CDH11 (cadherin 11)

2003-02-01  

Identity

HGNC
CDH11
LOCATION
16q21
LOCUSID
1009
ALIAS
CAD11,CDHOB,ESWS,OB,OSF-4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1009
MIM: 600023
HGNC: 1750
Ensembl: ENSG00000140937

Variants:

dbSNP: 1009
ClinVar: 1009
TCGA: ENSG00000140937
COSMIC: CDH11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140937ENST00000268603P55287
ENSG00000140937ENST00000394156P55287
ENSG00000140937ENST00000562325H3BR78
ENSG00000140937ENST00000562712H3BP26
ENSG00000140937ENST00000562882H3BQB5
ENSG00000140937ENST00000562998H3BPQ2
ENSG00000140937ENST00000564317H3BSM4
ENSG00000140937ENST00000566827H3BUU9
ENSG00000140937ENST00000567934H3BQH2
ENSG00000140937ENST00000619158A0A087X227

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199962882010MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1.139
187083582008Cadherin-11 promotes the metastasis of prostate cancer cells to bone.74
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
215368772011Cadherin-11 regulates fibroblast inflammation.50
155095452004USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts.49
219903762012Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition.48
185757462008Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone.36
166516162006Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro.32
221390842012The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas.31
222675452012Cadherin-11, a marker of the mesenchymal phenotype, regulates glioblastoma cell migration and survival in vivo.29

Citation

Dessen P

CDH11 (cadherin 11)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/527/cdh11