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CD8B (CD8b molecule)

Identity

Alias_namesCD8B1
CD8 antigen
Other aliasLEU2
LY3
LYT3
P37
HGNC (Hugo) CD8B
LocusID (NCBI) 926
Atlas_Id 994
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 86815337 and ends at 86861924 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
USP39 (2p11.2) / CD8B (2p11.2)USP39 2p11.2 / CD8B 2p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  USP39/CD8B (2p11)


External links

Nomenclature
HGNC (Hugo)CD8B   1707
Cards
Entrez_Gene (NCBI)CD8B  926  CD8b molecule
AliasesCD8B1; LEU2; LY3; LYT3; 
P37
GeneCards (Weizmann)CD8B
Ensembl hg19 (Hinxton)ENSG00000172116 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172116 [Gene_View]  ENSG00000172116 [Sequence]  chr2:86815337-86861924 [Contig_View]  CD8B [Vega]
ICGC DataPortalENSG00000172116
TCGA cBioPortalCD8B
AceView (NCBI)CD8B
Genatlas (Paris)CD8B
WikiGenes926
SOURCE (Princeton)CD8B
Genetics Home Reference (NIH)CD8B
Genomic and cartography
GoldenPath hg38 (UCSC)CD8B  -     chr2:86815337-86861924 -  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD8B  -     2p11.2   [Description]    (hg19-Feb_2009)
EnsemblCD8B - 2p11.2 [CytoView hg19]  CD8B - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBICD8B [Mapview hg19]  CD8B [Mapview hg38]
OMIM186730   
Gene and transcription
Genbank (Entrez)AK303360 AK303595 AW296309 AW611750 BC100911
RefSeq transcript (Entrez)NM_001178100 NM_004931 NM_172099 NM_172101 NM_172102 NM_172213
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD8B
Cluster EST : UnigeneHs.405667 [ NCBI ]
CGAP (NCI)Hs.405667
Alternative Splicing GalleryENSG00000172116
Gene ExpressionCD8B [ NCBI-GEO ]   CD8B [ EBI - ARRAY_EXPRESS ]   CD8B [ SEEK ]   CD8B [ MEM ]
Gene Expression Viewer (FireBrowse)CD8B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)926
GTEX Portal (Tissue expression)CD8B
Human Protein AtlasENSG00000172116-CD8B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10966   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10966  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10966
Splice isoforms : SwissVarP10966
PhosPhoSitePlusP10966
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGv (SM00406)  
Conserved Domain (NCBI)CD8B
DMDM Disease mutations926
Blocks (Seattle)CD8B
SuperfamilyP10966
Human Protein Atlas [tissue]ENSG00000172116-CD8B [tissue]
Peptide AtlasP10966
HPRD01725
IPIIPI00023641   IPI00218643   IPI00218644   IPI00218645   IPI00333756   IPI00969593   IPI00969609   IPI00969417   IPI00942104   IPI00939628   IPI01014879   IPI00871295   
Protein Interaction databases
DIP (DOE-UCLA)P10966
IntAct (EBI)P10966
FunCoupENSG00000172116
BioGRIDCD8B
STRING (EMBL)CD8B
ZODIACCD8B
Ontologies - Pathways
QuickGOP10966
Ontology : AmiGOadaptive immune response  protein binding  extracellular region  plasma membrane  integral component of plasma membrane  immune response  transmembrane receptor protein tyrosine kinase signaling pathway  coreceptor activity  early endosome membrane  T cell receptor complex  T cell activation  MHC class I protein binding  regulation of defense response to virus by virus  regulation of immune response  
Ontology : EGO-EBIadaptive immune response  protein binding  extracellular region  plasma membrane  integral component of plasma membrane  immune response  transmembrane receptor protein tyrosine kinase signaling pathway  coreceptor activity  early endosome membrane  T cell receptor complex  T cell activation  MHC class I protein binding  regulation of defense response to virus by virus  regulation of immune response  
Pathways : KEGGCell adhesion molecules (CAMs)    Antigen processing and presentation    Hematopoietic cell lineage    T cell receptor signaling pathway    Primary immunodeficiency   
NDEx NetworkCD8B
Atlas of Cancer Signalling NetworkCD8B
Wikipedia pathwaysCD8B
Orthology - Evolution
OrthoDB926
GeneTree (enSembl)ENSG00000172116
Phylogenetic Trees/Animal Genes : TreeFamCD8B
HOVERGENP10966
HOGENOMP10966
Homologs : HomoloGeneCD8B
Homology/Alignments : Family Browser (UCSC)CD8B
Gene fusions - Rearrangements
Fusion : MitelmanUSP39/CD8B [2p11.2/2p11.2]  [t(2;2)(p11;p11)]  
Fusion PortalUSP39 2p11.2 CD8B 2p11.2 HNSC
Fusion : QuiverCD8B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD8B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD8B
dbVarCD8B
ClinVarCD8B
1000_GenomesCD8B 
Exome Variant ServerCD8B
ExAC (Exome Aggregation Consortium)ENSG00000172116
GNOMAD BrowserENSG00000172116
Varsome BrowserCD8B
Genetic variants : HAPMAP926
Genomic Variants (DGV)CD8B [DGVbeta]
DECIPHERCD8B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD8B 
Mutations
ICGC Data PortalCD8B 
TCGA Data PortalCD8B 
Broad Tumor PortalCD8B
OASIS PortalCD8B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD8B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD8B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD8B
DgiDB (Drug Gene Interaction Database)CD8B
DoCM (Curated mutations)CD8B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD8B (select a term)
intoGenCD8B
Cancer3DCD8B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186730   
Orphanet
DisGeNETCD8B
MedgenCD8B
Genetic Testing Registry CD8B
NextProtP10966 [Medical]
TSGene926
GENETestsCD8B
Target ValidationCD8B
Huge Navigator CD8B [HugePedia]
snp3D : Map Gene to Disease926
BioCentury BCIQCD8B
ClinGenCD8B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD926
Chemical/Pharm GKB GenePA26245
Clinical trialCD8B
Miscellaneous
canSAR (ICR)CD8B (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD8B
EVEXCD8B
GoPubMedCD8B
iHOPCD8B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:56:58 CET 2018

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