CDC42BPA (CDC42 binding protein kinase alpha)

2006-10-01  

Identity

HGNC
LOCATION
1q42.13
LOCUSID
ALIAS
MRCK,MRCKA,PK428
FUSION GENES

Other Information

Locus ID:

NCBI: 8476
MIM: 603412
HGNC: 1737
Ensembl: ENSG00000143776

Variants:

dbSNP: 8476
ClinVar: 8476
TCGA: ENSG00000143776
COSMIC: CDC42BPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143776ENST00000334218Q5VT25
ENSG00000143776ENST00000366764A0A0A0MRJ0
ENSG00000143776ENST00000366766A0A0A0MRJ1
ENSG00000143776ENST00000366767Q5VT25
ENSG00000143776ENST00000366769Q5VT25
ENSG00000143776ENST00000429440H0Y6R0
ENSG00000143776ENST00000441725H0Y6V3
ENSG00000143776ENST00000442054H0Y5V1
ENSG00000143776ENST00000448940H0Y7V8

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
157230502005Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion.147
173444172007Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.125
119298732002Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor.55
164129802006A novel iron responsive element in the 3'UTR of human MRCKalpha.19
214577152011Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.16
182635882008Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta.13
250926572014PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction.7
251079092014Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.6
201887072010Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake.3
244864832014Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3.3

Citation

Dessen P

CDC42BPA (CDC42 binding protein kinase alpha)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43197/cdc42bpa