Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CDK11A (cyclin dependent kinase 11A)

Identity

Alias_namesCDC2L3
CDC2L2
cell division cycle 2-like 2
cell division cycle 2-like 2 (PITSLRE proteins)
Alias_symbol (synonym)PITSLRE
CDK11-p110
CDK11-p58
CDK11-p46
p58GTA
Other alias
HGNC (Hugo) CDK11A
LocusID (NCBI) 728642
Atlas_Id 51286
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1702384 and ends at 1724565 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SLC35E2B (1p36.33) / CDK11A (1p36.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK11A   1730
Cards
Entrez_Gene (NCBI)CDK11A  728642  cyclin dependent kinase 11A
AliasesCDC2L2; CDC2L3; CDK11-p110; CDK11-p46; 
CDK11-p58; PITSLRE; p58GTA
GeneCards (Weizmann)CDK11A
Ensembl hg19 (Hinxton)ENSG00000008128 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008128 [Gene_View]  chr1:1702384-1724565 [Contig_View]  CDK11A [Vega]
ICGC DataPortalENSG00000008128
TCGA cBioPortalCDK11A
AceView (NCBI)CDK11A
Genatlas (Paris)CDK11A
WikiGenes728642
SOURCE (Princeton)CDK11A
Genetics Home Reference (NIH)CDK11A
Genomic and cartography
GoldenPath hg38 (UCSC)CDK11A  -     chr1:1702384-1724565 -  1p36.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK11A  -     1p36.33   [Description]    (hg19-Feb_2009)
EnsemblCDK11A - 1p36.33 [CytoView hg19]  CDK11A - 1p36.33 [CytoView hg38]
Mapping of homologs : NCBICDK11A [Mapview hg19]  CDK11A [Mapview hg38]
OMIM116951   
Gene and transcription
Genbank (Entrez)AF067518 AF067519 AF067520 AF067521 AF067522
RefSeq transcript (Entrez)NM_001313896 NM_001313982 NM_024011 NM_033527 NM_033529 NM_033532 NM_033534
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK11A
Cluster EST : UnigeneHs.709182 [ NCBI ]
CGAP (NCI)Hs.709182
Alternative Splicing GalleryENSG00000008128
Gene ExpressionCDK11A [ NCBI-GEO ]   CDK11A [ EBI - ARRAY_EXPRESS ]   CDK11A [ SEEK ]   CDK11A [ MEM ]
Gene Expression Viewer (FireBrowse)CDK11A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)728642
GTEX Portal (Tissue expression)CDK11A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UQ88   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UQ88  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UQ88
Splice isoforms : SwissVarQ9UQ88
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusQ9UQ88
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK11A
DMDM Disease mutations728642
Blocks (Seattle)CDK11A
SuperfamilyQ9UQ88
Human Protein AtlasENSG00000008128
Peptide AtlasQ9UQ88
IPIIPI00099746   IPI00070809   IPI00219508   IPI00334381   IPI00024414   IPI00024413   IPI00294006   IPI00956665   IPI00954798   IPI00954975   IPI00556426   IPI00981599   IPI00954810   IPI00954484   IPI01009825   IPI00966223   
Protein Interaction databases
DIP (DOE-UCLA)Q9UQ88
IntAct (EBI)Q9UQ88
FunCoupENSG00000008128
BioGRIDCDK11A
STRING (EMBL)CDK11A
ZODIACCDK11A
Ontologies - Pathways
QuickGOQ9UQ88
Ontology : AmiGOmitotic cell cycle  regulation of cell growth  protein kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  regulation of mitotic cell cycle  regulation of mRNA processing  
Ontology : EGO-EBImitotic cell cycle  regulation of cell growth  protein kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  regulation of mitotic cell cycle  regulation of mRNA processing  
Pathways : BIOCARTAHIV-I Nef: negative effector of Fas and TNF [Genes]   
NDEx NetworkCDK11A
Atlas of Cancer Signalling NetworkCDK11A
Wikipedia pathwaysCDK11A
Orthology - Evolution
OrthoDB728642
GeneTree (enSembl)ENSG00000008128
Phylogenetic Trees/Animal Genes : TreeFamCDK11A
HOVERGENQ9UQ88
HOGENOMQ9UQ88
Homologs : HomoloGeneCDK11A
Homology/Alignments : Family Browser (UCSC)CDK11A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK11A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK11A
dbVarCDK11A
ClinVarCDK11A
1000_GenomesCDK11A 
Exome Variant ServerCDK11A
ExAC (Exome Aggregation Consortium)CDK11A (select the gene name)
Genetic variants : HAPMAP728642
Genomic Variants (DGV)CDK11A [DGVbeta]
DECIPHERCDK11A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK11A 
Mutations
ICGC Data PortalCDK11A 
TCGA Data PortalCDK11A 
Broad Tumor PortalCDK11A
OASIS PortalCDK11A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK11A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK11A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK11A
DgiDB (Drug Gene Interaction Database)CDK11A
DoCM (Curated mutations)CDK11A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK11A (select a term)
intoGenCDK11A
Cancer3DCDK11A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM116951   
Orphanet
MedgenCDK11A
Genetic Testing Registry CDK11A
NextProtQ9UQ88 [Medical]
TSGene728642
GENETestsCDK11A
Target ValidationCDK11A
Huge Navigator CDK11A [HugePedia]
snp3D : Map Gene to Disease728642
BioCentury BCIQCDK11A
ClinGenCDK11A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD728642
Chemical/Pharm GKB GenePA26263
Clinical trialCDK11A
Miscellaneous
canSAR (ICR)CDK11A (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK11A
EVEXCDK11A
GoPubMedCDK11A
iHOPCDK11A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:27:43 CEST 2017

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