CDC14B (cell division cycle 14B)

2003-06-01  

Identity

HGNC
LOCATION
9q22.33
LOCUSID
ALIAS
CDC14B3,Cdc14B1,Cdc14B2,hCDC14B
FUSION GENES

Other Information

Locus ID:

NCBI: 8555
MIM: 603505
HGNC: 1719
Ensembl: ENSG00000081377

Variants:

dbSNP: 8555
ClinVar: 8555
TCGA: ENSG00000081377
COSMIC: CDC14B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000081377ENST00000375240O60729
ENSG00000081377ENST00000375241O60729
ENSG00000081377ENST00000375242O60729
ENSG00000081377ENST00000412285H7C3U8
ENSG00000081377ENST00000415608Q5JU07
ENSG00000081377ENST00000452280H0Y577
ENSG00000081377ENST00000463569O60729
ENSG00000081377ENST00000474602O60729

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186625412008The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.180
204794642010Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair.45
158998582005The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules.36
184180582008The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells.36
184581572008Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication.23
159116252005Functional homology among human and fission yeast Cdc14 phosphatases.19
213795802011Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity.19
227840932012Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.18
153621132004Visualization of a highly organized intranuclear network of filaments in living mammalian cells.15
260237732015Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis.11

Citation

Dessen P

CDC14B (cell division cycle 14B)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40001/cdc14b