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CDK14 (cyclin dependent kinase 14)

Identity

Alias_namesPFTK1
PFTAIRE protein kinase 1
Alias_symbol (synonym)PFTAIRE1
Other alias
HGNC (Hugo) CDK14
LocusID (NCBI) 5218
Atlas_Id 43407
Location 7q21.13  [Link to chromosome band 7q21]
Location_base_pair Starts at 90596362 and ends at 91210590 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ABLIM3 (5q32) / CDK14 (7q21.13)AHR (7p21.1) / CDK14 (7q21.13)AKAP9 (7q21.2) / CDK14 (7q21.13)
CDK14 (7q21.13) / HS3ST4 (16p12.1)CDK14 (7q21.13) / MALAT1 (11q13.1)CDK14 (7q21.13) / MIPOL1 (14q13.3)
CDK14 (7q21.13) / PPP1CC (12q24.11)FGF13 (Xq26.3) / CDK14 (7q21.13)HCLS1 (3q13.33) / CDK14 (7q21.13)
KIF5A (12q13.3) / CDK14 (7q21.13)MAN2A1 (5q21.3) / CDK14 (7q21.13)OCLN (5q13.2) / CDK14 (7q21.13)
RBM47 (4p14) / CDK14 (7q21.13)UBR3 (2q31.1) / CDK14 (7q21.13)AHR 7p21.1 / CDK14 7q21.13
OCLN 5q13.2 / CDK14 7q21.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK14   8883
Cards
Entrez_Gene (NCBI)CDK14  5218  cyclin dependent kinase 14
AliasesPFTAIRE1; PFTK1
GeneCards (Weizmann)CDK14
Ensembl hg19 (Hinxton)ENSG00000058091 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000058091 [Gene_View]  chr7:90596362-91210590 [Contig_View]  CDK14 [Vega]
ICGC DataPortalENSG00000058091
TCGA cBioPortalCDK14
AceView (NCBI)CDK14
Genatlas (Paris)CDK14
WikiGenes5218
SOURCE (Princeton)CDK14
Genetics Home Reference (NIH)CDK14
Genomic and cartography
GoldenPath hg38 (UCSC)CDK14  -     chr7:90596362-91210590 +  7q21.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK14  -     7q21.13   [Description]    (hg19-Feb_2009)
EnsemblCDK14 - 7q21.13 [CytoView hg19]  CDK14 - 7q21.13 [CytoView hg38]
Mapping of homologs : NCBICDK14 [Mapview hg19]  CDK14 [Mapview hg38]
OMIM610679   
Gene and transcription
Genbank (Entrez)AA883846 AB020641 AF119833 AK289782 AK295086
RefSeq transcript (Entrez)NM_001287135 NM_001287136 NM_001287137 NM_012395
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK14
Cluster EST : UnigeneHs.740065 [ NCBI ]
CGAP (NCI)Hs.740065
Alternative Splicing GalleryENSG00000058091
Gene ExpressionCDK14 [ NCBI-GEO ]   CDK14 [ EBI - ARRAY_EXPRESS ]   CDK14 [ SEEK ]   CDK14 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5218
GTEX Portal (Tissue expression)CDK14
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94921   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94921  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94921
Splice isoforms : SwissVarO94921
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusO94921
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK14
DMDM Disease mutations5218
Blocks (Seattle)CDK14
SuperfamilyO94921
Human Protein AtlasENSG00000058091
Peptide AtlasO94921
HPRD15121
IPIIPI00165249   IPI00742856   IPI00877696   IPI00908349   IPI00878200   IPI00924750   IPI00954002   
Protein Interaction databases
DIP (DOE-UCLA)O94921
IntAct (EBI)O94921
FunCoupENSG00000058091
BioGRIDCDK14
STRING (EMBL)CDK14
ZODIACCDK14
Ontologies - Pathways
QuickGOO94921
Ontology : AmiGOG2/M transition of mitotic cell cycle  cytoplasmic cyclin-dependent protein kinase holoenzyme complex  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  protein phosphorylation  Wnt signaling pathway  cyclin binding  cell division  regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  cytoplasmic cyclin-dependent protein kinase holoenzyme complex  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  protein phosphorylation  Wnt signaling pathway  cyclin binding  cell division  regulation of canonical Wnt signaling pathway  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx NetworkCDK14
Atlas of Cancer Signalling NetworkCDK14
Wikipedia pathwaysCDK14
Orthology - Evolution
OrthoDB5218
GeneTree (enSembl)ENSG00000058091
Phylogenetic Trees/Animal Genes : TreeFamCDK14
HOVERGENO94921
HOGENOMO94921
Homologs : HomoloGeneCDK14
Homology/Alignments : Family Browser (UCSC)CDK14
Gene fusions - Rearrangements
Fusion : MitelmanAHR/CDK14 [7p21.1/7q21.13]  [t(7;7)(p21;q21)]  
Fusion : MitelmanOCLN/CDK14 [5q13.2/7q21.13]  [t(5;7)(q13;q21)]  
Fusion : MitelmanUBR3/CDK14 [2q31.1/7q21.13]  [t(2;7)(q31;q21)]  
Fusion: TCGAAHR 7p21.1 CDK14 7q21.13 BRCA
Fusion: TCGAOCLN 5q13.2 CDK14 7q21.13 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK14
dbVarCDK14
ClinVarCDK14
1000_GenomesCDK14 
Exome Variant ServerCDK14
ExAC (Exome Aggregation Consortium)CDK14 (select the gene name)
Genetic variants : HAPMAP5218
Genomic Variants (DGV)CDK14 [DGVbeta]
DECIPHERCDK14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK14 
Mutations
ICGC Data PortalCDK14 
TCGA Data PortalCDK14 
Broad Tumor PortalCDK14
OASIS PortalCDK14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK14
DgiDB (Drug Gene Interaction Database)CDK14
DoCM (Curated mutations)CDK14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK14 (select a term)
intoGenCDK14
Cancer3DCDK14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610679   
Orphanet
MedgenCDK14
Genetic Testing Registry CDK14
NextProtO94921 [Medical]
TSGene5218
GENETestsCDK14
Target ValidationCDK14
Huge Navigator CDK14 [HugePedia]
snp3D : Map Gene to Disease5218
BioCentury BCIQCDK14
ClinGenCDK14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5218
Chemical/Pharm GKB GenePA33221
Clinical trialCDK14
Miscellaneous
canSAR (ICR)CDK14 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK14
EVEXCDK14
GoPubMedCDK14
iHOPCDK14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:27:44 CEST 2017

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