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CDK11B (cyclin dependent kinase 11B)

Identity

Alias_namesCDC2L1
cell division cycle 2-like 1 (PITSLRE proteins)
Alias_symbol (synonym)CDK11-p110
CDK11-p58
CDK11-p46
Other aliasCDK11
CLK-1
PITSLREA
PK58
p58
p58CDC2L1
p58CLK-1
HGNC (Hugo) CDK11B
LocusID (NCBI) 984
Atlas_Id 40008
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1635226 and ends at 1659097 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDK11B (1p36.33) / DBI (2q14.2)CDK11B (1p36.33) / FZR1 (19p13.3)CDK11B (1p36.33) / NDUFA12 (12q22)
CDK11B (1p36.33) / SLC35E2 (1p36.33)IL1RN (2q13) / CDK11B (1p36.33)KRT5 (12q13.13) / CDK11B (1p36.33)
PCBP2 (12q13.13) / CDK11B (1p36.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Skin: Melanoma


External links

Nomenclature
HGNC (Hugo)CDK11B   1729
Cards
Entrez_Gene (NCBI)CDK11B  984  cyclin dependent kinase 11B
AliasesCDC2L1; CDK11; CDK11-p110; CDK11-p46; 
CDK11-p58; CLK-1; PITSLREA; PK58; p58; p58CDC2L1; p58CLK-1
GeneCards (Weizmann)CDK11B
Ensembl hg19 (Hinxton)ENSG00000248333 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000248333 [Gene_View]  chr1:1635226-1659097 [Contig_View]  CDK11B [Vega]
ICGC DataPortalENSG00000248333
TCGA cBioPortalCDK11B
AceView (NCBI)CDK11B
Genatlas (Paris)CDK11B
WikiGenes984
SOURCE (Princeton)CDK11B
Genetics Home Reference (NIH)CDK11B
Genomic and cartography
GoldenPath hg38 (UCSC)CDK11B  -     chr1:1635226-1659097 -  1p36.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK11B  -     1p36.33   [Description]    (hg19-Feb_2009)
EnsemblCDK11B - 1p36.33 [CytoView hg19]  CDK11B - 1p36.33 [CytoView hg38]
Mapping of homologs : NCBICDK11B [Mapview hg19]  CDK11B [Mapview hg38]
OMIM176873   
Gene and transcription
Genbank (Entrez)AA778148 AF067512 AF067513 AF067514 AF067515
RefSeq transcript (Entrez)NM_001291345 NM_001787 NM_033486 NM_033487 NM_033488 NM_033489 NM_033490 NM_033492 NM_033493
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK11B
Cluster EST : UnigeneHs.709182 [ NCBI ]
CGAP (NCI)Hs.709182
Alternative Splicing GalleryENSG00000248333
Gene ExpressionCDK11B [ NCBI-GEO ]   CDK11B [ EBI - ARRAY_EXPRESS ]   CDK11B [ SEEK ]   CDK11B [ MEM ]
Gene Expression Viewer (FireBrowse)CDK11B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)984
GTEX Portal (Tissue expression)CDK11B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21127   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21127  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21127
Splice isoforms : SwissVarP21127
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusP21127
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK11B
DMDM Disease mutations984
Blocks (Seattle)CDK11B
SuperfamilyP21127
Human Protein AtlasENSG00000248333
Peptide AtlasP21127
HPRD08909
IPIIPI00215999   IPI00736011   IPI00759690   IPI00071185   IPI00376979   IPI00376980   IPI00337617   IPI00395687   IPI00376983   IPI00071188   
Protein Interaction databases
DIP (DOE-UCLA)P21127
IntAct (EBI)P21127
FunCoupENSG00000248333
BioGRIDCDK11B
STRING (EMBL)CDK11B
ZODIACCDK11B
Ontologies - Pathways
QuickGOP21127
Ontology : AmiGOmitotic cell cycle  regulation of cell growth  RNA binding  protein kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  regulation of mitotic cell cycle  cell proliferation  regulation of mRNA processing  
Ontology : EGO-EBImitotic cell cycle  regulation of cell growth  RNA binding  protein kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  regulation of mitotic cell cycle  cell proliferation  regulation of mRNA processing  
Pathways : BIOCARTAHIV-I Nef: negative effector of Fas and TNF [Genes]   
NDEx NetworkCDK11B
Atlas of Cancer Signalling NetworkCDK11B
Wikipedia pathwaysCDK11B
Orthology - Evolution
OrthoDB984
GeneTree (enSembl)ENSG00000248333
Phylogenetic Trees/Animal Genes : TreeFamCDK11B
HOVERGENP21127
HOGENOMP21127
Homologs : HomoloGeneCDK11B
Homology/Alignments : Family Browser (UCSC)CDK11B
Gene fusions - Rearrangements
Fusion : MitelmanCDK11B/SLC35E2 [1p36.33/1p36.33]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK11B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK11B
dbVarCDK11B
ClinVarCDK11B
1000_GenomesCDK11B 
Exome Variant ServerCDK11B
ExAC (Exome Aggregation Consortium)CDK11B (select the gene name)
Genetic variants : HAPMAP984
Genomic Variants (DGV)CDK11B [DGVbeta]
DECIPHERCDK11B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK11B 
Mutations
ICGC Data PortalCDK11B 
TCGA Data PortalCDK11B 
Broad Tumor PortalCDK11B
OASIS PortalCDK11B [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCDK11B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK11B
DgiDB (Drug Gene Interaction Database)CDK11B
DoCM (Curated mutations)CDK11B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK11B (select a term)
intoGenCDK11B
Cancer3DCDK11B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176873   
Orphanet
MedgenCDK11B
Genetic Testing Registry CDK11B
NextProtP21127 [Medical]
TSGene984
GENETestsCDK11B
Target ValidationCDK11B
Huge Navigator CDK11B [HugePedia]
snp3D : Map Gene to Disease984
BioCentury BCIQCDK11B
ClinGenCDK11B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD984
Chemical/Pharm GKB GenePA26262
Clinical trialCDK11B
Miscellaneous
canSAR (ICR)CDK11B (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK11B
EVEXCDK11B
GoPubMedCDK11B
iHOPCDK11B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:27:44 CEST 2017

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