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CDC27 (cell division cycle 27)

Identity

Alias_namesD0S1430E
D17S978E
cell division cycle 27
cell division cycle 27 homolog (S. cerevisiae)
Alias_symbol (synonym)APC3
ANAPC3
NUC2
Other aliasCDC27Hs
H-NUC
HNUC
HGNC (Hugo) CDC27
LocusID (NCBI) 996
Atlas_Id 40007
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 47117697 and ends at 47189312 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AK3 (9p24.1) / CDC27 (17q21.32)CDC27 (17q21.32) / BRAF (7q34)CDC27 (17q21.32) / FN1 (2q35)
CDC27 (17q21.32) / GPHN (14q23.3)CDC27 (17q21.32) / MYL4 (17q21.32)CDC27 (17q21.32) / ST7L (1p13.2)
CDC27 (17q21.32) / USP32 (17q23.1)SPECC1 (17p11.2) / CDC27 (17q21.32)TRIM5 (11p15.4) / CDC27 (17q21.32)
CDC27 17q21.32 / MYL4 17q21.32CDC27 17q21.32 / ST7L 1p13.2CDC27 17q21.32 / USP32 17q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDC27   1728
Cards
Entrez_Gene (NCBI)CDC27  996  cell division cycle 27
AliasesANAPC3; APC3; CDC27Hs; D0S1430E; 
D17S978E; H-NUC; HNUC; NUC2
GeneCards (Weizmann)CDC27
Ensembl hg19 (Hinxton)ENSG00000004897 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000004897 [Gene_View]  chr17:47117697-47189312 [Contig_View]  CDC27 [Vega]
ICGC DataPortalENSG00000004897
TCGA cBioPortalCDC27
AceView (NCBI)CDC27
Genatlas (Paris)CDC27
WikiGenes996
SOURCE (Princeton)CDC27
Genetics Home Reference (NIH)CDC27
Genomic and cartography
GoldenPath hg38 (UCSC)CDC27  -     chr17:47117697-47189312 -  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDC27  -     17q21.32   [Description]    (hg19-Feb_2009)
EnsemblCDC27 - 17q21.32 [CytoView hg19]  CDC27 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBICDC27 [Mapview hg19]  CDC27 [Mapview hg38]
OMIM116946   
Gene and transcription
Genbank (Entrez)AA927469 AK296881 AK299342 AU135593 BC011656
RefSeq transcript (Entrez)NM_001114091 NM_001256 NM_001293089 NM_001293091
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDC27
Cluster EST : UnigeneHs.602766 [ NCBI ]
CGAP (NCI)Hs.602766
Alternative Splicing GalleryENSG00000004897
Gene ExpressionCDC27 [ NCBI-GEO ]   CDC27 [ EBI - ARRAY_EXPRESS ]   CDC27 [ SEEK ]   CDC27 [ MEM ]
Gene Expression Viewer (FireBrowse)CDC27 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)996
GTEX Portal (Tissue expression)CDC27
Human Protein AtlasENSG00000004897-CDC27 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30260   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30260  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30260
Splice isoforms : SwissVarP30260
PhosPhoSitePlusP30260
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)TPR-contain_dom    TPR-like_helical_dom    TPR_1    TPR_repeat   
Domain families : Pfam (Sanger)TPR_1 (PF00515)    TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam00515    pfam13181   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)CDC27
DMDM Disease mutations996
Blocks (Seattle)CDC27
PDB (SRS)3T1N    4RG6    4RG7    4RG9    4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
PDB (PDBSum)3T1N    4RG6    4RG7    4RG9    4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
PDB (IMB)3T1N    4RG6    4RG7    4RG9    4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
PDB (RSDB)3T1N    4RG6    4RG7    4RG9    4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
Structural Biology KnowledgeBase3T1N    4RG6    4RG7    4RG9    4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
SCOP (Structural Classification of Proteins)3T1N    4RG6    4RG7    4RG9    4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
CATH (Classification of proteins structures)3T1N    4RG6    4RG7    4RG9    4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
