Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CDK1 (cyclin dependent kinase 1)

Identity

Alias (NCBI)CDC2
CDC28A
P34CDC2
HGNC (Hugo) CDK1
HGNC Alias symbCDC28A
HGNC Previous nameCDC2
HGNC Previous namecell division cycle 2, G1 to S and G2 to M
LocusID (NCBI) 983
Atlas_Id 51245
Location 10q21.2  [Link to chromosome band 10q21]
Location_base_pair Starts at 60778454 and ends at 60794852 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANK3 (10q21.2) / CDK1 (10q21.2)BASP1 (5p15.1) / CDK1 (10q21.2)CDK1 (10q21.2) / USP24 (1p32.3)
MCOLN2 (1p22.3) / CDK1 (10q21.2)ANK3 10q21.2 / CDK1 10q21.2MCOLN2 1p22.3 / CDK1 10q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;13)(q21;q14) CDK1/DGKH

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(1;10)(p22;q21) MCOLN2/CDK1
t(1;10)(p32;q21) CDK1/USP24
ANK3/CDK1 (10q21)

External links

Nomenclature
HGNC (Hugo)CDK1   1722
Cards
Entrez_Gene (NCBI)CDK1  983  cyclin dependent kinase 1
AliasesCDC2; CDC28A; P34CDC2
GeneCards (Weizmann)CDK1
Ensembl hg19 (Hinxton)ENSG00000170312 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170312 [Gene_View]  ENSG00000170312 [Sequence]  chr10:60778454-60794852 [Contig_View]  CDK1 [Vega]
ICGC DataPortalENSG00000170312
TCGA cBioPortalCDK1
AceView (NCBI)CDK1
Genatlas (Paris)CDK1
WikiGenes983
SOURCE (Princeton)CDK1
Genetics Home Reference (NIH)CDK1
Genomic and cartography
GoldenPath hg38 (UCSC)CDK1  -     chr10:60778454-60794852 +  10q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK1  -     10q21.2   [Description]    (hg19-Feb_2009)
GoldenPathCDK1 - 10q21.2 [CytoView hg19]  CDK1 - 10q21.2 [CytoView hg38]
ImmunoBaseENSG00000170312
genome Data Viewer NCBICDK1 [Mapview hg19]  
OMIM116940   
Gene and transcription
Genbank (Entrez)AA459484 AK291939 AK295741 AW976143 BC014563
RefSeq transcript (Entrez)NM_001130829 NM_001170406 NM_001170407 NM_001320918 NM_001786 NM_033379
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK1
Alternative Splicing GalleryENSG00000170312
Gene ExpressionCDK1 [ NCBI-GEO ]   CDK1 [ EBI - ARRAY_EXPRESS ]   CDK1 [ SEEK ]   CDK1 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK1 [ Firebrowse - Broad ]
GenevisibleExpression of CDK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)983
GTEX Portal (Tissue expression)CDK1
Human Protein AtlasENSG00000170312-CDK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06493   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06493  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06493
Splice isoforms : SwissVarP06493
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP06493
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK1
DMDM Disease mutations983
Blocks (Seattle)CDK1
PDB (RSDB)1LC9    4Y72    4YC3    4YC6    5HQ0    5LQF    6GU2    6GU3    6GU4    6GU6    6GU7   
PDB Europe1LC9    4Y72    4YC3    4YC6    5HQ0    5LQF    6GU2    6GU3    6GU4    6GU6    6GU7   
PDB (PDBSum)1LC9    4Y72    4YC3    4YC6    5HQ0    5LQF    6GU2    6GU3    6GU4    6GU6    6GU7   
PDB (IMB)1LC9    4Y72    4YC3    4YC6    5HQ0    5LQF    6GU2    6GU3    6GU4    6GU6    6GU7   
Structural Biology KnowledgeBase1LC9    4Y72    4YC3    4YC6    5HQ0    5LQF    6GU2    6GU3    6GU4    6GU6    6GU7   
SCOP (Structural Classification of Proteins)1LC9    4Y72    4YC3    4YC6    5HQ0    5LQF    6GU2    6GU3    6GU4    6GU6    6GU7   
CATH (Classification of proteins structures)1LC9    4Y72    4YC3    4YC6    5HQ0    5LQF    6GU2    6GU3    6GU4    6GU6    6GU7   
SuperfamilyP06493
Human Protein Atlas [tissue]ENSG00000170312-CDK1 [tissue]
Peptide AtlasP06493
HPRD00302
IPIIPI00073536   IPI00026689   IPI00954937   IPI01017942   IPI00985068   
Protein Interaction databases
