CDC37 (cell division cycle 37, HSP90 cochaperone)

2003-08-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
P50CDC37
FUSION GENES

Other Information

Locus ID:

NCBI: 11140
MIM: 605065
HGNC: 1735
Ensembl: ENSG00000105401

Variants:

dbSNP: 11140
ClinVar: 11140
TCGA: ENSG00000105401
COSMIC: CDC37

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105401ENST00000222005Q16543
ENSG00000105401ENST00000222005A0A024R7B7
ENSG00000105401ENST00000588869K7EJ06
ENSG00000105401ENST00000589331K7EIU0
ENSG00000105401ENST00000589625K7EL68
ENSG00000105401ENST00000589629K7EQA9
ENSG00000105401ENST00000593124K7EKQ2

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by EGFR in CancerREACTOMER-HSA-1643713
Signaling by Ligand-Responsive EGFR Variants in CancerREACTOMER-HSA-5637815
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsREACTOMER-HSA-1236382
Signaling by EGFRvIII in CancerREACTOMER-HSA-5637812
Constitutive Signaling by EGFRvIIIREACTOMER-HSA-5637810
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB2REACTOMER-HSA-1227986
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375353992023Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.3
375353992023Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.3
351653642022Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.3
354003412022The Therapeutic Potential of Targeting Hsp90-Cdc37 Interactions in Several Diseases.0
364467912022HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.13
351653642022Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.3
354003412022The Therapeutic Potential of Targeting Hsp90-Cdc37 Interactions in Several Diseases.0
364467912022HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.13
326569992021Hsp90 interacts with Cdc37, is phosphorylated by PKA/PKC, and regulates Src phosphorylation in human sperm capacitation.6
337868142021The CDC37-HSP90 chaperone complex co-translationally degrades the nascent kinase-dead mutant of HIPK2.3
341475602021Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone.3
346274342021[Cdc37 Expression in Multiple Myeloma and Its Role in Cell Proliferation].0
326569992021Hsp90 interacts with Cdc37, is phosphorylated by PKA/PKC, and regulates Src phosphorylation in human sperm capacitation.6
337868142021The CDC37-HSP90 chaperone complex co-translationally degrades the nascent kinase-dead mutant of HIPK2.3
341475602021Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone.3

Citation

Dessen P

CDC37 (cell division cycle 37, HSP90 cochaperone)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40011/cdc37