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CDC5L (cell division cycle 5 like)

Identity

Alias (NCBI)CDC5
CDC5-LIKE
CEF1
PCDC5RP
dJ319D22.1
HGNC (Hugo) CDC5L
HGNC Alias symbPCDC5RP
hCDC5
CEF1
CDC5
HGNC Previous nameCDC5 (cell division cycle 5, S. pombe, homolog)-like
 CDC5 cell division cycle 5-like (S. pombe)
 cell division cycle 5-like
LocusID (NCBI) 988
Atlas_Id 43199
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 44387706 and ends at 44450425 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDC5L (6p21.1) / PITPNC1 (17q24.2)CDC5L (6p21.1) / SPATS1 (6p21.1)CDC5L (6p21.1) / TMEM63B (6p21.1)
CDC5L (6p21.1) / USF2 (19q13.12)CDC5L (6p21.1) / ZNF638 (2p13.2)HNRNPA2B1 (7p15.2) / CDC5L (6p21.1)
LDB3 (10q23.2) / CDC5L (6p21.1)USF2 (19q13.12) / CDC5L (6p21.1)CDC5L 6p21.1 / PITPNC1 17q24.2
CDC5L 6p21.1 / SPATS1 6p21.1CDC5L 6p21.1 / TMEM63B 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  CDC5L/SPATS1 (6p21)
CDC5L/TMEM63B (6p21)
t(6;17)(p21;q24) CDC5L/PITPNC1