DIP (DOE-UCLA)P06493
IntAct (EBI)P06493
FunCoupENSG00000170312
BioGRIDCDK1
STRING (EMBL)CDK1
ZODIACCDK1
Ontologies - Pathways
QuickGOP06493
Ontology : AmiGOG2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  activation of MAPK activity  microtubule cytoskeleton organization  cyclin-dependent protein kinase holoenzyme complex  nuclear chromosome, telomeric region  virus receptor activity  chromatin binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  mitochondrial matrix  endoplasmic reticulum membrane  centrosome  cytosol  cytosol  spindle microtubule  DNA replication  DNA repair  transcription initiation from RNA polymerase II promoter  protein phosphorylation  protein phosphorylation  protein phosphorylation  apoptotic process  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  mitotic nuclear envelope disassembly  mitotic G2 DNA damage checkpoint  centrosome cycle  pronuclear fusion  cell aging  cell proliferation  RNA polymerase II CTD heptapeptide repeat kinase activity  RNA polymerase II CTD heptapeptide repeat kinase activity  regulation of G2/M transition of mitotic cell cycle  positive regulation of gene expression  positive regulation of G2/M transition of mitotic cell cycle  regulation of Schwann cell differentiation  response to organic cyclic compound  response to amine  response to activity  membrane  cell migration  histone phosphorylation  protein deubiquitination  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-threonine phosphorylation  chromosome condensation  cyclin binding  cyclin binding  midbody  Hsp70 protein binding  epithelial cell differentiation  animal organ regeneration  anaphase-promoting complex-dependent catabolic process  protein localization to kinetochore  histone kinase activity  positive regulation of protein import into nucleus  regulation of circadian rhythm  negative regulation of apoptotic process  response to ethanol  positive regulation of DNA replication  regulation of embryonic development  response to cadmium ion  response to copper ion  viral entry into host cell  rhythmic process  response to axon injury  cell division  ventricular cardiac muscle cell development  positive regulation of cardiac muscle cell proliferation  protein-containing complex assembly  extracellular exosome  cellular response to hydrogen peroxide  mitotic spindle  Golgi disassembly  cyclin B1-CDK1 complex  cyclin-dependent protein kinase activity  ciliary basal body-plasma membrane docking  positive regulation of protein localization to nucleus  regulation of mitotic cell cycle phase transition  positive regulation of mitochondrial ATP synthesis coupled electron transport  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  activation of MAPK activity  microtubule cytoskeleton organization  cyclin-dependent protein kinase holoenzyme complex  nuclear chromosome, telomeric region  virus receptor activity  chromatin binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  mitochondrial matrix  endoplasmic reticulum membrane  centrosome  cytosol  cytosol  spindle microtubule  DNA replication  DNA repair  transcription initiation from RNA polymerase II promoter  protein phosphorylation  protein phosphorylation  protein phosphorylation  apoptotic process  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  mitotic nuclear envelope disassembly  mitotic G2 DNA damage checkpoint  centrosome cycle  pronuclear fusion  cell aging  cell proliferation  RNA polymerase II CTD heptapeptide repeat kinase activity  RNA polymerase II CTD heptapeptide repeat kinase activity  regulation of G2/M transition of mitotic cell cycle  positive regulation of gene expression  positive