| Nomenclature |
|---|
| HGNC (Hugo) | CDK1 1722 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CDK1 983 cyclin dependent kinase 1 |
| Aliases | CDC2; CDC28A; P34CDC2 |
| GeneCards (Weizmann) | CDK1 |
| Ensembl hg19 (Hinxton) | ENSG00000170312 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000170312 [Gene_View] ENSG00000170312 [Sequence] chr10:60778454-60794852 [Contig_View] CDK1 [Vega] |
| ICGC DataPortal | ENSG00000170312 |
| TCGA cBioPortal | CDK1 |
| AceView (NCBI) | CDK1 |
| Genatlas (Paris) | CDK1 |
| WikiGenes | 983 |
| SOURCE (Princeton) | CDK1 |
| Genetics Home Reference (NIH) | CDK1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CDK1 - chr10:60778454-60794852 + 10q21.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CDK1 - 10q21.2 [Description] (hg19-Feb_2009) |
| Ensembl | CDK1 - 10q21.2 [CytoView hg19] CDK1 - 10q21.2 [CytoView hg38] |
| Mapping of homologs : NCBI | CDK1 [Mapview hg19] CDK1 [Mapview hg38] |
| OMIM | 116940 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AA459484 AK291939 AK295741 AW976143 BC014563 |
| RefSeq transcript (Entrez) | NM_001130829 NM_001170406 NM_001170407 NM_001320918 NM_001786 NM_033379 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | CDK1 |
| Cluster EST : Unigene | Hs.732435 [ NCBI ] |
| CGAP (NCI) | Hs.732435 |
| Alternative Splicing Gallery | ENSG00000170312 |
| Gene Expression | CDK1 [ NCBI-GEO ] CDK1 [ EBI - ARRAY_EXPRESS ]
CDK1 [ SEEK ] CDK1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CDK1 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 983 |
| GTEX Portal (Tissue expression) | CDK1 |
| Human Protein Atlas | ENSG00000170312-CDK1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P06493 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P06493 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P06493 |
| Splice isoforms : SwissVar | P06493 |
| Catalytic activity : Enzyme | 2.7.11.22 [ Enzyme-Expasy ] 2.7.11.222.7.11.22 [ IntEnz-EBI ] 2.7.11.22 [ BRENDA ] 2.7.11.22 [ KEGG ] |
| PhosPhoSitePlus | P06493 |
| Domaine pattern : Prosite (Expaxy) | PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) |
| Domains : Interpro (EBI) | Kinase-like_dom Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_kinase_AS |
| Domain families : Pfam (Sanger) | Pkinase (PF00069) |
| Domain families : Pfam (NCBI) | pfam00069 |
| Domain families : Smart (EMBL) | S_TKc (SM00220) |
| Conserved Domain (NCBI) | CDK1 |
| DMDM Disease mutations | 983 |
| Blocks (Seattle) | CDK1 |
| PDB (SRS) | 1LC9 4Y72 4YC3 4YC6 5HQ0 5LQF |
| PDB (PDBSum) | 1LC9 4Y72 4YC3 4YC6 5HQ0 5LQF |
| PDB (IMB) | 1LC9 4Y72 4YC3 4YC6 5HQ0 5LQF |
| PDB (RSDB) | 1LC9 4Y72 4YC3 4YC6 5HQ0 5LQF |
| Structural Biology KnowledgeBase | 1LC9 4Y72 4YC3 4YC6 5HQ0 5LQF |
| SCOP (Structural Classification of Proteins) | 1LC9 4Y72 4YC3 4YC6 5HQ0 5LQF |
| CATH (Classification of proteins structures) | 1LC9 4Y72 4YC3 4YC6 5HQ0 5LQF |
| Superfamily | P06493 |
| Human Protein Atlas [tissue] | ENSG00000170312-CDK1 [tissue] |
| Peptide Atlas | P06493 |
| HPRD | 00302 |
| IPI | IPI00073536 IPI00026689 IPI00954937 IPI01017942 IPI00985068 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P06493 |
| IntAct (EBI) | P06493 |
| FunCoup | ENSG00000170312 |
| BioGRID | CDK1 |
| STRING (EMBL) | CDK1 |
| ZODIAC | CDK1 |
| Ontologies - Pathways |
|---|
| QuickGO | P06493 |