External links

Nomenclature
HGNC (Hugo)CDC5L   1743
Cards
Entrez_Gene (NCBI)CDC5L  988  cell division cycle 5 like
AliasesCDC5; CDC5-LIKE; CEF1; PCDC5RP; 
dJ319D22.1
GeneCards (Weizmann)CDC5L
Ensembl hg19 (Hinxton)ENSG00000096401 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000096401 [Gene_View]  ENSG00000096401 [Sequence]  chr6:44387706-44450425 [Contig_View]  CDC5L [Vega]
ICGC DataPortalENSG00000096401
TCGA cBioPortalCDC5L
AceView (NCBI)CDC5L
Genatlas (Paris)CDC5L
WikiGenes988
SOURCE (Princeton)CDC5L
Genetics Home Reference (NIH)CDC5L
Genomic and cartography
GoldenPath hg38 (UCSC)CDC5L  -     chr6:44387706-44450425 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDC5L  -     6p21.1   [Description]    (hg19-Feb_2009)
GoldenPathCDC5L - 6p21.1 [CytoView hg19]  CDC5L - 6p21.1 [CytoView hg38]
ImmunoBaseENSG00000096401
genome Data Viewer NCBICDC5L [Mapview hg19]  
OMIM602868   
Gene and transcription
Genbank (Entrez)AB007892 AK128737 AK299738 BC001568 BG187521
RefSeq transcript (Entrez)NM_001253
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDC5L
Alternative Splicing GalleryENSG00000096401
Gene ExpressionCDC5L [ NCBI-GEO ]   CDC5L [ EBI - ARRAY_EXPRESS ]   CDC5L [ SEEK ]   CDC5L [ MEM ]
Gene Expression Viewer (FireBrowse)CDC5L [ Firebrowse - Broad ]
GenevisibleExpression of CDC5L in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)988
GTEX Portal (Tissue expression)CDC5L
Human Protein AtlasENSG00000096401-CDC5L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99459   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99459  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99459
Splice isoforms : SwissVarQ99459
PhosPhoSitePlusQ99459
Domaine pattern : Prosite (Expaxy)HTH_MYB (PS51294)   
Domains : Interpro (EBI)Cdc5p/Cef1    Homeobox-like_sf    Myb_dom    SANT/Myb   
Domain families : Pfam (Sanger)Myb_Cef (PF11831)   
Domain families : Pfam (NCBI)pfam11831   
Domain families : Smart (EMBL)SANT (SM00717)  
Conserved Domain (NCBI)CDC5L
DMDM Disease mutations988
Blocks (Seattle)CDC5L
PDB (RSDB)2DIM    2DIN    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV   
PDB Europe2DIM    2DIN    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV   
PDB (PDBSum)2DIM    2DIN    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV   
PDB (IMB)2DIM    2DIN    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV   
Structural Biology KnowledgeBase2DIM    2DIN    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV   
SCOP (Structural Classification of Proteins)2DIM    2DIN    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV   
CATH (Classification of proteins structures)2DIM    2DIN    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV   
SuperfamilyQ99459
Human Protein Atlas [tissue]ENSG00000096401-CDC5L [tissue]
Peptide AtlasQ99459
HPRD04184
IPIIPI00465294   
Protein Interaction databases
DIP (DOE-UCLA)Q99459
IntAct (EBI)Q99459
FunCoupENSG00000096401
BioGRIDCDC5L
STRING (EMBL)CDC5L
ZODIACCDC5L
Ontologies - Pathways
QuickGOQ99459
Ontology : AmiGOmitotic cell cycle  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  Prp19 complex  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription corepressor binding  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication factor A complex  cytoplasm  DNA repair  protein phosphatase 1 binding  membrane  nuclear speck  protein kinase binding  leucine zipper domain binding  cellular response to fibroblast growth factor stimulus  positive regulation of transcription by RNA polymerase II  perinuclear region of cytoplasm  U2-type catalytic step 2 spliceosome  catalytic step 2 spliceosome  cellular response to interleukin-2  WD40-repeat domain binding  signal transduction involved in DNA damage checkpoint  cellular response to wortmannin  cellular response to nerve growth factor stimulus  cellular response to prolactin  
Ontology : EGO-EBImitotic cell cycle  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  Prp19 complex  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription corepressor binding  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication factor A complex  cytoplasm  DNA repair  protein phosphatase 1 binding  membrane  nuclear speck  protein kinase binding  leucine zipper domain binding  cellular response to fibroblast growth factor stimulus  positive regulation of transcription by RNA polymerase II  perinuclear region of cytoplasm  U2-type catalytic step 2 spliceosome  catalytic step 2 spliceosome  cellular response to interleukin-2  WD40-repeat domain binding  signal transduction involved in DNA damage checkpoint  cellular response to wortmannin  cellular response to nerve growth factor stimulus  cellular response to prolactin  
Pathways : KEGGSpliceosome   
NDEx NetworkCDC5L
Atlas of Cancer Signalling NetworkCDC5L
Wikipedia pathwaysCDC5L
Orthology - Evolution
OrthoDB988
GeneTree (enSembl)ENSG00000096401
Phylogenetic Trees/Animal Genes : TreeFamCDC5L
HOGENOMQ99459
Homologs : HomoloGeneCDC5L
Homology/Alignments : Family Browser (UCSC)CDC5L
Gene fusions - Rearrangements
Fusion : MitelmanCDC5L/PITPNC1 [6p21.1/17q24.2]  
Fusion : MitelmanCDC5L/SPATS1 [6p21.1/6p21.1]  
Fusion : MitelmanCDC5L/TMEM63B [6p21.1/6p21.1]  
Fusion PortalCDC5L 6p21.1 PITPNC1 17q24.2 BRCA
Fusion PortalCDC5L 6p21.1 SPATS1 6p21.1 BRCA
Fusion PortalCDC5L 6p21.1 TMEM63B 6p21.1 BLCA
Fusion : QuiverCDC5L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDC5L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDC5L
dbVarCDC5L
ClinVarCDC5L
MonarchCDC5L
1000_GenomesCDC5L 
Exome Variant ServerCDC5L
GNOMAD BrowserENSG00000096401
Varsome BrowserCDC5L
Genetic variants : HAPMAP988
Genomic Variants (DGV)CDC5L [DGVbeta]
DECIPHERCDC5L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDC5L 
Mutations
ICGC Data PortalCDC5L 
TCGA Data PortalCDC5L 
Broad Tumor PortalCDC5L
OASIS PortalCDC5L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDC5L  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDC5L
Mutations and Diseases : HGMDCDC5L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDC5L
DgiDB (Drug Gene Interaction Database)CDC5L
DoCM (Curated mutations)CDC5L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDC5L (select a term)
intoGenCDC5L
Cancer3DCDC5L(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602868   
Orphanet
DisGeNETCDC5L
MedgenCDC5L
Genetic Testing Registry CDC5L
NextProtQ99459 [Medical]
TSGene988
GENETestsCDC5L
Target ValidationCDC5L
Huge Navigator CDC5L [HugePedia]
snp3D : Map Gene to Disease988
BioCentury BCIQCDC5L
ClinGenCDC5L
Clinical trials, drugs, therapy
Protein Interactions : CTD988
Pharm GKB GenePA26270
Clinical trialCDC5L
Miscellaneous
canSAR (ICR)CDC5L (select the gene name)
HarmonizomeCDC5L
DataMed IndexCDC5L
Probes
Litterature
PubMed152 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDC5L
EVEXCDC5L
GoPubMedCDC5L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:05:15 CEST 2020
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