CD84 (CD84 molecule)

2016-10-01  

Identity

HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
LY9B,SLAMF5,hCD84,mCD84
FUSION GENES

Other Information

Locus ID:

NCBI: 8832
MIM: 604513
HGNC: 1704
Ensembl: ENSG00000066294

Variants:

dbSNP: 8832
ClinVar: 8832
TCGA: ENSG00000066294
COSMIC: CD84

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000066294ENST00000311224Q9UIB8
ENSG00000066294ENST00000368048Q9UIB8
ENSG00000066294ENST00000368051Q9UIB8
ENSG00000066294ENST00000368054Q9UIB8
ENSG00000066294ENST00000534968Q9UIB8

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD27564082
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD27564082
PA449515etanerceptChemicalClinicalAnnotationassociatedPD27564082

References

Pubmed IDYearTitleCitations
235553002013Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.54
175633752007Structure of CD84 provides insight into SLAM family function.31
129283972003Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation.17
220682342011CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells.12
182433212008The leukocyte receptor CD84 inhibits Fc epsilon RI-mediated signaling through homophilic interaction in transfected RBL-2H3 cells.9
234354172014CD84 is a survival receptor for CLL cells.8
274525242017CD84 mediates CLL-microenvironment interactions.6
246350442014CD84 is markedly up-regulated in Kawasaki disease arteriopathy.3
294345922018Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8.2
305141202019The temporal pattern of immune and inflammatory proteins prior to a recurrent coronary event in post-acute coronary syndrome patients.1

Citation

Dessen P

CD84 (CD84 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56016/cd84