Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CD8A (CD8a molecule)

Identity

Alias_namesCD8
CD8 antigen, alpha polypeptide (p32)
T-cell surface glycoprotein CD8 alpha chain
Other aliasLeu2
MAL
p32
HGNC (Hugo) CD8A
LocusID (NCBI) 925
Atlas_Id 993
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 86784605 and ends at 86808396 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CD8A (2p11.2) / RBM15 (1p13.3)RBM15 (1p13.3) / CD8A (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hepatosplenic T-cell lymphoma (HSTCL)


External links

Nomenclature
HGNC (Hugo)CD8A   1706
LRG (Locus Reference Genomic)LRG_44
Cards
Entrez_Gene (NCBI)CD8A  925  CD8a molecule
AliasesCD8; Leu2; MAL; p32
GeneCards (Weizmann)CD8A
Ensembl hg19 (Hinxton)ENSG00000153563 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153563 [Gene_View]  chr2:86784605-86808396 [Contig_View]  CD8A [Vega]
ICGC DataPortalENSG00000153563
TCGA cBioPortalCD8A
AceView (NCBI)CD8A
Genatlas (Paris)CD8A
WikiGenes925
SOURCE (Princeton)CD8A
Genetics Home Reference (NIH)CD8A
Genomic and cartography
GoldenPath hg38 (UCSC)CD8A  -     chr2:86784605-86808396 -  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD8A  -     2p11.2   [Description]    (hg19-Feb_2009)
EnsemblCD8A - 2p11.2 [CytoView hg19]  CD8A - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBICD8A [Mapview hg19]  CD8A [Mapview hg38]
OMIM186910   608957   
Gene and transcription
Genbank (Entrez)AA668685 AK097942 AK124156 AK300089 AY039664
RefSeq transcript (Entrez)NM_001145873 NM_001768 NM_171827
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD8A
Cluster EST : UnigeneHs.85258 [ NCBI ]
CGAP (NCI)Hs.85258
Alternative Splicing GalleryENSG00000153563
Gene ExpressionCD8A [ NCBI-GEO ]   CD8A [ EBI - ARRAY_EXPRESS ]   CD8A [ SEEK ]   CD8A [ MEM ]
Gene Expression Viewer (FireBrowse)CD8A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)925
GTEX Portal (Tissue expression)CD8A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01732   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01732  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01732
Splice isoforms : SwissVarP01732
PhosPhoSitePlusP01732
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD8_asu    Ig-like_dom    Ig-like_fold    Ig_sub    Ig_V-set   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGv (SM00406)  
Conserved Domain (NCBI)CD8A
DMDM Disease mutations925
Blocks (Seattle)CD8A
PDB (SRS)1AKJ    1CD8    1Q69    2HP4    3QZW   
PDB (PDBSum)1AKJ    1CD8    1Q69    2HP4    3QZW   
PDB (IMB)1AKJ    1CD8    1Q69    2HP4    3QZW   
PDB (RSDB)1AKJ    1CD8    1Q69    2HP4    3QZW   
Structural Biology KnowledgeBase1AKJ    1CD8    1Q69    2HP4    3QZW   
SCOP (Structural Classification of Proteins)1AKJ    1CD8    1Q69    2HP4    3QZW   
CATH (Classification of proteins structures)1AKJ    1CD8    1Q69    2HP4    3QZW   
SuperfamilyP01732
Human Protein AtlasENSG00000153563
Peptide AtlasP01732
HPRD01737
IPIIPI00941413   IPI00016781   IPI00916748   IPI00438278   IPI00917366   
Protein Interaction databases
DIP (DOE-UCLA)P01732
IntAct (EBI)P01732
FunCoupENSG00000153563
BioGRIDCD8A
STRING (EMBL)CD8A
ZODIACCD8A
Ontologies - Pathways
QuickGOP01732
Ontology : AmiGOT cell mediated immunity  protein binding  extracellular region  plasma membrane  integral component of plasma membrane  immune response  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  external side of plasma membrane  coreceptor activity  antigen processing and presentation  protein kinase binding  T cell receptor complex  T cell activation  MHC class I protein binding  protein homodimerization activity  cytotoxic T cell differentiation  regulation of immune response  positive regulation of calcium-mediated signaling  defense response to virus  
Ontology : EGO-EBIT cell mediated immunity  protein binding  extracellular region  plasma membrane  integral component of plasma membrane  immune response  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  external side of plasma membrane  coreceptor activity  antigen processing and presentation  protein kinase binding  T cell receptor complex  T cell activation  MHC class I protein binding  protein homodimerization activity  cytotoxic T cell differentiation  regulation of immune response  positive regulation of calcium-mediated signaling  defense response to virus  
Pathways : BIOCARTAT Cytotoxic Cell Surface Molecules [Genes]    IL 17 Signaling Pathway [Genes]    Regulation of hematopoiesis by cytokines [Genes]   
Pathways : KEGGCell adhesion molecules (CAMs)    Antigen processing and presentation    Hematopoietic cell lineage    T cell receptor signaling pathway    Primary immunodeficiency   
NDEx NetworkCD8A
Atlas of Cancer Signalling NetworkCD8A
Wikipedia pathwaysCD8A
Orthology - Evolution
OrthoDB925
GeneTree (enSembl)ENSG00000153563
Phylogenetic Trees/Animal Genes : TreeFamCD8A
HOVERGENP01732
HOGENOMP01732
Homologs : HomoloGeneCD8A
Homology/Alignments : Family Browser (UCSC)CD8A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD8A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD8A
dbVarCD8A
ClinVarCD8A
1000_GenomesCD8A 
Exome Variant ServerCD8A
ExAC (Exome Aggregation Consortium)CD8A (select the gene name)
Genetic variants : HAPMAP925
Genomic Variants (DGV)CD8A [DGVbeta]
DECIPHERCD8A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD8A 
Mutations
ICGC Data PortalCD8A 
TCGA Data PortalCD8A 
Broad Tumor PortalCD8A
OASIS PortalCD8A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD8A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD8A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch CD8A
DgiDB (Drug Gene Interaction Database)CD8A
DoCM (Curated mutations)CD8A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD8A (select a term)
intoGenCD8A
Cancer3DCD8A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186910    608957   
Orphanet17817   
MedgenCD8A
Genetic Testing Registry CD8A
NextProtP01732 [Medical]
TSGene925
GENETestsCD8A
Target ValidationCD8A
Huge Navigator CD8A [HugePedia]
snp3D : Map Gene to Disease925
BioCentury BCIQCD8A
ClinGenCD8A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD925
Chemical/Pharm GKB GenePA26244
Clinical trialCD8A
Miscellaneous
canSAR (ICR)CD8A (select the gene name)
Probes
Litterature
PubMed125 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD8A
EVEXCD8A
GoPubMedCD8A
iHOPCD8A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:27:32 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.