CDH4 (cadherin 4)

2003-11-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
CAD4,R-CAD,RCAD
FUSION GENES

Other Information

Locus ID:

NCBI: 1002
MIM: 603006
HGNC: 1763
Ensembl: ENSG00000179242

Variants:

dbSNP: 1002
ClinVar: 1002
TCGA: ENSG00000179242
COSMIC: CDH4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179242ENST00000543233P55283
ENSG00000179242ENST00000611855A0A087WX99
ENSG00000179242ENST00000614565P55283

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Developmental BiologyREACTOMER-HSA-1266738
MyogenesisREACTOMER-HSA-525793
CDO in myogenesisREACTOMER-HSA-375170

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
155486792004Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer.33
222191822012Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment.31
167860012006Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn).29
216653612011CDH4 as a novel putative tumor suppressor gene epigenetically silenced by promoter hypermethylation in nasopharyngeal carcinoma.21
151430712004R-cadherin influences cell motility via Rho family GTPases.20
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
197248952009Association of gene polymorphisms with chronic kidney disease in Japanese individuals.7
277656302016Long non-coding RNA linc-cdh4-2 inhibits the migration and invasion of HCC cells by targeting R-cadherin pathway.7
244290272014The prognostic value of P-cadherin in non-muscle-invasive bladder cancer.6

Citation

Dessen P

CDH4 (cadherin 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40026/cdh4