| Ontology : AmiGO | G2/M transition of mitotic cell cycle activation of MAPK activity microtubule cytoskeleton organization cyclin-dependent protein kinase holoenzyme complex nuclear chromosome, telomeric region virus receptor activity chromatin binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm mitochondrion mitochondrial matrix endoplasmic reticulum membrane centrosome cytosol cytosol spindle microtubule DNA replication DNA repair transcription initiation from RNA polymerase II promoter protein complex assembly protein phosphorylation apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest mitotic nuclear envelope disassembly mitotic G2 DNA damage checkpoint centrosome cycle pronuclear fusion cell aging cell proliferation RNA polymerase II carboxy-terminal domain kinase activity regulation of G2/M transition of mitotic cell cycle regulation of gene expression positive regulation of gene expression positive regulation of G2/M transition of mitotic cell cycle regulation of Schwann cell differentiation response to organic cyclic compound response to amine response to activity membrane cell migration histone phosphorylation protein deubiquitination peptidyl-serine phosphorylation peptidyl-threonine phosphorylation chromosome condensation cyclin binding cyclin binding midbody Hsp70 protein binding epithelial cell differentiation animal organ regeneration anaphase-promoting complex-dependent catabolic process positive regulation of protein import into nucleus, translocation protein localization to kinetochore histone kinase activity protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process response to ethanol positive regulation of DNA replication regulation of embryonic development response to cadmium ion response to copper ion viral entry into host cell response to axon injury cell division negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle regulation of meiotic cell cycle ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation extracellular exosome cellular response to hydrogen peroxide mitotic spindle Golgi disassembly cyclin B1-CDK1 complex cyclin-dependent protein kinase activity ciliary basal body-plasma membrane docking positive regulation of protein localization to nucleus positive regulation of mitochondrial ATP synthesis coupled electron transport |
| Ontology : EGO-EBI | G2/M transition of mitotic cell cycle activation of MAPK activity microtubule cytoskeleton organization cyclin-dependent protein kinase holoenzyme complex nuclear chromosome, telomeric region virus receptor activity chromatin binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm mitochondrion mitochondrial matrix endoplasmic reticulum membrane centrosome cytosol cytosol spindle microtubule DNA replication DNA repair transcription initiation from RNA polymerase II promoter protein complex assembly protein phosphorylation apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest mitotic nuclear envelope disassembly mitotic G2 DNA damage checkpoint centrosome cycle pronuclear fusion cell aging cell proliferation RNA polymerase II carboxy-terminal domain kinase activity regulation of G2/M transition of mitotic cell cycle regulation of gene expression positive regulation of gene expression positive regulation of G2/M transition of mitotic cell cycle regulation of Schwann cell differentiation response to organic cyclic compound response to amine response to activity membrane cell migration histone phosphorylation protein deubiquitination peptidyl-serine phosphorylation peptidyl-threonine phosphorylation chromosome condensation cyclin binding cyclin binding midbody Hsp70 protein binding epithelial cell differentiation animal organ regeneration anaphase-promoting complex-dependent catabolic process positive regulation of protein import into nucleus, translocation protein localization to kinetochore histone kinase activity protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process response to ethanol positive regulation of DNA replication regulation of embryonic development