Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CDK12 (cyclin dependent kinase 12)

Identity

Alias_namesCRKRS
Cdc2-related kinase, arginine/serine-rich
Alias_symbol (synonym)CRK7
CRKR
KIAA0904
Other alias
HGNC (Hugo) CDK12
LocusID (NCBI) 51755
Atlas_Id 51267
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 39461511 and ends at 39534565 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDK12 (17q12) / AKAP1 (17q22)CDK12 (17q12) / CDK12 (17q12)CDK12 (17q12) / EIF4A3 (17q25.3)
CDK12 (17q12) / FBXL20 (17q12)CDK12 (17q12) / JAK2 (9p24.1)CDK12 (17q12) / SMG6 (17p13.3)
CYP19A1 (15q21.2) / CDK12 (17q12)ERBB2 (17q12) / CDK12 (17q12)FBXL20 (17q12) / CDK12 (17q12)
MED1 (17q12) / CDK12 (17q12)MSL1 (17q21.1) / CDK12 (17q12)PDK2 (17q21.33) / CDK12 (17q12)
PSMD3 (17q21.1) / CDK12 (17q12)RARA (17q21.2) / CDK12 (17q12)TMEM104 (17q25.1) / CDK12 (17q12)
TUBD1 (17q23.1) / CDK12 (17q12)CDK12 17q12 / AKAP1 17q22CDK12 17q12 / FBXL20 17q12
CDK12 17q12 / JAK2 9p24.1CDK12 17q12 / SMG6 17p13.3ERBB2 17q12 / CDK12 17q12
MED1 17q12 / CDK12 17q12PDK2 17q21.33 / CDK12 17q12RARA 17q21.2 / CDK12 17q12
TUBD1 17q23.1 / CDK12 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 9 ]
  dup(17)(q12q21) PSMD3/CDK12
inv(17)(q12q25) CDK12/EIF4A3
t(9;17)(p24;q12) CDK12/JAK2
t(17;17)(p13;q12) CDK12/SMG6
t(17;17)(q12;q21) MSL1/CDK12
t(17;17)(q12;q21) PDK2/CDK12
t(17;17)(q12;q21) RARA/CDK12
t(17;17)(q12;q23) TUBD1/CDK12
t(17;17)(q12;q25) TMEM104/CDK12

