Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CDCA2 (cell division cycle associated 2)

Identity

Alias (NCBI)PPP1R81
Repo-Man
HGNC (Hugo) CDCA2
HGNC Alias symbRepo-Man
PPP1R81
HGNC Alias nameprotein phosphatase 1, regulatory subunit 81
LocusID (NCBI) 157313
Atlas_Id 53500
Location 8p21.2  [Link to chromosome band 8p21]
Location_base_pair Starts at 25459233 and ends at 25507911 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDCA2 (8p21.2) / ADAM28 (8p21.2)CDCA2 8p21.2 / ADAM28 8p21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  CDCA2/ADAM28 (8p21)

External links

Nomenclature
HGNC (Hugo)CDCA2   14623
Cards
Entrez_Gene (NCBI)CDCA2    cell division cycle associated 2
AliasesPPP1R81; Repo-Man
GeneCards (Weizmann)CDCA2
Ensembl hg19 (Hinxton)ENSG00000184661 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184661 [Gene_View]  ENSG00000184661 [Sequence]  chr8:25459233-25507911 [Contig_View]  CDCA2 [Vega]
ICGC DataPortalENSG00000184661
TCGA cBioPortalCDCA2
AceView (NCBI)CDCA2
Genatlas (Paris)CDCA2
SOURCE (Princeton)CDCA2
Genetics Home Reference (NIH)CDCA2
Genomic and cartography
GoldenPath hg38 (UCSC)CDCA2  -     chr8:25459233-25507911 +  8p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDCA2  -     8p21.2   [Description]    (hg19-Feb_2009)
GoldenPathCDCA2 - 8p21.2 [CytoView hg19]  CDCA2 - 8p21.2 [CytoView hg38]
ImmunoBaseENSG00000184661
genome Data Viewer NCBICDCA2 [Mapview hg19]  
OMIM618785   
Gene and transcription
Genbank (Entrez)AA678348 AI022757 AK092164 AK098670 AK292505
RefSeq transcript (Entrez)NM_001317906 NM_001317907 NM_152562
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDCA2
Alternative Splicing GalleryENSG00000184661
Gene ExpressionCDCA2 [ NCBI-GEO ]   CDCA2 [ EBI - ARRAY_EXPRESS ]   CDCA2 [ SEEK ]   CDCA2 [ MEM ]
Gene Expression Viewer (FireBrowse)CDCA2 [ Firebrowse - Broad ]
GenevisibleExpression of CDCA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)157313
GTEX Portal (Tissue expression)CDCA2
Human Protein AtlasENSG00000184661-CDCA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ69YH5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ69YH5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ69YH5
Splice isoforms : SwissVarQ69YH5
PhosPhoSitePlusQ69YH5
Domains : Interpro (EBI)CDCA2    PP1-bd   
Domain families : Pfam (Sanger)PP1_bind (PF15276)   
Domain families : Pfam (NCBI)pfam15276   
Conserved Domain (NCBI)CDCA2
Blocks (Seattle)CDCA2
PDB (RSDB)5INB    5IOH    5SW9   
PDB Europe5INB    5IOH    5SW9   
PDB (PDBSum)5INB    5IOH    5SW9   
PDB (IMB)5INB    5IOH    5SW9   
Structural Biology KnowledgeBase5INB    5IOH    5SW9   
SCOP (Structural Classification of Proteins)5INB    5IOH    5SW9   
CATH (Classification of proteins structures)5INB    5IOH    5SW9   
SuperfamilyQ69YH5
Human Protein Atlas [tissue]ENSG00000184661-CDCA2 [tissue]
Peptide AtlasQ69YH5
HPRD13014
IPIIPI00465387   IPI00845514   IPI00973127   
Protein Interaction databases
DIP (DOE-UCLA)Q69YH5
IntAct (EBI)Q69YH5
BioGRIDCDCA2
STRING (EMBL)CDCA2
ZODIACCDCA2
Ontologies - Pathways
QuickGOQ69YH5
Ontology : AmiGOnucleoplasm  chromosome  cytosol  cell cycle  chromosome segregation  positive regulation of protein dephosphorylation  cell division  
Ontology : EGO-EBInucleoplasm  chromosome  cytosol  cell cycle  chromosome segregation  positive regulation of protein dephosphorylation  cell division  
NDEx NetworkCDCA2
Atlas of Cancer Signalling NetworkCDCA2
Wikipedia pathwaysCDCA2
Orthology - Evolution
OrthoDB157313
GeneTree (enSembl)ENSG00000184661
Phylogenetic Trees/Animal Genes : TreeFamCDCA2
HOGENOMQ69YH5
Homologs : HomoloGeneCDCA2
Homology/Alignments : Family Browser (UCSC)CDCA2
Gene fusions - Rearrangements
Fusion : MitelmanCDCA2/ADAM28 [8p21.2/8p21.2]  
Fusion PortalCDCA2 8p21.2 ADAM28 8p21.2 BRCA
Fusion : QuiverCDCA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDCA2 [hg38]
dbVarCDCA2
ClinVarCDCA2
MonarchCDCA2
1000_GenomesCDCA2 
Exome Variant ServerCDCA2
GNOMAD BrowserENSG00000184661
Varsome BrowserCDCA2
Genomic Variants (DGV)CDCA2 [DGVbeta]
DECIPHERCDCA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDCA2 
Mutations
ICGC Data PortalCDCA2 
TCGA Data PortalCDCA2 
Broad Tumor PortalCDCA2
OASIS PortalCDCA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDCA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDCA2
Mutations and Diseases : HGMDCDCA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDCA2
DgiDB (Drug Gene Interaction Database)CDCA2
DoCM (Curated mutations)CDCA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDCA2 (select a term)
intoGenCDCA2
Cancer3DCDCA2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618785   
Orphanet
DisGeNETCDCA2
MedgenCDCA2
Genetic Testing Registry CDCA2
NextProtQ69YH5 [Medical]
GENETestsCDCA2
Target ValidationCDCA2
Huge Navigator CDCA2 [HugePedia]
ClinGenCDCA2
Clinical trials, drugs, therapy
MyCancerGenomeCDCA2
Protein Interactions : CTD
Pharm GKB GenePA26275
PharosQ69YH5
Clinical trialCDCA2
Miscellaneous
canSAR (ICR)CDCA2 (select the gene name)
HarmonizomeCDCA2
DataMed IndexCDCA2
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCDCA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:09:15 CET 2021
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