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CDH5 (cadherin 5, type 2 (vascular endothelium))

Identity

Other names7B4
CD144
HGNC (Hugo) CDH5
LocusID (NCBI) 1003
Location 16q21
Location_base_pair Starts at 66400525 and ends at 66438689 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CDH5   1764
Cards
Entrez_Gene (NCBI)CDH5  1003  cadherin 5, type 2 (vascular endothelium)
GeneCards (Weizmann)CDH5
Ensembl (Hinxton)ENSG00000179776 [Gene_View]  chr16:66400525-66438689 [Contig_View]  CDH5 [Vega]
ICGC DataPortalENSG00000179776
cBioPortalCDH5
AceView (NCBI)CDH5
Genatlas (Paris)CDH5
WikiGenes1003
SOURCE (Princeton)NM_001114117 NM_001795
Genomic and cartography
GoldenPath (UCSC)CDH5  -  16q21   chr16:66400525-66438689 +  16q21   [Description]    (hg19-Feb_2009)
EnsemblCDH5 - 16q21 [CytoView]
Mapping of homologs : NCBICDH5 [Mapview]
OMIM601120   
Gene and transcription
Genbank (Entrez)AB035304 AB209908 AK300299 AK300322 AK300461
RefSeq transcript (Entrez)NM_001114117 NM_001795
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NT_010498 NW_001838290 NW_004929402
Consensus coding sequences : CCDS (NCBI)CDH5
Cluster EST : UnigeneHs.76206 [ NCBI ]
CGAP (NCI)Hs.76206
Alternative Splicing : Fast-db (Paris)GSHG0011255
Alternative Splicing GalleryENSG00000179776
Gene ExpressionCDH5 [ NCBI-GEO ]     CDH5 [ SEEK ]   CDH5 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33151 (Uniprot)
NextProtP33151  [Medical]
With graphics : InterProP33151
Splice isoforms : SwissVarP33151 (Swissvar)
Domaine pattern : Prosite (Expaxy)CADHERIN_1 (PS00232)    CADHERIN_2 (PS50268)   
Domains : Interpro (EBI)Cadherin [organisation]   Cadherin-like [organisation]   Cadherin_CS [organisation]   Cadherin_cytoplasmic-dom [organisation]   Catenin_binding_dom [organisation]  
Related proteins : CluSTrP33151
Domain families : Pfam (Sanger)Cadherin (PF00028)    Cadherin_C (PF01049)   
Domain families : Pfam (NCBI)pfam00028    pfam01049   
Domain families : Smart (EMBL)CA (SM00112)  
DMDM Disease mutations1003
Blocks (Seattle)P33151
Human Protein AtlasENSG00000179776 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP33151
HPRD03075
IPIIPI00012792   IPI01011095   IPI01011586   IPI00607725   
Protein Interaction databases
DIP (DOE-UCLA)P33151
IntAct (EBI)P33151
FunCoupENSG00000179776
BioGRIDCDH5
InParanoidP33151
Interologous Interaction database P33151
IntegromeDBCDH5
STRING (EMBL)CDH5
Ontologies - Pathways
Ontology : AmiGOblood vessel maturation  receptor binding  calcium ion binding  protein binding  plasma membrane  cell-cell junction  tight junction  homophilic cell adhesion  beta-catenin binding  negative regulation of cell proliferation  membrane  integral component of membrane  protein phosphatase binding  cell junction  cell junction assembly  adherens junction organization  ion channel binding  cell-cell junction organization  regulation of establishment of cell polarity  
Ontology : EGO-EBIblood vessel maturation  receptor binding  calcium ion binding  protein binding  plasma membrane  cell-cell junction  tight junction  homophilic cell adhesion  beta-catenin binding  negative regulation of cell proliferation  membrane  integral component of membrane  protein phosphatase binding  cell junction  cell junction assembly  adherens junction organization  ion channel binding  cell-cell junction organization  regulation of establishment of cell polarity  
Pathways : KEGGCell adhesion molecules (CAMs)    Leukocyte transendothelial migration   
Protein Interaction DatabaseCDH5
Wikipedia pathwaysCDH5
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CDH5
snp3D : Map Gene to Disease1003
SNP (GeneSNP Utah)CDH5
SNP : HGBaseCDH5
Genetic variants : HAPMAPCDH5
Exome VariantCDH5
1000_GenomesCDH5 
ICGC programENSG00000179776 
Somatic Mutations in Cancer : COSMICCDH5 
CONAN: Copy Number AnalysisCDH5 
Mutations and Diseases : HGMDCDH5
Mutations and Diseases : intOGenCDH5
Genomic VariantsCDH5  CDH5 [DGVbeta]
dbVarCDH5
ClinVarCDH5
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM601120   
MedgenCDH5
GENETestsCDH5
Disease Genetic AssociationCDH5
Huge Navigator CDH5 [HugePedia]  CDH5 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCDH5
Homology/Alignments : Family Browser (UCSC)CDH5
Phylogenetic Trees/Animal Genes : TreeFamCDH5
Chemical/Protein Interactions : CTD1003
Chemical/Pharm GKB GenePA26301
Clinical trialCDH5
Cancer Resource (Charite)ENSG00000179776
Other databases
Probes
Litterature
PubMed145 Pubmed reference(s) in Entrez
CoreMineCDH5
iHOPCDH5
OncoSearchCDH5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:41:39 CEST 2014

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