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CD86 (CD86 molecule)

Identity

Other namesB7-2
B7.2
B70
CD28LG2
LAB72
HGNC (Hugo) CD86
LocusID (NCBI) 942
Atlas_Id 992
Location 3q13.33
Location_base_pair Starts at 121774209 and ends at 121839988 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CD86   1705
Cards
Entrez_Gene (NCBI)CD86  942  CD86 molecule
GeneCards (Weizmann)CD86
Ensembl hg19 (Hinxton)ENSG00000114013 [Gene_View]  chr3:121774209-121839988 [Contig_View]  CD86 [Vega]
Ensembl hg38 (Hinxton)ENSG00000114013 [Gene_View]  chr3:121774209-121839988 [Contig_View]  CD86 [Vega]
ICGC DataPortalENSG00000114013
TCGA cBioPortalCD86
AceView (NCBI)CD86
Genatlas (Paris)CD86
WikiGenes942
SOURCE (Princeton)CD86
Genomic and cartography
GoldenPath hg19 (UCSC)CD86  -     chr3:121774209-121839988 +  3q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CD86  -     3q13.33   [Description]    (hg38-Dec_2013)
EnsemblCD86 - 3q13.33 [CytoView hg19]  CD86 - 3q13.33 [CytoView hg38]
Mapping of homologs : NCBICD86 [Mapview hg19]  CD86 [Mapview hg38]
OMIM601020   
Gene and transcription
Genbank (Entrez)AK291497 AK294663 AK301237 AK313103 AK316203
RefSeq transcript (Entrez)NM_001206924 NM_001206925 NM_006889 NM_175862 NM_176892
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_029928 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)CD86
Cluster EST : UnigeneHs.171182 [ NCBI ]
CGAP (NCI)Hs.171182
Alternative Splicing : Fast-db (Paris)GSHG0021087
Alternative Splicing GalleryENSG00000114013
Gene ExpressionCD86 [ NCBI-GEO ]     CD86 [ SEEK ]   CD86 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42081 (Uniprot)
NextProtP42081  [Medical]  [Publications]
With graphics : InterProP42081
Splice isoforms : SwissVarP42081 (Swissvar)
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_V-set   
Related proteins : CluSTrP42081
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IGv (SM00406)  
DMDM Disease mutations942
Blocks (Seattle)P42081
PDB (SRS)1I85    1NCN   
PDB (PDBSum)1I85    1NCN   
PDB (IMB)1I85    1NCN   
PDB (RSDB)1I85    1NCN   
Human Protein AtlasENSG00000114013
Peptide AtlasP42081
HPRD03011
IPIIPI00290621   IPI00473032   IPI00947322   IPI00397658   IPI00947161   IPI00922788   IPI00947013   
Protein Interaction databases
DIP (DOE-UCLA)P42081
IntAct (EBI)P42081
FunCoupENSG00000114013
BioGRIDCD86
IntegromeDBCD86
STRING (EMBL)CD86
Ontologies - Pathways
QuickGOP42081
Ontology : AmiGOresponse to yeast  toll-like receptor signaling pathway  T cell proliferation involved in immune response  negative regulation of T cell anergy  receptor activity  receptor binding  protein binding  plasma membrane  immune response  epidermal growth factor receptor signaling pathway  cell-cell signaling  aging  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  external side of plasma membrane  cell surface  coreceptor activity  integral component of membrane  viral process  T cell costimulation  response to interferon-gamma  Fc-epsilon receptor signaling pathway  positive regulation of activated T cell proliferation  T cell activation  B cell activation  response to drug  myeloid dendritic cell differentiation  positive regulation of lymphotoxin A biosynthetic process  intracellular membrane-bounded organelle  positive regulation of interleukin-2 biosynthetic process  innate immune response  positive regulation of interleukin-4 biosynthetic process  positive regulation of T-helper 2 cell differentiation  positive regulation of transcription, DNA-templated  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  defense response to virus  extracellular exosome  cellular response to lipopolysaccharide  cellular response to metal ion  cellular response to cytokine stimulus  
Ontology : EGO-EBIresponse to yeast  toll-like receptor signaling pathway  T cell proliferation involved in immune response  negative regulation of T cell anergy  receptor activity  receptor binding  protein binding  plasma membrane  immune response  epidermal growth factor receptor signaling pathway  cell-cell signaling  aging  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  external side of plasma membrane  cell surface  coreceptor activity  integral component of membrane  viral process  T cell costimulation  response to interferon-gamma  Fc-epsilon receptor signaling pathway  positive regulation of activated T cell proliferation  T cell activation  B cell activation  response to drug  myeloid dendritic cell differentiation  positive regulation of lymphotoxin A biosynthetic process  intracellular membrane-bounded organelle  positive regulation of interleukin-2 biosynthetic process  innate immune response  positive regulation of interleukin-4 biosynthetic process  positive regulation of T-helper 2 cell differentiation  positive regulation of transcription, DNA-templated  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  defense response to virus  extracellular exosome  cellular response to lipopolysaccharide  cellular response to metal ion  cellular response to cytokine stimulus  
Pathways : BIOCARTAThe Co-Stimulatory Signal During T-cell Activation [Genes]    Th1/Th2 Differentiation [Genes]   
Pathways : KEGGCell adhesion molecules (CAMs)    Toll-like receptor signaling pathway    Intestinal immune network for IgA production    Type I diabetes mellitus    Transcriptional misregulation in cancer    Autoimmune thyroid disease    Systemic lupus erythematosus    Rheumatoid arthritis    Allograft rejection    Graft-versus-host disease    Viral myocarditis   
Protein Interaction DatabaseCD86
DoCM (Curated mutations)CD86
Wikipedia pathwaysCD86
Gene fusion - Rearrangements
Gene fusion: TCGARAD18 CD86  KPNA1 CD86  
Polymorphisms : SNP, variants
NCBI Variation ViewerCD86 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD86
dbVarCD86
ClinVarCD86
1000_GenomesCD86 
Exome Variant ServerCD86
SNP (GeneSNP Utah)CD86
SNP : HGBaseCD86
Genetic variants : HAPMAPCD86
Genomic Variants (DGV)CD86 [DGVbeta]
Mutations
ICGC Data PortalCD86 
TCGA Data PortalCD86 
Tumor PortalCD86
Somatic Mutations in Cancer : COSMICCD86 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:121774209-121839988
CONAN: Copy Number AnalysisCD86 
Mutations and Diseases : HGMDCD86
OMIM601020   
MedgenCD86
NextProtP42081 [Medical]
GENETestsCD86
Disease Genetic AssociationCD86
Huge Navigator CD86 [HugePedia]  CD86 [HugeCancerGEM]
snp3D : Map Gene to Disease942
DGIdb (Drug Gene Interaction db)CD86
BioCentury BCIQCD86
General knowledge
Homologs : HomoloGeneCD86
Homology/Alignments : Family Browser (UCSC)CD86
Phylogenetic Trees/Animal Genes : TreeFamCD86
Chemical/Protein Interactions : CTD942
Chemical/Pharm GKB GenePA26243
Clinical trialCD86
Cancer Resource (Charite)ENSG00000114013
Other databases
Probes
Litterature
PubMed194 Pubmed reference(s) in Entrez
CoreMineCD86
GoPubMedCD86
iHOPCD86
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 11:20:23 CEST 2015

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