CDK11A (cyclin dependent kinase 11A)

2010-01-01  

Identity

HGNC
LOCATION
1p36.33
LOCUSID
ALIAS
CDC2L2,CDC2L3,CDK11-p110,CDK11-p46,CDK11-p58,PITSLRE,p58GTA
FUSION GENES

Other Information

Locus ID:

NCBI: 728642
MIM: 116951
HGNC: 1730
Ensembl: ENSG00000008128

Variants:

dbSNP: 728642
ClinVar: 728642
TCGA: ENSG00000008128
COSMIC: CDK11A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008128ENST00000356200Q5QPR4
ENSG00000008128ENST00000357760Q5QPR3
ENSG00000008128ENST00000358779Q9UQ88
ENSG00000008128ENST00000378633Q9UQ88
ENSG00000008128ENST00000378638Q5QPR4
ENSG00000008128ENST00000401096Q5QPQ9
ENSG00000008128ENST00000404249Q9UQ88
ENSG00000008128ENST00000460465J3KS35
ENSG00000008128ENST00000479362E9PFJ2
ENSG00000008128ENST00000509982E7ESP2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
153307582005Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.40
192458112009Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.26
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.16
145116412003The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM.15
270497272016The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer.12
191222082009Repression of estrogen receptor alpha by CDK11p58 through promoting its ubiquitin-proteasome degradation.8
195207722009CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression.6
160396072005The cyclin-dependent kinase 11 interacts with NOT2.4
307227252019CDK11p110 plays a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells and is a potential drug target.2
158830432005The cyclin-dependent kinase 11 interacts with 14-3-3 proteins.0

Citation

Dessen P

CDK11A (cyclin dependent kinase 11A)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51286/cdk11a