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CDC42BPB (CDC42 binding protein kinase beta)

Identity

Alias_namesCDC42-binding protein kinase beta (DMPK-like)
Alias_symbol (synonym)MRCKB
KIAA1124
Other alias
HGNC (Hugo) CDC42BPB
LocusID (NCBI) 9578
Atlas_Id 43198
Location 14q32.32  [Link to chromosome band 14q32]
Location_base_pair Starts at 102932379 and ends at 103057405 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDC42BPB (14q32.32) / LINC01588 (14q21.3)CDC42BPB (14q32.32) / NEDD4L (18q21.31)CDC42BPB (14q32.32) / PPP4R3A (14q32.12)
CDC42BPB (14q32.32) / RGS6 (14q24.2)CDC42BPB (14q32.32) / SPAG5 (17q11.2)CDC42BPB (14q32.32) / SYNJ2BP (14q24.2)
CDC42BPB (14q32.32) / UNC79 (14q32.12)CGA (6q14.3) / CDC42BPB (14q32.32)NBPF11 (1q21.1) / CDC42BPB (14q32.32)
SLC25A3 (12q23.1) / CDC42BPB (14q32.32)TRAF3 (14q32.32) / CDC42BPB (14q32.32)CDC42BPB 14q32.32 C14orf182
CDC42BPB 14q32.32 KIAA1409CDC42BPB 14q32.32 / RGS6 14q24.2CDC42BPB 14q32.32 SMEK1
CDC42BPB 14q32.32 / SYNJ2BP 14q24.2TRAF3 14q32.32 / CDC42BPB 14q32.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(14;14)(q21;q32) CDC42BPB/LINC01588
t(14;14)(q24;q32) CDC42BPB/RGS6
t(14;14)(q24;q32) CDC42BPB/SYNJ2BP
CDC42BPB/UNC79 (14q32)
TRAF3/CDC42BPB (14q32)


