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CDK10 (cyclin-dependent kinase 10)

Identity

Alias_namescyclin-dependent kinase (CDC2-like) 10
Alias_symbol (synonym)PISSLRE
Other alias
HGNC (Hugo) CDK10
LocusID (NCBI) 8558
Atlas_Id 40030
Location 16q24.3  [Link to chromosome band 16q24]
Location_base_pair Starts at 89753076 and ends at 89762772 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDK10 (16q24.3) / MDS2 (1p36.11)CDK10 (16q24.3) / SPATA33 (16q24.3)CDK10 16q24.3 C16orf55

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK10   1770
Cards
Entrez_Gene (NCBI)CDK10  8558  cyclin-dependent kinase 10
AliasesPISSLRE
GeneCards (Weizmann)CDK10
Ensembl hg19 (Hinxton)ENSG00000185324 [Gene_View]  chr16:89753076-89762772 [Contig_View]  CDK10 [Vega]
Ensembl hg38 (Hinxton)ENSG00000185324 [Gene_View]  chr16:89753076-89762772 [Contig_View]  CDK10 [Vega]
ICGC DataPortalENSG00000185324
TCGA cBioPortalCDK10
AceView (NCBI)CDK10
Genatlas (Paris)CDK10
WikiGenes8558
SOURCE (Princeton)CDK10
Genetics Home Reference (NIH)CDK10
Genomic and cartography
GoldenPath hg19 (UCSC)CDK10  -     chr16:89753076-89762772 +  16q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CDK10  -     16q24.3   [Description]    (hg38-Dec_2013)
EnsemblCDK10 - 16q24.3 [CytoView hg19]  CDK10 - 16q24.3 [CytoView hg38]
Mapping of homologs : NCBICDK10 [Mapview hg19]  CDK10 [Mapview hg38]
OMIM603464   
Gene and transcription
Genbank (Entrez)AB209829 AF153430 AK075036 AK131531 AK290485
RefSeq transcript (Entrez)NM_001098533 NM_001160367 NM_003674 NM_052987 NM_052988
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010498 NW_004929403
Consensus coding sequences : CCDS (NCBI)CDK10
Cluster EST : UnigeneHs.699177 [ NCBI ]
CGAP (NCI)Hs.699177
Alternative Splicing GalleryENSG00000185324
Gene ExpressionCDK10 [ NCBI-GEO ]   CDK10 [ EBI - ARRAY_EXPRESS ]   CDK10 [ SEEK ]   CDK10 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8558
GTEX Portal (Tissue expression)CDK10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15131   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15131  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15131
Splice isoforms : SwissVarQ15131
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusQ15131
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK10
DMDM Disease mutations8558
Blocks (Seattle)CDK10
SuperfamilyQ15131
Human Protein AtlasENSG00000185324
Peptide AtlasQ15131
IPIIPI00642595   IPI00395448   IPI00014873   IPI00788960   IPI00556339   IPI00969212   IPI01015440   IPI00965643   IPI00020336   IPI00966313   
Protein Interaction databases
DIP (DOE-UCLA)Q15131
IntAct (EBI)Q15131
FunCoupENSG00000185324
BioGRIDCDK10
STRING (EMBL)CDK10
ZODIACCDK10
Ontologies - Pathways
QuickGOQ15131
Ontology : AmiGOcyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  protein phosphorylation  traversing start control point of mitotic cell cycle  negative regulation of cell proliferation  positive regulation of MAPK cascade  
Ontology : EGO-EBIcyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  protein phosphorylation  traversing start control point of mitotic cell cycle  negative regulation of cell proliferation  positive regulation of MAPK cascade  
NDEx NetworkCDK10
Atlas of Cancer Signalling NetworkCDK10
Wikipedia pathwaysCDK10
Orthology - Evolution
OrthoDB8558
GeneTree (enSembl)ENSG00000185324
Phylogenetic Trees/Animal Genes : TreeFamCDK10
HOVERGENQ15131
HOGENOMQ15131
Homologs : HomoloGeneCDK10
Homology/Alignments : Family Browser (UCSC)CDK10
Gene fusions - Rearrangements
Fusion : MitelmanCDK10/SPATA33 [16q24.3/16q24.3]  
Fusion: TCGACDK10 16q24.3 C16orf55 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK10
dbVarCDK10
ClinVarCDK10
1000_GenomesCDK10 
Exome Variant ServerCDK10
ExAC (Exome Aggregation Consortium)CDK10 (select the gene name)
Genetic variants : HAPMAP8558
Genomic Variants (DGV)CDK10 [DGVbeta]
DECIPHER (Syndromes)16:89753076-89762772  ENSG00000185324
CONAN: Copy Number AnalysisCDK10 
Mutations
ICGC Data PortalCDK10 
TCGA Data PortalCDK10 
Broad Tumor PortalCDK10
OASIS PortalCDK10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK10
DgiDB (Drug Gene Interaction Database)CDK10
DoCM (Curated mutations)CDK10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK10 (select a term)
intoGenCDK10
Cancer3DCDK10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603464   
Orphanet
MedgenCDK10
Genetic Testing Registry CDK10
NextProtQ15131 [Medical]
TSGene8558
GENETestsCDK10
Huge Navigator CDK10 [HugePedia]
snp3D : Map Gene to Disease8558
BioCentury BCIQCDK10
ClinGenCDK10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8558
Chemical/Pharm GKB GenePA26307
Clinical trialCDK10
Miscellaneous
canSAR (ICR)CDK10 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK10
EVEXCDK10
GoPubMedCDK10
iHOPCDK10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:59:42 CET 2017

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