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CDC42EP4 (CDC42 effector protein 4)

Identity

Alias (NCBI)BORG4
CEP4
KAIA1777
HGNC (Hugo) CDC42EP4
HGNC Alias symbCEP4
KAIA1777
BORG4
MGC3740
MGC17125
HGNC Alias nameCdc42 effector protein 4
 binder of Rho GTPases 4
HGNC Previous nameCDC42 effector protein (Rho GTPase binding) 4
LocusID (NCBI) 23580
Atlas_Id 61639
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 73283624 and ends at 73312001 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDC42EP4 (17q25.1) / NEUROD2 (17q12)CDC42EP4 (17q25.1) / SDK2 (17q25.1)CDC42EP4 (17q25.1) / SEPT10 (2q13)
KLK3 (19q13.33) / CDC42EP4 (17q25.1)VMP1 (17q23.1) / CDC42EP4 (17q25.1)WIPF2 (17q21.1) / CDC42EP4 (17q25.1)
CDC42EP4 SDK2CDC42EP4 NEUROD2CDC42EP4 SEPT10
VMP1 CDC42EP4WIPF2 CDC42EP4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CDC42EP4   17147
Cards
Entrez_Gene (NCBI)CDC42EP4    CDC42 effector protein 4
AliasesBORG4; CEP4; KAIA1777
GeneCards (Weizmann)CDC42EP4
Ensembl hg19 (Hinxton)ENSG00000179604 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179604 [Gene_View]  ENSG00000179604 [Sequence]  chr17:73283624-73312001 [Contig_View]  CDC42EP4 [Vega]
ICGC DataPortalENSG00000179604
TCGA cBioPortalCDC42EP4
AceView (NCBI)CDC42EP4
Genatlas (Paris)CDC42EP4
SOURCE (Princeton)CDC42EP4
Genetics Home Reference (NIH)CDC42EP4
Genomic and cartography
GoldenPath hg38 (UCSC)CDC42EP4  -     chr17:73283624-73312001 -  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDC42EP4  -     17q25.1   [Description]    (hg19-Feb_2009)
GoldenPathCDC42EP4 - 17q25.1 [CytoView hg19]  CDC42EP4 - 17q25.1 [CytoView hg38]
ImmunoBaseENSG00000179604
Genome Data Viewer NCBICDC42EP4 [Mapview hg19]  
OMIM605468   
Gene and transcription
Genbank (Entrez)AB042237 AF099664 AK027385 AK097835 AK312536
RefSeq transcript (Entrez)NM_012121
Consensus coding sequences : CCDS (NCBI)CDC42EP4
Gene ExpressionCDC42EP4 [ NCBI-GEO ]   CDC42EP4 [ EBI - ARRAY_EXPRESS ]   CDC42EP4 [ SEEK ]   CDC42EP4 [ MEM ]
Gene Expression Viewer (FireBrowse)CDC42EP4 [ Firebrowse - Broad ]
GenevisibleExpression of CDC42EP4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23580
GTEX Portal (Tissue expression)CDC42EP4
Human Protein AtlasENSG00000179604-CDC42EP4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H3Q1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H3Q1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H3Q1
PhosPhoSitePlusQ9H3Q1
Domaine pattern : Prosite (Expaxy)CRIB (PS50108)   
Domains : Interpro (EBI)Cdc42_effect    CRIB_dom   
Domain families : Pfam (Sanger)BORG_CEP (PF14957)    PBD (PF00786)   
Domain families : Pfam (NCBI)pfam14957    pfam00786   
Domain families : Smart (EMBL)PBD (SM00285)  
Conserved Domain (NCBI)CDC42EP4
SuperfamilyQ9H3Q1
AlphaFold pdb e-kbQ9H3Q1   
Human Protein Atlas [tissue]ENSG00000179604-CDC42EP4 [tissue]
HPRD08383
Protein Interaction databases
DIP (DOE-UCLA)Q9H3Q1
IntAct (EBI)Q9H3Q1
BioGRIDCDC42EP4
STRING (EMBL)CDC42EP4
ZODIACCDC42EP4
Ontologies - Pathways
QuickGOQ9H3Q1
Ontology : AmiGORNA binding  protein binding  cytoplasm  cytoskeleton  plasma membrane  plasma membrane  adherens junction  Rho protein signal transduction  regulation of cell shape  regulation of cell shape  endomembrane system  actin cytoskeleton  microtubule cytoskeleton  positive regulation of actin filament polymerization  small GTPase binding  positive regulation of pseudopodium assembly  positive regulation of pseudopodium assembly  phagocytic vesicle  cellular response to interferon-gamma  
Ontology : EGO-EBIRNA binding  protein binding  cytoplasm  cytoskeleton  plasma membrane  plasma membrane  adherens junction  Rho protein signal transduction  regulation of cell shape  regulation of cell shape  endomembrane system  actin cytoskeleton  microtubule cytoskeleton  positive regulation of actin filament polymerization  small GTPase binding  positive regulation of pseudopodium assembly  positive regulation of pseudopodium assembly  phagocytic vesicle  cellular response to interferon-gamma  
NDEx NetworkCDC42EP4
Atlas of Cancer Signalling NetworkCDC42EP4
Wikipedia pathwaysCDC42EP4
Orthology - Evolution
OrthoDB23580
GeneTree (enSembl)ENSG00000179604
Phylogenetic Trees/Animal Genes : TreeFamCDC42EP4
Homologs : HomoloGeneCDC42EP4
Homology/Alignments : Family Browser (UCSC)CDC42EP4
Gene fusions - Rearrangements
Fusion : QuiverCDC42EP4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDC42EP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDC42EP4
dbVarCDC42EP4
ClinVarCDC42EP4
MonarchCDC42EP4
1000_GenomesCDC42EP4 
Exome Variant ServerCDC42EP4
GNOMAD BrowserENSG00000179604
Varsome BrowserCDC42EP4
ACMGCDC42EP4 variants
VarityQ9H3Q1
Genomic Variants (DGV)CDC42EP4 [DGVbeta]
DECIPHERCDC42EP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDC42EP4 
Mutations
ICGC Data PortalCDC42EP4 
TCGA Data PortalCDC42EP4 
Broad Tumor PortalCDC42EP4
OASIS PortalCDC42EP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDC42EP4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDC42EP4
Mutations and Diseases : HGMDCDC42EP4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCDC42EP4
DgiDB (Drug Gene Interaction Database)CDC42EP4
DoCM (Curated mutations)CDC42EP4
CIViC (Clinical Interpretations of Variants in Cancer)CDC42EP4
Cancer3DCDC42EP4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605468   
Orphanet
DisGeNETCDC42EP4
MedgenCDC42EP4
Genetic Testing Registry CDC42EP4
NextProtQ9H3Q1 [Medical]
GENETestsCDC42EP4
Target ValidationCDC42EP4
Huge Navigator CDC42EP4 [HugePedia]
ClinGenCDC42EP4
Clinical trials, drugs, therapy
MyCancerGenomeCDC42EP4
Protein Interactions : CTDCDC42EP4
Pharm GKB GenePA38439
PharosQ9H3Q1
Clinical trialCDC42EP4
Miscellaneous
canSAR (ICR)CDC42EP4
HarmonizomeCDC42EP4
DataMed IndexCDC42EP4
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCDC42EP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:45:32 CEST 2021

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