CDC14A (cell division cycle 14A)

2003-06-01  

Identity

HGNC
LOCATION
1p21.2
LOCUSID
ALIAS
DFNB105,DFNB32,DFNB35,cdc14,hCDC14
FUSION GENES

Other Information

Locus ID:

NCBI: 8556
MIM: 603504
HGNC: 1718
Ensembl: ENSG00000079335

Variants:

dbSNP: 8556
ClinVar: 8556
TCGA: ENSG00000079335
COSMIC: CDC14A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079335ENST00000336454Q9UNH5
ENSG00000079335ENST00000361544Q9UNH5
ENSG00000079335ENST00000370124Q9UNH5
ENSG00000079335ENST00000455467C9JSP6
ENSG00000079335ENST00000635056A0A0U1RQX7
ENSG00000079335ENST00000644676A0A2R8YDJ8
ENSG00000079335ENST00000644813Q9UNH5
ENSG00000079335ENST00000644844A0A2R8YEK7
ENSG00000079335ENST00000646563A0A2R8Y3W8
ENSG00000079335ENST00000646665A0A2R8YGM0
ENSG00000079335ENST00000647005A0A2R8Y6L0
ENSG00000079335ENST00000647203A0A2R8Y5L8

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphaseREACTOMER-HSA-176407

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
119014242002Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.59
121340692002Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase.53
204794642010Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair.45
167604642006Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy.38
182352252008A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3.23
159116252005Functional homology among human and fission yeast Cdc14 phosphatases.19
227840932012Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.18
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.16
173718732007Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells.15

Citation

Dessen P

CDC14A (cell division cycle 14A)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40000/cdc14a