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CDC25C (cell division cycle 25C)

Identity

Alias_namesregulatory subunit 60
CDC25
Alias_symbol (synonym)PPP1R60
Other alias
HGNC (Hugo) CDC25C
LocusID (NCBI) 995
Atlas_Id 40006
Location 5q31.2  [Link to chromosome band 5q31]
Location_base_pair Starts at 138285265 and ends at 138331877 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FAM13B (5q31.2) / CDC25C (5q31.2)LAT2 (7q11.23) / CDC25C (5q31.2)PAIP2 (5q31.2) / CDC25C (5q31.2)
FAM13B 5q31.2 / CDC25C 5q31.2PAIP2 5q31.2 / CDC25C 5q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDC25C   1727
Cards
Entrez_Gene (NCBI)CDC25C  995  cell division cycle 25C
AliasesCDC25; PPP1R60
GeneCards (Weizmann)CDC25C
Ensembl hg19 (Hinxton)ENSG00000158402 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158402 [Gene_View]  chr5:138285265-138331877 [Contig_View]  CDC25C [Vega]
ICGC DataPortalENSG00000158402
TCGA cBioPortalCDC25C
AceView (NCBI)CDC25C
Genatlas (Paris)CDC25C
WikiGenes995
SOURCE (Princeton)CDC25C
Genetics Home Reference (NIH)CDC25C
Genomic and cartography
GoldenPath hg38 (UCSC)CDC25C  -     chr5:138285265-138331877 -  5q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDC25C  -     5q31.2   [Description]    (hg19-Feb_2009)
EnsemblCDC25C - 5q31.2 [CytoView hg19]  CDC25C - 5q31.2 [CytoView hg38]
Mapping of homologs : NCBICDC25C [Mapview hg19]  CDC25C [Mapview hg38]
OMIM157680   
Gene and transcription
Genbank (Entrez)AF086323 AF277723 AF277724 AF277725 AF277726
RefSeq transcript (Entrez)NM_001287582 NM_001287583 NM_001318098 NM_001790 NM_022809
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDC25C
Cluster EST : UnigeneHs.656 [ NCBI ]
CGAP (NCI)Hs.656
Alternative Splicing GalleryENSG00000158402
Gene ExpressionCDC25C [ NCBI-GEO ]   CDC25C [ EBI - ARRAY_EXPRESS ]   CDC25C [ SEEK ]   CDC25C [ MEM ]
Gene Expression Viewer (FireBrowse)CDC25C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)995
GTEX Portal (Tissue expression)CDC25C
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30307   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30307  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30307
Splice isoforms : SwissVarP30307
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusP30307
Domaine pattern : Prosite (Expaxy)RHODANESE_3 (PS50206)   
Domains : Interpro (EBI)MPI_Phosphatase    Rhodanese-like_dom   
Domain families : Pfam (Sanger)M-inducer_phosp (PF06617)    Rhodanese (PF00581)   
Domain families : Pfam (NCBI)pfam06617    pfam00581   
Domain families : Smart (EMBL)RHOD (SM00450)  
Conserved Domain (NCBI)CDC25C
DMDM Disease mutations995
Blocks (Seattle)CDC25C
PDB (SRS)2OJX    3BZI    3OP3   
PDB (PDBSum)2OJX    3BZI    3OP3   
PDB (IMB)2OJX    3BZI    3OP3   
PDB (RSDB)2OJX    3BZI    3OP3   
Structural Biology KnowledgeBase2OJX    3BZI    3OP3   
SCOP (Structural Classification of Proteins)2OJX    3BZI    3OP3   
CATH (Classification of proteins structures)2OJX    3BZI    3OP3   
SuperfamilyP30307
Human Protein AtlasENSG00000158402
Peptide AtlasP30307
HPRD01146
IPIIPI01012097   IPI00640320   IPI00216684   IPI00216685   IPI00816725   IPI00216683   IPI00964968   IPI00965082   
Protein Interaction databases
DIP (DOE-UCLA)P30307
IntAct (EBI)P30307
FunCoupENSG00000158402
BioGRIDCDC25C
STRING (EMBL)CDC25C
ZODIACCDC25C
Ontologies - Pathways
QuickGOP30307
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  phosphoprotein phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  nucleoplasm  cytosol  DNA replication  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  regulation of mitotic nuclear division  spermatogenesis  cell proliferation  viral process  nuclear speck  protein kinase binding  peptidyl-tyrosine dephosphorylation  perinuclear region of cytoplasm  WW domain binding  cell division  regulation of cell cycle  positive regulation of cell cycle G2/M phase transition  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  phosphoprotein phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  nucleoplasm  cytosol  DNA replication  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  regulation of mitotic nuclear division  spermatogenesis  cell proliferation  viral process  nuclear speck  protein kinase binding  peptidyl-tyrosine dephosphorylation  perinuclear region of cytoplasm  WW domain binding  cell division  regulation of cell cycle  positive regulation of cell cycle G2/M phase transition  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGCell cycle    Oocyte meiosis    Progesterone-mediated oocyte maturation    MicroRNAs in cancer   
NDEx NetworkCDC25C
Atlas of Cancer Signalling NetworkCDC25C
Wikipedia pathwaysCDC25C
Orthology - Evolution
OrthoDB995
GeneTree (enSembl)ENSG00000158402
Phylogenetic Trees/Animal Genes : TreeFamCDC25C
HOVERGENP30307
HOGENOMP30307
Homologs : HomoloGeneCDC25C
Homology/Alignments : Family Browser (UCSC)CDC25C
Gene fusions - Rearrangements
Fusion : MitelmanFAM13B/CDC25C [5q31.2/5q31.2]  [t(5;5)(q31;q31)]  
Fusion : MitelmanPAIP2/CDC25C [5q31.2/5q31.2]  [t(5;5)(q31;q31)]  
Fusion: TCGAFAM13B 5q31.2 CDC25C 5q31.2 PRAD
Fusion: TCGAPAIP2 5q31.2 CDC25C 5q31.2 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDC25C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDC25C
dbVarCDC25C
ClinVarCDC25C
1000_GenomesCDC25C 
Exome Variant ServerCDC25C
ExAC (Exome Aggregation Consortium)CDC25C (select the gene name)
Genetic variants : HAPMAP995
Genomic Variants (DGV)CDC25C [DGVbeta]
DECIPHERCDC25C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDC25C 
Mutations
ICGC Data PortalCDC25C 
TCGA Data PortalCDC25C 
Broad Tumor PortalCDC25C
OASIS PortalCDC25C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDC25C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDC25C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDC25C
DgiDB (Drug Gene Interaction Database)CDC25C
DoCM (Curated mutations)CDC25C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDC25C (select a term)
intoGenCDC25C
Cancer3DCDC25C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM157680   
Orphanet
MedgenCDC25C
Genetic Testing Registry CDC25C
NextProtP30307 [Medical]
TSGene995
GENETestsCDC25C
Target ValidationCDC25C
Huge Navigator CDC25C [HugePedia]
snp3D : Map Gene to Disease995
BioCentury BCIQCDC25C
ClinGenCDC25C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD995
Chemical/Pharm GKB GenePA100
Clinical trialCDC25C
Miscellaneous
canSAR (ICR)CDC25C (select the gene name)
Probes
Litterature
PubMed189 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDC25C
EVEXCDC25C
GoPubMedCDC25C
iHOPCDC25C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:27:35 CEST 2017

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