Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CDH19 (cadherin 19)

Identity

Alias_namescadherin 19
Alias_symbol (synonym)CDH7
Other aliasCDH7L2
HGNC (Hugo) CDH19
LocusID (NCBI) 28513
Atlas_Id 40022
Location 18q22.1  [Link to chromosome band 18q22]
Location_base_pair Starts at 66501187 and ends at 66604138 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DEPDC5 (22q12.2) / CDH19 (18q22.1)NEDD4L (18q21.31) / CDH19 (18q22.1)SERPINB5 (18q21.33) / CDH19 (18q22.1)
DEPDC5 22q12.2 / CDH19 18q22.1NEDD4L 18q21.31 / CDH19 18q22.1SERPINB5 18q21.33 / CDH19 18q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(18;18)(q21;q22) NEDD4L/CDH19
t(18;18)(q21;q22) SERPINB5/CDH19
t(18;22)(q22;q12) DEPDC5/CDH19

External links

Nomenclature
HGNC (Hugo)CDH19   1758
Cards
Entrez_Gene (NCBI)CDH19  28513  cadherin 19
AliasesCDH7; CDH7L2
GeneCards (Weizmann)CDH19
Ensembl hg19 (Hinxton)ENSG00000071991 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000071991 [Gene_View]  ENSG00000071991 [Sequence]  chr18:66501187-66604138 [Contig_View]  CDH19 [Vega]
ICGC DataPortalENSG00000071991
TCGA cBioPortalCDH19
AceView (NCBI)CDH19
Genatlas (Paris)CDH19
WikiGenes28513
SOURCE (Princeton)CDH19
Genetics Home Reference (NIH)CDH19
Genomic and cartography
GoldenPath hg38 (UCSC)CDH19  -     chr18:66501187-66604138 -  18q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDH19  -     18q22.1   [Description]    (hg19-Feb_2009)
EnsemblCDH19 - 18q22.1 [CytoView hg19]  CDH19 - 18q22.1 [CytoView hg38]
Mapping of homologs : NCBICDH19 [Mapview hg19]  CDH19 [Mapview hg38]
OMIM603016   
Gene and transcription
Genbank (Entrez)AA331759 AF047826 AJ007607 AK304000 AK315257
RefSeq transcript (Entrez)NM_001271028 NM_021153
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDH19
Cluster EST : UnigeneHs.42771 [ NCBI ]
CGAP (NCI)Hs.42771
Alternative Splicing GalleryENSG00000071991
Gene ExpressionCDH19 [ NCBI-GEO ]   CDH19 [ EBI - ARRAY_EXPRESS ]   CDH19 [ SEEK ]   CDH19 [ MEM ]
Gene Expression Viewer (FireBrowse)CDH19 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)28513
GTEX Portal (Tissue expression)CDH19
Human Protein AtlasENSG00000071991-CDH19 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H159   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H159  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H159
Splice isoforms : SwissVarQ9H159
PhosPhoSitePlusQ9H159
Domaine pattern : Prosite (Expaxy)CADHERIN_1 (PS00232)    CADHERIN_2 (PS50268)   
Domains : Interpro (EBI)Cadherin    Cadherin-like    Cadherin_CS    Cadherin_cytoplasmic-dom    Catenin_binding_dom_sf   
Domain families : Pfam (Sanger)Cadherin (PF00028)    Cadherin_C (PF01049)   
Domain families : Pfam (NCBI)pfam00028    pfam01049   
Domain families : Smart (EMBL)CA (SM00112)  
Conserved Domain (NCBI)CDH19
DMDM Disease mutations28513
Blocks (Seattle)CDH19
SuperfamilyQ9H159
Human Protein Atlas [tissue]ENSG00000071991-CDH19 [tissue]
Peptide AtlasQ9H159
HPRD04311
IPIIPI00028135   IPI01009632   IPI00639941   
Protein Interaction databases
DIP (DOE-UCLA)Q9H159
IntAct (EBI)Q9H159
FunCoupENSG00000071991
BioGRIDCDH19
STRING (EMBL)CDH19
ZODIACCDH19
Ontologies - Pathways
QuickGOQ9H159