External links

Nomenclature
HGNC (Hugo)CDC42BPB   1738
Cards
Entrez_Gene (NCBI)CDC42BPB  9578  CDC42 binding protein kinase beta
AliasesMRCKB
GeneCards (Weizmann)CDC42BPB
Ensembl hg19 (Hinxton)ENSG00000198752 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198752 [Gene_View]  ENSG00000198752 [Sequence]  chr14:102932379-103057405 [Contig_View]  CDC42BPB [Vega]
ICGC DataPortalENSG00000198752
TCGA cBioPortalCDC42BPB
AceView (NCBI)CDC42BPB
Genatlas (Paris)CDC42BPB
WikiGenes9578
SOURCE (Princeton)CDC42BPB
Genetics Home Reference (NIH)CDC42BPB
Genomic and cartography
GoldenPath hg38 (UCSC)CDC42BPB  -     chr14:102932379-103057405 -  14q32.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDC42BPB  -     14q32.32   [Description]    (hg19-Feb_2009)
EnsemblCDC42BPB - 14q32.32 [CytoView hg19]  CDC42BPB - 14q32.32 [CytoView hg38]
Mapping of homologs : NCBICDC42BPB [Mapview hg19]  CDC42BPB [Mapview hg38]
OMIM614062   
Gene and transcription
Genbank (Entrez)AB032950 AF128625 AK094920 AK126684 BC047871
RefSeq transcript (Entrez)NM_006035
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDC42BPB
Cluster EST : UnigeneHs.654634 [ NCBI ]
CGAP (NCI)Hs.654634
Alternative Splicing GalleryENSG00000198752
Gene ExpressionCDC42BPB [ NCBI-GEO ]   CDC42BPB [ EBI - ARRAY_EXPRESS ]   CDC42BPB [ SEEK ]   CDC42BPB [ MEM ]
Gene Expression Viewer (FireBrowse)CDC42BPB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9578
GTEX Portal (Tissue expression)CDC42BPB
Human Protein AtlasENSG00000198752-CDC42BPB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5S2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5S2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5S2
Splice isoforms : SwissVarQ9Y5S2
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9Y5S2
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    CNH (PS50219)    CRIB (PS50108)    PH_DOMAIN (PS50003)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AGC-kinase_C    CNH_dom    CRIB_dom    DAG/PE-bd    KELK    Kinase-like_dom_sf    MRCK_beta    Myotonic_dystrophy_kinase_coil    PE/DAG-bd    PH-like_dom_sf    PH_domain    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)C1_1 (PF00130)    CNH (PF00780)    DMPK_coil (PF08826)    KELK (PF15796)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00130    pfam00780    pfam08826    pfam15796    pfam00069   
Domain families : Smart (EMBL)C1 (SM00109)  CNH (SM00036)  PBD (SM00285)  PH (SM00233)  S_TK_X (SM00133)  S_TKc (SM00220)  
Domain structure : Prodom (Prabi Lyon)Myotonic_dystrophy_kinase_coil (PD011252)   
Conserved Domain (NCBI)CDC42BPB
DMDM Disease mutations9578
Blocks (Seattle)CDC42BPB
PDB (SRS)3QFV    3TKU    4UAK    4UAL    5OTE    5OTF   
PDB (PDBSum)3QFV    3TKU    4UAK    4UAL    5OTE    5OTF   
PDB (IMB)3QFV    3TKU    4UAK    4UAL    5OTE    5OTF   
PDB (RSDB)3QFV    3TKU    4UAK    4UAL    5OTE    5OTF   
Structural Biology KnowledgeBase3QFV    3TKU    4UAK    4UAL    5OTE    5OTF   
SCOP (Structural Classification of Proteins)3QFV    3TKU    4UAK    4UAL    5OTE    5OTF   
CATH (Classification of proteins structures)3QFV    3TKU    4UAK    4UAL    5OTE    5OTF   
SuperfamilyQ9Y5S2
Human Protein Atlas [tissue]ENSG00000198752-CDC42BPB [tissue]
Peptide AtlasQ9Y5S2
HPRD08516
IPIIPI00477763   IPI01009227   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5S2
IntAct (EBI)Q9Y5S2
FunCoupENSG00000198752
BioGRIDCDC42BPB
STRING (EMBL)CDC42BPB
ZODIACCDC42BPB
Ontologies - Pathways
QuickGOQ9Y5S2
Ontology : AmiGOmagnesium ion binding  protein kinase activity  protein serine/threonine kinase activity  ATP binding  cytoplasm  cytoskeleton  plasma membrane  cell-cell junction  protein phosphorylation  protein phosphorylation  cytoskeleton organization  establishment or maintenance of cell polarity  signal transduction  cell migration  Rho GTPase binding  lamellipodium  actomyosin structure organization  cell leading edge  actin cytoskeleton reorganization  intracellular signal transduction  actomyosin  protein-containing complex binding  extracellular exosome  
Ontology : EGO-EBImagnesium ion binding  protein kinase activity  protein serine/threonine kinase activity  ATP binding  cytoplasm  cytoskeleton  plasma membrane  cell-cell junction  protein phosphorylation  protein phosphorylation  cytoskeleton organization  establishment or maintenance of cell polarity  signal transduction  cell migration  Rho GTPase binding  lamellipodium  actomyosin structure organization  cell leading edge  actin cytoskeleton reorganization  intracellular signal transduction  actomyosin  protein-containing complex binding  extracellular exosome  
NDEx NetworkCDC42BPB
Atlas of Cancer Signalling NetworkCDC42BPB
Wikipedia pathwaysCDC42BPB
Orthology - Evolution
OrthoDB9578
GeneTree (enSembl)ENSG00000198752
Phylogenetic Trees/Animal Genes : TreeFamCDC42BPB
HOVERGENQ9Y5S2
HOGENOMQ9Y5S2
Homologs : HomoloGeneCDC42BPB
Homology/Alignments : Family Browser (UCSC)CDC42BPB
Gene fusions - Rearrangements
Fusion : MitelmanCDC42BPB/LINC01588 [14q32.32/14q21.3]  
Fusion : MitelmanCDC42BPB/RGS6 [14q32.32/14q24.2]  [t(14;14)(q24;q32)]  
Fusion : MitelmanCDC42BPB/SMEK1 [14q32.32/t(14;14)(q32;q32)]  
Fusion : MitelmanCDC42BPB/SYNJ2BP [14q32.32/14q24.2]  [t(14;14)(q24;q32)]  
Fusion : MitelmanCDC42BPB/UNC79 [14q32.32/14q32.12]  [t(14;14)(q32;q32)]  
Fusion : MitelmanTRAF3/CDC42BPB [14q32.32/14q32.32]  [t(14;14)(q32;q32)]  
Fusion PortalCDC42BPB 14q32.32 C14orf182 LUAD
Fusion PortalCDC42BPB 14q32.32 KIAA1409 BRCA
Fusion PortalCDC42BPB 14q32.32 RGS6 14q24.2 SKCM
Fusion PortalCDC42BPB 14q32.32 SMEK1 HNSC
Fusion PortalCDC42BPB 14q32.32 SYNJ2BP 14q24.2 OV
Fusion PortalTRAF3 14q32.32 CDC42BPB 14q32.32 HNSC
Fusion : QuiverCDC42BPB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDC42BPB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDC42BPB
dbVarCDC42BPB
ClinVarCDC42BPB
1000_GenomesCDC42BPB 
Exome Variant ServerCDC42BPB
ExAC (Exome Aggregation Consortium)ENSG00000198752
GNOMAD BrowserENSG00000198752
Varsome BrowserCDC42BPB
Genetic variants : HAPMAP9578
Genomic Variants (DGV)CDC42BPB [DGVbeta]
DECIPHERCDC42BPB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDC42BPB 
Mutations
ICGC Data PortalCDC42BPB 
TCGA Data PortalCDC42BPB 
Broad Tumor PortalCDC42BPB
OASIS PortalCDC42BPB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDC42BPB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDC42BPB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDC42BPB
DgiDB (Drug Gene Interaction Database)CDC42BPB
DoCM (Curated mutations)CDC42BPB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDC42BPB (select a term)
intoGenCDC42BPB
Cancer3DCDC42BPB(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614062   
Orphanet
DisGeNETCDC42BPB
MedgenCDC42BPB
Genetic Testing Registry CDC42BPB
NextProtQ9Y5S2 [Medical]
TSGene9578
GENETestsCDC42BPB
Target ValidationCDC42BPB
Huge Navigator CDC42BPB [HugePedia]
snp3D : Map Gene to Disease9578
BioCentury BCIQCDC42BPB
ClinGenCDC42BPB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9578
Chemical/Pharm GKB GenePA26268
Clinical trialCDC42BPB
Miscellaneous
canSAR (ICR)CDC42BPB (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDC42BPB
EVEXCDC42BPB
GoPubMedCDC42BPB
iHOPCDC42BPB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:57:03 CET 2018

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