response to cadmium ion response to copper ion viral entry into host cell response to axon injury cell division negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle regulation of meiotic cell cycle ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation extracellular exosome cellular response to hydrogen peroxide mitotic spindle Golgi disassembly cyclin B1-CDK1 complex cyclin-dependent protein kinase activity ciliary basal body-plasma membrane docking positive regulation of protein localization to nucleus positive regulation of mitochondrial ATP synthesis coupled electron transport |
| Pathways : BIOCARTA | Cell Cycle: G2/M Checkpoint [Genes] Regulation of Splicing through Sam68 [Genes] How Progesterone Initiates the Oocyte Maturation [Genes] Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle [Genes] AKAP95 role in mitosis and chromosome dynamics [Genes] Cyclins and Cell Cycle Regulation [Genes] Activation of Src by Protein-tyrosine phosphatase alpha [Genes] Stathmin and breast cancer resistance to antimicrotubule agents [Genes] cdc25 and chk1 Regulatory Pathway in response to DNA damage [Genes] RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage [Genes] Cell Cycle: G1/S Check Point [Genes] Protein Kinase A at the Centrosome [Genes] Estrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes] |
| Pathways : KEGG | Gap junction Cell cycle |
| NDEx Network | CDK1 |
| Atlas of Cancer Signalling Network | CDK1 |
| Wikipedia pathways | CDK1 |
| Orthology - Evolution |
|---|
| OrthoDB | 983 |
| GeneTree (enSembl) | ENSG00000170312 |
| Phylogenetic Trees/Animal Genes : TreeFam | CDK1 |
| HOVERGEN | P06493 |
| HOGENOM | P06493 |
| Homologs : HomoloGene | CDK1 |
| Homology/Alignments : Family Browser (UCSC) | CDK1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | ANK3/CDK1 [10q21.2/10q21.2] [t(10;10)(q21;q21)] |
| Fusion : Mitelman | CDK1/USP24 [10q21.2/1p32.3] [t(1;10)(p32;q21)] |
| Fusion : Mitelman | MCOLN2/CDK1 [1p22.3/10q21.2] [t(1;10)(p22;q21)] |
| Fusion Portal | ANK3 10q21.2 CDK1 10q21.2 BRCA |
| Fusion Portal | MCOLN2 1p22.3 CDK1 10q21.2 LUAD |
| Fusion : Quiver | CDK1 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CDK1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CDK1 |
| dbVar | CDK1 |
| ClinVar | CDK1 |
| 1000_Genomes | CDK1 |
| Exome Variant Server | CDK1 |
| ExAC (Exome Aggregation Consortium) | ENSG00000170312 |
| GNOMAD Browser | ENSG00000170312 |
| Genetic variants : HAPMAP | 983 |
| Genomic Variants (DGV) | CDK1 [DGVbeta] |
| DECIPHER | CDK1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CDK1 |
| Mutations |
|---|
| ICGC Data Portal | CDK1 |
| TCGA Data Portal | CDK1 |
| Broad Tumor Portal | CDK1 |
| OASIS Portal | CDK1 [ Somatic mutations - Copy number] |
| Mutations and Diseases : HGMD | CDK1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CDK1 |
| DgiDB (Drug Gene Interaction Database) | CDK1 |
| DoCM (Curated mutations) | CDK1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CDK1 (select a term) |
| intoGen | CDK1 |
| Cancer3D | CDK1(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 116940 |
| Orphanet | |
| DisGeNET | CDK1 |
| Medgen | CDK1 |
| Genetic Testing Registry | CDK1
|
| NextProt | P06493 [Medical] |
| TSGene | 983 |
| GENETests | CDK1 |
| Target Validation | CDK1 |
| Huge Navigator |
CDK1 [HugePedia] |
| snp3D : Map Gene to Disease | 983 |
| BioCentury BCIQ | CDK1 |
| ClinGen | CDK1 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 983 |
| Chemical/Pharm GKB Gene | PA99 |
| Clinical trial | CDK1 |
| Miscellaneous |
|---|
| canSAR (ICR) | CDK1 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | CDK1 |
| EVEX | CDK1 |
| GoPubMed | CDK1 |
| iHOP | CDK1 |