External links

Nomenclature
HGNC (Hugo)CDK12   24224
Cards
Entrez_Gene (NCBI)CDK12  51755  cyclin dependent kinase 12
AliasesCRK7; CRKR; CRKRS
GeneCards (Weizmann)CDK12
Ensembl hg19 (Hinxton)ENSG00000167258 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167258 [Gene_View]  ENSG00000167258 [Sequence]  chr17:39461511-39534565 [Contig_View]  CDK12 [Vega]
ICGC DataPortalENSG00000167258
TCGA cBioPortalCDK12
AceView (NCBI)CDK12
Genatlas (Paris)CDK12
WikiGenes51755
SOURCE (Princeton)CDK12
Genetics Home Reference (NIH)CDK12
Genomic and cartography
GoldenPath hg38 (UCSC)CDK12  -     chr17:39461511-39534565 +  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK12  -     17q12   [Description]    (hg19-Feb_2009)
GoldenPathCDK12 - 17q12 [CytoView hg19]  CDK12 - 17q12 [CytoView hg38]
ImmunoBaseENSG00000167258
Mapping of homologs : NCBICDK12 [Mapview hg19]  CDK12 [Mapview hg38]
OMIM615514   
Gene and transcription
Genbank (Entrez)AB020711 AF227198 AK096059 AK302645 BC140854
RefSeq transcript (Entrez)NM_015083 NM_016507
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK12
Alternative Splicing GalleryENSG00000167258
Gene ExpressionCDK12 [ NCBI-GEO ]   CDK12 [ EBI - ARRAY_EXPRESS ]   CDK12 [ SEEK ]   CDK12 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51755
GTEX Portal (Tissue expression)CDK12
Human Protein AtlasENSG00000167258-CDK12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYV4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYV4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYV4
Splice isoforms : SwissVarQ9NYV4
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9NYV4
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK12
DMDM Disease mutations51755
Blocks (Seattle)CDK12
PDB (RSDB)4CXA    4NST    4UN0    5ACB    6B3E    6CKX   
PDB Europe4CXA    4NST    4UN0    5ACB    6B3E    6CKX   
PDB (PDBSum)4CXA    4NST    4UN0    5ACB    6B3E    6CKX   
PDB (IMB)4CXA    4NST    4UN0    5ACB    6B3E    6CKX   
Structural Biology KnowledgeBase4CXA    4NST    4UN0    5ACB    6B3E    6CKX   
SCOP (Structural Classification of Proteins)4CXA    4NST    4UN0    5ACB    6B3E    6CKX   
CATH (Classification of proteins structures)4CXA    4NST    4UN0    5ACB    6B3E    6CKX   
SuperfamilyQ9NYV4
Human Protein Atlas [tissue]ENSG00000167258-CDK12 [tissue]
Peptide AtlasQ9NYV4
HPRD10849
IPIIPI00021175   IPI00868781   IPI00910891   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYV4
IntAct (EBI)Q9NYV4
FunCoupENSG00000167258
BioGRIDCDK12
STRING (EMBL)CDK12
ZODIACCDK12
Ontologies - Pathways
QuickGOQ9NYV4
Ontology : AmiGOcyclin-dependent protein kinase holoenzyme complex  nuclear chromatin  cyclin K-CDK12 complex  protein kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  mRNA processing  protein phosphorylation  RNA polymerase II CTD heptapeptide repeat kinase activity  RNA polymerase II CTD heptapeptide repeat kinase activity  RNA splicing  nuclear speck  protein kinase binding  nuclear cyclin-dependent protein kinase holoenzyme complex  cyclin binding  positive regulation of transcription elongation from RNA polymerase II promoter  regulation of MAP kinase activity  regulation of RNA splicing  protein autophosphorylation  regulation of cell cycle  phosphorylation of RNA polymerase II C-terminal domain  phosphorylation of RNA polymerase II C-terminal domain  negative regulation of stem cell differentiation  
Ontology : EGO-EBIcyclin-dependent protein kinase holoenzyme complex  nuclear chromatin  cyclin K-CDK12 complex  protein kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  mRNA processing  protein phosphorylation  RNA polymerase II CTD heptapeptide repeat kinase activity  RNA polymerase II CTD heptapeptide repeat kinase activity  RNA splicing  nuclear speck  protein kinase binding  nuclear cyclin-dependent protein kinase holoenzyme complex  cyclin binding  positive regulation of transcription elongation from RNA polymerase II promoter  regulation of MAP kinase activity  regulation of RNA splicing  protein autophosphorylation  regulation of cell cycle  phosphorylation of RNA polymerase II C-terminal domain  phosphorylation of RNA polymerase II C-terminal domain  negative regulation of stem cell differentiation  
NDEx NetworkCDK12
Atlas of Cancer Signalling NetworkCDK12
Wikipedia pathwaysCDK12
Orthology - Evolution
OrthoDB51755
GeneTree (enSembl)ENSG00000167258
Phylogenetic Trees/Animal Genes : TreeFamCDK12
HOGENOMQ9NYV4
Homologs : HomoloGeneCDK12
Homology/Alignments : Family Browser (UCSC)CDK12
Gene fusions - Rearrangements
Fusion : MitelmanCDK12/EIF4A3 [17q12/17q25.3]  
Fusion : MitelmanCDK12/JAK2 [17q12/9p24.1]  [t(9;17)(p24;q12)]  
Fusion : MitelmanCDK12/SMG6 [17q12/17p13.3]  [t(17;17)(p13;q12)]  
Fusion : MitelmanPDK2/CDK12 [17q21.33/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanPSMD3/CDK12 [17q21.1/17q12]  [dup(17)(q12q21)]  
Fusion : MitelmanRARA/CDK12 [17q21.2/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanTMEM104/CDK12 [17q25.1/17q12]  [t(17;17)(q12;q25)]  
Fusion : MitelmanTUBD1/CDK12 [17q23.1/17q12]  [t(17;17)(q12;q23)]  
Fusion PortalCDK12 17q12 AKAP1 17q22 BRCA
Fusion PortalCDK12 17q12 FBXL20 17q12 BRCA
Fusion PortalCDK12 17q12 JAK2 9p24.1 BRCA
Fusion PortalCDK12 17q12 SMG6 17p13.3 OV
Fusion PortalERBB2 17q12 CDK12 17q12 BRCA
Fusion PortalMED1 17q12 CDK12 17q12 LUAD
Fusion PortalPDK2 17q21.33 CDK12 17q12 BRCA
Fusion PortalRARA 17q21.2 CDK12 17q12 BRCA
Fusion PortalTUBD1 17q23.1 CDK12 17q12 BRCA
Fusion : QuiverCDK12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK12
dbVarCDK12
ClinVarCDK12
1000_GenomesCDK12 
Exome Variant ServerCDK12
ExAC (Exome Aggregation Consortium)ENSG00000167258
GNOMAD BrowserENSG00000167258
Varsome BrowserCDK12
Genetic variants : HAPMAP51755
Genomic Variants (DGV)CDK12 [DGVbeta]
DECIPHERCDK12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK12 
Mutations
ICGC Data PortalCDK12 
TCGA Data PortalCDK12 
Broad Tumor PortalCDK12
OASIS PortalCDK12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDK12
Mutations and Diseases : HGMDCDK12
intOGen PortalCDK12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK12
DgiDB (Drug Gene Interaction Database)CDK12
DoCM (Curated mutations)CDK12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK12 (select a term)
intoGenCDK12
Cancer3DCDK12(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615514   
Orphanet
DisGeNETCDK12
MedgenCDK12
Genetic Testing Registry CDK12
NextProtQ9NYV4 [Medical]
TSGene51755
GENETestsCDK12
Target ValidationCDK12
Huge Navigator CDK12 [HugePedia]
snp3D : Map Gene to Disease51755
BioCentury BCIQCDK12
ClinGenCDK12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51755
Chemical/Pharm GKB GenePA165431656
Clinical trialCDK12
Miscellaneous
canSAR (ICR)CDK12 (select the gene name)
HarmonizomeCDK12
DataMed IndexCDK12
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK12
EVEXCDK12
GoPubMedCDK12
iHOPCDK12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 10 12:09:53 CEST 2020
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