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CDH6 (cadherin 6)

Identity

Alias (NCBI)CAD6
KCAD
HGNC (Hugo) CDH6
HGNC Alias nameK-Cadherin
HGNC Previous namecadherin 6, type 2, K-cadherin (fetal kidney)
LocusID (NCBI) 1004
Atlas_Id 40028
Location 5p13.3  [Link to chromosome band 5p13]
Location_base_pair Starts at 31193686 and ends at 31329146 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUP133 (1q42.13) / CDH6 (5p13.3)NUP133 1q42.13 / CDH6 5p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CDH6   1765
Cards
Entrez_Gene (NCBI)CDH6    cadherin 6
AliasesCAD6; KCAD
GeneCards (Weizmann)CDH6
Ensembl hg19 (Hinxton)ENSG00000113361 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113361 [Gene_View]  ENSG00000113361 [Sequence]  chr5:31193686-31329146 [Contig_View]  CDH6 [Vega]
ICGC DataPortalENSG00000113361
TCGA cBioPortalCDH6
AceView (NCBI)CDH6
Genatlas (Paris)CDH6
SOURCE (Princeton)CDH6
Genetics Home Reference (NIH)CDH6
Genomic and cartography
GoldenPath hg38 (UCSC)CDH6  -     chr5:31193686-31329146 +  5p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDH6  -     5p13.3   [Description]    (hg19-Feb_2009)
GoldenPathCDH6 - 5p13.3 [CytoView hg19]  CDH6 - 5p13.3 [CytoView hg38]
ImmunoBaseENSG00000113361
Genome Data Viewer NCBICDH6 [Mapview hg19]  
OMIM603007   
Gene and transcription
Genbank (Entrez)AK024238 AK291290 AL049227 AU130185 BC000019
RefSeq transcript (Entrez)NM_001362435 NM_004932
Consensus coding sequences : CCDS (NCBI)CDH6
Gene ExpressionCDH6 [ NCBI-GEO ]   CDH6 [ EBI - ARRAY_EXPRESS ]   CDH6 [ SEEK ]   CDH6 [ MEM ]
Gene Expression Viewer (FireBrowse)CDH6 [ Firebrowse - Broad ]
GenevisibleExpression of CDH6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1004
GTEX Portal (Tissue expression)CDH6
Human Protein AtlasENSG00000113361-CDH6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55285   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55285  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55285
PhosPhoSitePlusP55285
Domaine pattern : Prosite (Expaxy)CADHERIN_1 (PS00232)    CADHERIN_2 (PS50268)   
Domains : Interpro (EBI)Cadherin    Cadherin-like_dom    Cadherin-like_sf    Cadherin_CS    Cadherin_cytoplasmic-dom    Catenin-bd_sf   
Domain families : Pfam (Sanger)Cadherin (PF00028)    Cadherin_C (PF01049)   
Domain families : Pfam (NCBI)pfam00028    pfam01049   
Domain families : Smart (EMBL)CA (SM00112)  
Conserved Domain (NCBI)CDH6
PDB (RSDB)5VEB   
PDB Europe5VEB   
PDB (PDBSum)5VEB   
PDB (IMB)5VEB   
Structural Biology KnowledgeBase5VEB   
SCOP (Structural Classification of Proteins)5VEB   
CATH (Classification of proteins structures)5VEB   
SuperfamilyP55285
AlphaFold pdb e-kbP55285   
Human Protein Atlas [tissue]ENSG00000113361-CDH6 [tissue]
HPRD04305
Protein Interaction databases
DIP (DOE-UCLA)P55285
IntAct (EBI)P55285
BioGRIDCDH6
STRING (EMBL)CDH6
ZODIACCDH6
Ontologies - Pathways
QuickGOP55285
Ontology : AmiGOcell morphogenesis  calcium ion binding  nucleoplasm  plasma membrane  plasma membrane  adherens junction  cell-cell junction assembly  cell adhesion  homophilic cell adhesion via plasma membrane adhesion molecules  Notch signaling pathway  multicellular organism development  integral component of membrane  calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  catenin complex  cell junction  adherens junction organization  adherens junction organization  cadherin binding  cell-cell adhesion via plasma-membrane adhesion molecules  
Ontology : EGO-EBIcell morphogenesis  calcium ion binding  nucleoplasm  plasma membrane  plasma membrane  adherens junction  cell-cell junction assembly  cell adhesion  homophilic cell adhesion via plasma membrane adhesion molecules  Notch signaling pathway  multicellular organism development  integral component of membrane  calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  catenin complex  cell junction  adherens junction organization  adherens junction organization  cadherin binding  cell-cell adhesion via plasma-membrane adhesion molecules  
NDEx NetworkCDH6
Atlas of Cancer Signalling NetworkCDH6
Wikipedia pathwaysCDH6
Orthology - Evolution
OrthoDB1004
GeneTree (enSembl)ENSG00000113361
Phylogenetic Trees/Animal Genes : TreeFamCDH6
Homologs : HomoloGeneCDH6
Homology/Alignments : Family Browser (UCSC)CDH6
Gene fusions - Rearrangements
Fusion : MitelmanNUP133/CDH6 [1q42.13/5p13.3]  
Fusion : QuiverCDH6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDH6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDH6
dbVarCDH6
ClinVarCDH6
MonarchCDH6
1000_GenomesCDH6 
Exome Variant ServerCDH6
GNOMAD BrowserENSG00000113361
Varsome BrowserCDH6
ACMGCDH6 variants
VarityP55285
Genomic Variants (DGV)CDH6 [DGVbeta]
DECIPHERCDH6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDH6 
Mutations
ICGC Data PortalCDH6 
TCGA Data PortalCDH6 
Broad Tumor PortalCDH6
OASIS PortalCDH6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDH6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDH6
Mutations and Diseases : HGMDCDH6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCDH6
DgiDB (Drug Gene Interaction Database)CDH6
DoCM (Curated mutations)CDH6
CIViC (Clinical Interpretations of Variants in Cancer)CDH6
Cancer3DCDH6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603007   
Orphanet
DisGeNETCDH6
MedgenCDH6
Genetic Testing Registry CDH6
NextProtP55285 [Medical]
GENETestsCDH6
Target ValidationCDH6
Huge Navigator CDH6 [HugePedia]
ClinGenCDH6
Clinical trials, drugs, therapy
MyCancerGenomeCDH6
Protein Interactions : CTDCDH6
Pharm GKB GenePA26302
PharosP55285
Clinical trialCDH6
Miscellaneous
canSAR (ICR)CDH6
HarmonizomeCDH6
DataMed IndexCDH6
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCDH6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:03:13 CEST 2021

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