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CDK13 (cyclin dependent kinase 13)

Identity

Alias_namesCDC2L5
cell division cycle 2-like 5 (cholinesterase-related cell division controller)
Alias_symbol (synonym)CHED
CDC2L
KIAA1791
Other aliasCHDFIDD
hCDK13
HGNC (Hugo) CDK13
LocusID (NCBI) 8621
Atlas_Id 40009
Location 7p14.1  [Link to chromosome band 7p14]
Location_base_pair Starts at 39950360 and ends at 40097134 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDK13 (7p14.1) / CDK13 (7p14.1)CDK13 (7p14.1) / PDZK1IP1 (1p33)CDK13 (7p14.1) / RALA (7p14.1)
CDK13 (7p14.1) / SMG7 (1q25.3)CDK13 (7p14.1) / TAX1BP1 (7p15.2)CDK13 (7p14.1) / YAE1D1 (7p14.1)
DDX50 (10q22.1) / CDK13 (7p14.1)CDK13 7p14.1 C7orf36CDK13 7p14.1 / TAX1BP1 7p15.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK13   1733
Cards
Entrez_Gene (NCBI)CDK13  8621  cyclin dependent kinase 13
AliasesCDC2L; CDC2L5; CHDFIDD; CHED; 
hCDK13
GeneCards (Weizmann)CDK13
Ensembl hg19 (Hinxton)ENSG00000065883 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065883 [Gene_View]  chr7:39950360-40097134 [Contig_View]  CDK13 [Vega]
ICGC DataPortalENSG00000065883
TCGA cBioPortalCDK13
AceView (NCBI)CDK13
Genatlas (Paris)CDK13
WikiGenes8621
SOURCE (Princeton)CDK13
Genetics Home Reference (NIH)CDK13
Genomic and cartography
GoldenPath hg38 (UCSC)CDK13  -     chr7:39950360-40097134 +  7p14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK13  -     7p14.1   [Description]    (hg19-Feb_2009)
EnsemblCDK13 - 7p14.1 [CytoView hg19]  CDK13 - 7p14.1 [CytoView hg38]
Mapping of homologs : NCBICDK13 [Mapview hg19]  CDK13 [Mapview hg38]
OMIM603309   617360   
Gene and transcription
Genbank (Entrez)AB058694 AJ297709 AJ297710 AK025500 AK092534
RefSeq transcript (Entrez)NM_003718 NM_031267
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK13
Cluster EST : UnigeneHs.233552 [ NCBI ]
CGAP (NCI)Hs.233552
Alternative Splicing GalleryENSG00000065883
Gene ExpressionCDK13 [ NCBI-GEO ]   CDK13 [ EBI - ARRAY_EXPRESS ]   CDK13 [ SEEK ]   CDK13 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK13 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8621
GTEX Portal (Tissue expression)CDK13
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14004   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14004  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14004
Splice isoforms : SwissVarQ14004
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusQ14004
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK13
DMDM Disease mutations8621
Blocks (Seattle)CDK13
PDB (SRS)5EFQ   
PDB (PDBSum)5EFQ   
PDB (IMB)5EFQ   
PDB (RSDB)5EFQ   
Structural Biology KnowledgeBase5EFQ   
SCOP (Structural Classification of Proteins)5EFQ   
CATH (Classification of proteins structures)5EFQ   
SuperfamilyQ14004
Human Protein AtlasENSG00000065883
Peptide AtlasQ14004
HPRD04496
IPIIPI00456970   IPI00029162   
Protein Interaction databases
DIP (DOE-UCLA)Q14004
IntAct (EBI)Q14004
FunCoupENSG00000065883
BioGRIDCDK13
STRING (EMBL)CDK13
ZODIACCDK13
Ontologies - Pathways
QuickGOQ14004
Ontology : AmiGOalternative mRNA splicing, via spliceosome  alternative mRNA splicing, via spliceosome  cyclin K-CDK13 complex  RNA binding  protein kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  extracellular region  extracellular space  nucleoplasm  chromosome  Golgi apparatus  cytosol  transcription elongation from RNA polymerase II promoter  regulation of mitotic nuclear division  multicellular organism development  cyclin/CDK positive transcription elongation factor complex  transcription factor binding  positive regulation of cell proliferation  RNA polymerase II carboxy-terminal domain kinase activity  viral process  nuclear speck  protein kinase binding  nuclear cyclin-dependent protein kinase holoenzyme complex  hemopoiesis  cyclin binding  neutrophil degranulation  transcription regulatory region DNA binding  positive regulation of transcription from RNA polymerase II promoter  phosphorylation of RNA polymerase II C-terminal domain  ficolin-1-rich granule lumen  negative regulation of stem cell differentiation  
