Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CDC25C (cell division cycle 25C)

Identity

Alias (NCBI)CDC25
PPP1R60
HGNC (Hugo) CDC25C
HGNC Alias symbPPP1R60
HGNC Alias nameprotein phosphatase 1, regulatory subunit 60
 CDC25 homolog C (S. pombe)
HGNC Previous nameCDC25
LocusID (NCBI) 995
Atlas_Id 40006
Location 5q31.2  [Link to chromosome band 5q31]
Location_base_pair Starts at 138285265 and ends at 138331877 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM13B (5q31.2) / CDC25C (5q31.2)LAT2 (7q11.23) / CDC25C (5q31.2)PAIP2 (5q31.2) / CDC25C (5q31.2)
FAM13B 5q31.2 / CDC25C 5q31.2PAIP2 5q31.2 / CDC25C 5q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CDC25C   1727
Cards
Entrez_Gene (NCBI)CDC25C    cell division cycle 25C
AliasesCDC25; PPP1R60
GeneCards (Weizmann)CDC25C
Ensembl hg19 (Hinxton)ENSG00000158402 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158402 [Gene_View]  ENSG00000158402 [Sequence]  chr5:138285265-138331877 [Contig_View]  CDC25C [Vega]
ICGC DataPortalENSG00000158402
TCGA cBioPortalCDC25C
AceView (NCBI)CDC25C
Genatlas (Paris)CDC25C
SOURCE (Princeton)CDC25C
Genetics Home Reference (NIH)CDC25C
Genomic and cartography
GoldenPath hg38 (UCSC)CDC25C  -     chr5:138285265-138331877 -  5q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDC25C  -     5q31.2   [Description]    (hg19-Feb_2009)
GoldenPathCDC25C - 5q31.2 [CytoView hg19]  CDC25C - 5q31.2 [CytoView hg38]
ImmunoBaseENSG00000158402
Genome Data Viewer NCBICDC25C [Mapview hg19]  
OMIM157680   
Gene and transcription
Genbank (Entrez)AF086323 AF277723 AF277724 AF277725 AF277726
RefSeq transcript (Entrez)NM_001287582 NM_001287583 NM_001318098 NM_001364026 NM_001364027 NM_001364028 NM_001790 NM_022809
Consensus coding sequences : CCDS (NCBI)CDC25C
Gene ExpressionCDC25C [ NCBI-GEO ]   CDC25C [ EBI - ARRAY_EXPRESS ]   CDC25C [ SEEK ]   CDC25C [ MEM ]
Gene Expression Viewer (FireBrowse)CDC25C [ Firebrowse - Broad ]
GenevisibleExpression of CDC25C in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)995
GTEX Portal (Tissue expression)CDC25C
Human Protein AtlasENSG00000158402-CDC25C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30307   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30307  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30307
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP30307
Domaine pattern : Prosite (Expaxy)RHODANESE_3 (PS50206)   
Domains : Interpro (EBI)MPI_Phosphatase    Rhodanese-like_dom    Rhodanese-like_dom_sf   
Domain families : Pfam (Sanger)M-inducer_phosp (PF06617)    Rhodanese (PF00581)   
Domain families : Pfam (NCBI)pfam06617    pfam00581   
Domain families : Smart (EMBL)RHOD (SM00450)  
Conserved Domain (NCBI)CDC25C
PDB (RSDB)2OJX    3BZI    3OP3    5M35    5M36    5M37   
PDB Europe2OJX    3BZI    3OP3    5M35    5M36    5M37   
PDB (PDBSum)2OJX    3BZI    3OP3    5M35    5M36    5M37   
PDB (IMB)2OJX    3BZI    3OP3    5M35    5M36    5M37   
Structural Biology KnowledgeBase2OJX    3BZI    3OP3    5M35    5M36    5M37   
SCOP (Structural Classification of Proteins)2OJX    3BZI    3OP3    5M35    5M36    5M37   
CATH (Classification of proteins structures)2OJX    3BZI    3OP3    5M35    5M36    5M37   
SuperfamilyP30307
AlphaFold pdb e-kbP30307   
Human Protein Atlas [tissue]ENSG00000158402-CDC25C [tissue]
HPRD01146
Protein Interaction databases
DIP (DOE-UCLA)P30307
IntAct (EBI)P30307
BioGRIDCDC25C
STRING (EMBL)CDC25C
ZODIACCDC25C
Ontologies - Pathways
QuickGOP30307
