology : AmiGOactivation of MAPK activity  immunological synapse  protein binding  plasma membrane  integral component of plasma membrane  focal adhesion  cell surface receptor signaling pathway  protein localization  cell proliferation  positive regulation of cell proliferation  response to wounding  membrane  apical plasma membrane  MHC class II protein complex binding  positive regulation of B cell proliferation  receptor internalization  regulation of protein stability  vesicle  regulation of growth  positive regulation of 1-phosphatidylinositol 4-kinase activity  positive regulation of transcription from RNA polymerase II promoter  viral entry into host cell  receptor-mediated virion attachment to host cell  positive regulation of peptidyl-tyrosine phosphorylation  regulation of immune response  protein localization to lysosome  extracellular exosome  cellular response to low-density lipoprotein particle stimulus  positive regulation of protein catabolic process in the vacuole  transferrin receptor binding  regulation of cell motility  
Ontology : EGO-EBIactivation of MAPK activity  immunological synapse  protein binding  plasma membrane  integral component of plasma membrane  focal adhesion  cell surface receptor signaling pathway  protein localization  cell proliferation  positive regulation of cell proliferation  response to wounding  membrane  apical plasma membrane  MHC class II protein complex binding  positive regulation of B cell proliferation  receptor internalization  regulation of protein stability  vesicle  regulation of growth  positive regulation of 1-phosphatidylinositol 4-kinase activity  positive regulation of transcription from RNA polymerase II promoter  viral entry into host cell  receptor-mediated virion attachment to host cell  positive regulation of peptidyl-tyrosine phosphorylation  regulation of immune response  protein localization to lysosome  extracellular exosome  cellular response to low-density lipoprotein particle stimulus  positive regulation of protein catabolic process in the vacuole  transferrin receptor binding  regulation of cell motility  
Pathways : KEGGB cell receptor signaling pathway    Malaria    Hepatitis C   
NDEx NetworkCD81
Atlas of Cancer Signalling NetworkCD81
Wikipedia pathwaysCD81
Orthology - Evolution
OrthoDB975
GeneTree (enSembl)ENSG00000110651
Phylogenetic Trees/Animal Genes : TreeFamCD81
HOVERGENP60033
HOGENOMP60033
Homologs : HomoloGeneCD81
Homology/Alignments : Family Browser (UCSC)CD81
Gene fusions - Rearrangements
Fusion : MitelmanCD81/SURF4 [11p15.5/9q34.2]  
Fusion: TCGACD81 11p15.5 SURF4 9q34.2 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD81 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD81
dbVarCD81
ClinVarCD81
1000_GenomesCD81 
Exome Variant ServerCD81
ExAC (Exome Aggregation Consortium)CD81 (select the gene name)
Genetic variants : HAPMAP975
Genomic Variants (DGV)CD81 [DGVbeta]
DECIPHER (Syndromes)11:2397407-2418649  ENSG00000110651
CONAN: Copy Number AnalysisCD81 
Mutations
ICGC Data PortalCD81 
TCGA Data PortalCD81 
Broad Tumor PortalCD81
OASIS PortalCD81 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD81  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD81
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch CD81
DgiDB (Drug Gene Interaction Database)CD81
DoCM (Curated mutations)CD81 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD81 (select a term)
intoGenCD81
Cancer3DCD81(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186845    613496   
Orphanet3469   
MedgenCD81
Genetic Testing Registry CD81
NextProtP60033 [Medical]
TSGene975
GENETestsCD81
Huge Navigator CD81 [HugePedia]
snp3D : Map Gene to Disease975
BioCentury BCIQCD81
ClinGenCD81
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD975
Chemical/Pharm GKB GenePA26240
Clinical trialCD81
Miscellaneous
canSAR (ICR)CD81 (select the gene name)
Probes
Litterature
PubMed237 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD81
EVEXCD81
GoPubMedCD81
iHOPCD81
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:33:25 CET 2016

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