Ontology : EGO-EBIalternative mRNA splicing, via spliceosome  alternative mRNA splicing, via spliceosome  cyclin K-CDK13 complex  RNA binding  protein kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  extracellular region  extracellular space  nucleoplasm  chromosome  Golgi apparatus  cytosol  transcription elongation from RNA polymerase II promoter  regulation of mitotic nuclear division  multicellular organism development  cyclin/CDK positive transcription elongation factor complex  transcription factor binding  positive regulation of cell proliferation  RNA polymerase II carboxy-terminal domain kinase activity  viral process  nuclear speck  protein kinase binding  nuclear cyclin-dependent protein kinase holoenzyme complex  hemopoiesis  cyclin binding  neutrophil degranulation  transcription regulatory region DNA binding  positive regulation of transcription from RNA polymerase II promoter  phosphorylation of RNA polymerase II C-terminal domain  ficolin-1-rich granule lumen  negative regulation of stem cell differentiation  
NDEx NetworkCDK13
Atlas of Cancer Signalling NetworkCDK13
Wikipedia pathwaysCDK13
Orthology - Evolution
OrthoDB8621
GeneTree (enSembl)ENSG00000065883
Phylogenetic Trees/Animal Genes : TreeFamCDK13
HOVERGENQ14004
HOGENOMQ14004
Homologs : HomoloGeneCDK13
Homology/Alignments : Family Browser (UCSC)CDK13
Gene fusions - Rearrangements
Fusion : MitelmanCDK13/TAX1BP1 [7p14.1/7p15.2]  
Fusion : MitelmanCDK13/YAE1D1 [7p14.1/7p14.1]  [t(7;7)(p14;p14)]  
Fusion: TCGACDK13 7p14.1 C7orf36 BRCA
Fusion: TCGACDK13 7p14.1 TAX1BP1 7p15.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK13 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK13
dbVarCDK13
ClinVarCDK13
1000_GenomesCDK13 
Exome Variant ServerCDK13
ExAC (Exome Aggregation Consortium)CDK13 (select the gene name)
Genetic variants : HAPMAP8621
Genomic Variants (DGV)CDK13 [DGVbeta]
DECIPHERCDK13 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK13 
Mutations
ICGC Data PortalCDK13 
TCGA Data PortalCDK13 
Broad Tumor PortalCDK13
OASIS PortalCDK13 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK13  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK13
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK13
DgiDB (Drug Gene Interaction Database)CDK13
DoCM (Curated mutations)CDK13 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK13 (select a term)
intoGenCDK13
Cancer3DCDK13(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603309    617360   
Orphanet
MedgenCDK13
Genetic Testing Registry CDK13
NextProtQ14004 [Medical]
TSGene8621
GENETestsCDK13
Target ValidationCDK13
Huge Navigator CDK13 [HugePedia]
snp3D : Map Gene to Disease8621
BioCentury BCIQCDK13
ClinGenCDK13
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8621
Chemical/Pharm GKB GenePA26264
Clinical trialCDK13
Miscellaneous
canSAR (ICR)CDK13 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK13
EVEXCDK13
GoPubMedCDK13
iHOPCDK13
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:27:44 CEST 2017

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