Ontology : AmiGOcell morphogenesis  calcium ion binding  calcium ion binding  plasma membrane  plasma membrane  cell-cell adherens junction  cell-cell junction assembly  homophilic cell adhesion via plasma membrane adhesion molecules  homophilic cell adhesion via plasma membrane adhesion molecules  multicellular organism development  cytoskeletal protein binding  cell surface  integral component of membrane  calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  catenin complex  adherens junction organization  protein homodimerization activity  cell-cell adhesion mediated by cadherin  cadherin binding  
Ontology : EGO-EBIcell morphogenesis  calcium ion binding  calcium ion binding  plasma membrane  plasma membrane  cell-cell adherens junction  cell-cell junction assembly  homophilic cell adhesion via plasma membrane adhesion molecules  homophilic cell adhesion via plasma membrane adhesion molecules  multicellular organism development  cytoskeletal protein binding  cell surface  integral component of membrane  calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  catenin complex  adherens junction organization  protein homodimerization activity  cell-cell adhesion mediated by cadherin  cadherin binding  
NDEx NetworkCDH19
Atlas of Cancer Signalling NetworkCDH19
Wikipedia pathwaysCDH19
Orthology - Evolution
OrthoDB28513
GeneTree (enSembl)ENSG00000071991
Phylogenetic Trees/Animal Genes : TreeFamCDH19
HOVERGENQ9H159
HOGENOMQ9H159
Homologs : HomoloGeneCDH19
Homology/Alignments : Family Browser (UCSC)CDH19
Gene fusions - Rearrangements
Fusion : MitelmanDEPDC5/CDH19 [22q12.2/18q22.1]  [t(18;22)(q22;q12)]  
Fusion : MitelmanNEDD4L/CDH19 [18q21.31/18q22.1]  [t(18;18)(q21;q22)]  
Fusion : MitelmanSERPINB5/CDH19 [18q21.33/18q22.1]  [t(18;18)(q21;q22)]  
Fusion PortalDEPDC5 22q12.2 CDH19 18q22.1 BRCA
Fusion PortalNEDD4L 18q21.31 CDH19 18q22.1 HNSC
Fusion PortalSERPINB5 18q21.33 CDH19 18q22.1 LUAD
Fusion : QuiverCDH19
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDH19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDH19
dbVarCDH19
ClinVarCDH19
1000_GenomesCDH19 
Exome Variant ServerCDH19
ExAC (Exome Aggregation Consortium)ENSG00000071991
GNOMAD BrowserENSG00000071991
Varsome BrowserCDH19
Genetic variants : HAPMAP28513
Genomic Variants (DGV)CDH19 [DGVbeta]
DECIPHERCDH19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDH19 
Mutations
ICGC Data PortalCDH19 
TCGA Data PortalCDH19 
Broad Tumor PortalCDH19
OASIS PortalCDH19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDH19  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDH19
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDH19
DgiDB (Drug Gene Interaction Database)CDH19
DoCM (Curated mutations)CDH19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDH19 (select a term)
intoGenCDH19
Cancer3DCDH19(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603016   
Orphanet
DisGeNETCDH19
MedgenCDH19
Genetic Testing Registry CDH19
NextProtQ9H159 [Medical]
TSGene28513
GENETestsCDH19
Target ValidationCDH19
Huge Navigator CDH19 [HugePedia]
snp3D : Map Gene to Disease28513
BioCentury BCIQCDH19
ClinGenCDH19
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD28513
Chemical/Pharm GKB GenePA26292
Clinical trialCDH19
Miscellaneous
canSAR (ICR)CDH19 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDH19
EVEXCDH19
GoPubMedCDH19
iHOPCDH19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:14:24 CEST 2018
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