SuperfamilyP30260
Human Protein Atlas [tissue]ENSG00000004897-CDC27 [tissue]
Peptide AtlasP30260
HPRD00304
IPIIPI00294575   IPI01009266   IPI01015559   IPI00794278   IPI00981936   IPI00797796   IPI00909993   
Protein Interaction databases
DIP (DOE-UCLA)P30260
IntAct (EBI)P30260
FunCoupENSG00000004897
BioGRIDCDC27
STRING (EMBL)CDC27
ZODIACCDC27
Ontologies - Pathways
QuickGOP30260
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  nucleoplasm  anaphase-promoting complex  cytoplasm  centrosome  spindle  cytosol  spindle microtubule  metaphase/anaphase transition of mitotic cell cycle  cell proliferation  protein phosphatase binding  anaphase-promoting complex-dependent catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  protein K11-linked ubiquitination  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  nucleoplasm  anaphase-promoting complex  cytoplasm  centrosome  spindle  cytosol  spindle microtubule  metaphase/anaphase transition of mitotic cell cycle  cell proliferation  protein phosphatase binding  anaphase-promoting complex-dependent catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  protein K11-linked ubiquitination  
Pathways : KEGGCell cycle    Oocyte meiosis    Ubiquitin mediated proteolysis    Progesterone-mediated oocyte maturation    HTLV-I infection   
NDEx NetworkCDC27
Atlas of Cancer Signalling NetworkCDC27
Wikipedia pathwaysCDC27
Orthology - Evolution
OrthoDB996
GeneTree (enSembl)ENSG00000004897
Phylogenetic Trees/Animal Genes : TreeFamCDC27
HOVERGENP30260
HOGENOMP30260
Homologs : HomoloGeneCDC27
Homology/Alignments : Family Browser (UCSC)CDC27
Gene fusions - Rearrangements
Fusion : MitelmanCDC27/BRAF [17q21.32/7q34]  
Fusion : MitelmanCDC27/MYL4 [17q21.32/17q21.32]  [t(17;17)(q21;q21)]  
Fusion : MitelmanCDC27/ST7L [17q21.32/1p13.2]  [t(1;17)(p13;q21)]  
Fusion : MitelmanCDC27/USP32 [17q21.32/17q23.1]  [t(17;17)(q21;q23)]  
Fusion: TCGA_MDACCCDC27 17q21.32 MYL4 17q21.32 PRAD
Fusion: TCGA_MDACCCDC27 17q21.32 ST7L 1p13.2 BRCA
Fusion: TCGA_MDACCCDC27 17q21.32 USP32 17q23.1 BRCA
Tumor Fusion PortalCDC27
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDC27 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDC27
dbVarCDC27
ClinVarCDC27
1000_GenomesCDC27 
Exome Variant ServerCDC27
ExAC (Exome Aggregation Consortium)ENSG00000004897
GNOMAD BrowserENSG00000004897
Genetic variants : HAPMAP996
Genomic Variants (DGV)CDC27 [DGVbeta]
DECIPHERCDC27 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDC27 
Mutations
ICGC Data PortalCDC27 
TCGA Data PortalCDC27 
Broad Tumor PortalCDC27
OASIS PortalCDC27 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDC27  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDC27
intOGen PortalCDC27
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDC27
DgiDB (Drug Gene Interaction Database)CDC27
DoCM (Curated mutations)CDC27 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDC27 (select a term)
intoGenCDC27
Cancer3DCDC27(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM116946   
Orphanet
DisGeNETCDC27
MedgenCDC27
Genetic Testing Registry CDC27
NextProtP30260 [Medical]
TSGene996
GENETestsCDC27
Target ValidationCDC27
Huge Navigator CDC27 [HugePedia]
snp3D : Map Gene to Disease996
BioCentury BCIQCDC27
ClinGenCDC27
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD996
Chemical/Pharm GKB GenePA26261
Clinical trialCDC27
Miscellaneous
canSAR (ICR)CDC27 (select the gene name)
Probes
Litterature
PubMed187 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDC27
EVEXCDC27
GoPubMedCDC27
iHOPCDC27
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:06:54 CET 2017

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