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  mitochondrial intermembrane space  cytosol  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  regulation of mitotic nuclear division  spermatogenesis  cell population proliferation  positive regulation of G2/M transition of mitotic cell cycle  nuclear speck  protein kinase binding  peptidyl-tyrosine dephosphorylation  perinuclear region of cytoplasm  WW domain binding  cell division  positive regulation of G2/MI transition of meiotic cell cycle  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  mitochondrial intermembrane space  cytosol  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  regulation of mitotic nuclear division  spermatogenesis  cell population proliferation  positive regulation of G2/M transition of mitotic cell cycle  nuclear speck  protein kinase binding  peptidyl-tyrosine dephosphorylation  perinuclear region of cytoplasm  WW domain binding  cell division  positive regulation of G2/MI transition of meiotic cell cycle  
Pathways : BIOCARTAHow Progesterone Initiates the Oocyte Maturation [Genes]    cdc25 and chk1 Regulatory Pathway in response to DNA damage [Genes]    Activation of Src by Protein-tyrosine phosphatase alpha [Genes]    Cell Cycle: G2/M Checkpoint [Genes]    Regulation of cell cycle progression by Plk3 [Genes]    Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle [Genes]    RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage [Genes]   
Pathways : KEGGCell cycle    Oocyte meiosis    Progesterone-mediated oocyte maturation    MicroRNAs in cancer   
NDEx NetworkCDC25C
Atlas of Cancer Signalling NetworkCDC25C
Wikipedia pathwaysCDC25C
Orthology - Evolution
OrthoDB995
GeneTree (enSembl)ENSG00000158402
Phylogenetic Trees/Animal Genes : TreeFamCDC25C
Homologs : HomoloGeneCDC25C
Homology/Alignments : Family Browser (UCSC)CDC25C
Gene fusions - Rearrangements
Fusion : MitelmanFAM13B/CDC25C [5q31.2/5q31.2]  
Fusion : MitelmanPAIP2/CDC25C [5q31.2/5q31.2]  
Fusion : QuiverCDC25C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDC25C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDC25C
dbVarCDC25C
ClinVarCDC25C
MonarchCDC25C
1000_GenomesCDC25C 
Exome Variant ServerCDC25C
GNOMAD BrowserENSG00000158402
Varsome BrowserCDC25C
ACMGCDC25C variants
VarityP30307
Genomic Variants (DGV)CDC25C [DGVbeta]
DECIPHERCDC25C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDC25C 
Mutations
ICGC Data PortalCDC25C 
TCGA Data PortalCDC25C 
Broad Tumor PortalCDC25C
OASIS PortalCDC25C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDC25C  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDC25C
Mutations and Diseases : HGMDCDC25C
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCDC25C
DgiDB (Drug Gene Interaction Database)CDC25C
DoCM (Curated mutations)CDC25C
CIViC (Clinical Interpretations of Variants in Cancer)CDC25C
Cancer3DCDC25C
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM157680   
Orphanet
DisGeNETCDC25C
MedgenCDC25C
Genetic Testing Registry CDC25C
NextProtP30307 [Medical]
GENETestsCDC25C
Target ValidationCDC25C
Huge Navigator CDC25C [HugePedia]
ClinGenCDC25C
Clinical trials, drugs, therapy
MyCancerGenomeCDC25C
Protein Interactions : CTDCDC25C
Pharm GKB GenePA100
PharosP30307
Clinical trialCDC25C
Miscellaneous
canSAR (ICR)CDC25C
HarmonizomeCDC25C
DataMed IndexCDC25C
Probes
Litterature
PubMed217 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCDC25C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:03:07 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.