regulation of G2/M transition of mitotic cell cycle  regulation of Schwann cell differentiation  response to organic cyclic compound  response to amine  response to activity  membrane  cell migration  histone phosphorylation  protein deubiquitination  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-threonine phosphorylation  chromosome condensation  cyclin binding  cyclin binding  midbody  Hsp70 protein binding  epithelial cell differentiation  animal organ regeneration  anaphase-promoting complex-dependent catabolic process  protein localization to kinetochore  histone kinase activity  positive regulation of protein import into nucleus  regulation of circadian rhythm  negative regulation of apoptotic process  response to ethanol  positive regulation of DNA replication  regulation of embryonic development  response to cadmium ion  response to copper ion  viral entry into host cell  rhythmic process  response to axon injury  cell division  ventricular cardiac muscle cell development  positive regulation of cardiac muscle cell proliferation  protein-containing complex assembly  extracellular exosome  cellular response to hydrogen peroxide  mitotic spindle  Golgi disassembly  cyclin B1-CDK1 complex  cyclin-dependent protein kinase activity  ciliary basal body-plasma membrane docking  positive regulation of protein localization to nucleus  regulation of mitotic cell cycle phase transition  positive regulation of mitochondrial ATP synthesis coupled electron transport  
Pathways : KEGGCell cycle    Oocyte meiosis    p53 signaling pathway    Gap junction    Progesterone-mediated oocyte maturation    Herpes simplex infection    Epstein-Barr virus infection    Viral carcinogenesis   
NDEx NetworkCDK1
Atlas of Cancer Signalling NetworkCDK1
Wikipedia pathwaysCDK1
Orthology - Evolution
OrthoDB983
GeneTree (enSembl)ENSG00000170312
Phylogenetic Trees/Animal Genes : TreeFamCDK1
HOGENOMP06493
Homologs : HomoloGeneCDK1
Homology/Alignments : Family Browser (UCSC)CDK1
Gene fusions - Rearrangements
Fusion : MitelmanANK3/CDK1 [10q21.2/10q21.2]  
Fusion : MitelmanCDK1/USP24 [10q21.2/1p32.3]  
Fusion : MitelmanMCOLN2/CDK1 [1p22.3/10q21.2]  
Fusion PortalANK3 10q21.2 CDK1 10q21.2 BRCA
Fusion PortalMCOLN2 1p22.3 CDK1 10q21.2 LUAD
Fusion : QuiverCDK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK1
dbVarCDK1
ClinVarCDK1
MonarchCDK1
1000_GenomesCDK1 
Exome Variant ServerCDK1
GNOMAD BrowserENSG00000170312
Varsome BrowserCDK1
Genetic variants : HAPMAP983
Genomic Variants (DGV)CDK1 [DGVbeta]
DECIPHERCDK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK1 
Mutations
ICGC Data PortalCDK1 
TCGA Data PortalCDK1 
Broad Tumor PortalCDK1
OASIS PortalCDK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDK1
Mutations and Diseases : HGMDCDK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK1
DgiDB (Drug Gene Interaction Database)CDK1
DoCM (Curated mutations)CDK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK1 (select a term)
intoGenCDK1
Cancer3DCDK1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM116940   
Orphanet
DisGeNETCDK1
MedgenCDK1
Genetic Testing Registry CDK1
NextProtP06493 [Medical]
TSGene983
GENETestsCDK1
Target ValidationCDK1
Huge Navigator CDK1 [HugePedia]
snp3D : Map Gene to Disease983
BioCentury BCIQCDK1
ClinGenCDK1
Clinical trials, drugs, therapy
Protein Interactions : CTD983
Pharm GKB GenePA99
Clinical trialCDK1
Miscellaneous
canSAR (ICR)CDK1 (select the gene name)
HarmonizomeCDK1
DataMed IndexCDK1
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK1
EVEXCDK1
GoPubMedCDK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:05:21 CEST 2020
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