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CDK16 (cyclin-dependent kinase 16)

Identity

Alias_namesPCTK1
PCTAIRE protein kinase 1
Alias_symbol (synonym)PCTAIRE
PCTAIRE1
PCTGAIRE
FLJ16665
Other alias
HGNC (Hugo) CDK16
LocusID (NCBI) 5127
Atlas_Id 43396
Location Xp11.23  [Link to chromosome band Xp11]
Location_base_pair Starts at 47082417 and ends at 47089394 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDK16 (Xp11.23) / CILP (15q22.31)CDK16 (Xp11.23) / PHF20 (20q11.22)CDK16 (Xp11.23) / USP9X (Xp11.4)
INTS9 (8p21.1) / CDK16 (Xp11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK16   8749
Cards
Entrez_Gene (NCBI)CDK16  5127  cyclin-dependent kinase 16
AliasesPCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1
GeneCards (Weizmann)CDK16
Ensembl hg19 (Hinxton)ENSG00000102225 [Gene_View]  chrX:47082417-47089394 [Contig_View]  CDK16 [Vega]
Ensembl hg38 (Hinxton)ENSG00000102225 [Gene_View]  chrX:47082417-47089394 [Contig_View]  CDK16 [Vega]
ICGC DataPortalENSG00000102225
TCGA cBioPortalCDK16
AceView (NCBI)CDK16
Genatlas (Paris)CDK16
WikiGenes5127
SOURCE (Princeton)CDK16
Genetics Home Reference (NIH)CDK16
Genomic and cartography
GoldenPath hg19 (UCSC)CDK16  -     chrX:47082417-47089394 +  Xp11.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CDK16  -     Xp11.23   [Description]    (hg38-Dec_2013)
EnsemblCDK16 - Xp11.23 [CytoView hg19]  CDK16 - Xp11.23 [CytoView hg38]
Mapping of homologs : NCBICDK16 [Mapview hg19]  CDK16 [Mapview hg38]
OMIM311550   
Gene and transcription
Genbank (Entrez)AB209465 AK096881 AK131486 AK290145 AK296880
RefSeq transcript (Entrez)NM_001170460 NM_006201 NM_033018
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_012517 NT_079573 NW_004929439
Consensus coding sequences : CCDS (NCBI)CDK16
Cluster EST : UnigeneHs.496068 [ NCBI ]
CGAP (NCI)Hs.496068
Alternative Splicing GalleryENSG00000102225
Gene ExpressionCDK16 [ NCBI-GEO ]   CDK16 [ EBI - ARRAY_EXPRESS ]   CDK16 [ SEEK ]   CDK16 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK16 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5127
GTEX Portal (Tissue expression)CDK16
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00536   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00536  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00536
Splice isoforms : SwissVarQ00536
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusQ00536
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK16
DMDM Disease mutations5127
Blocks (Seattle)CDK16
PDB (SRS)3MTL   
PDB (PDBSum)3MTL   
PDB (IMB)3MTL   
PDB (RSDB)3MTL   
Structural Biology KnowledgeBase3MTL   
SCOP (Structural Classification of Proteins)3MTL   
CATH (Classification of proteins structures)3MTL   
SuperfamilyQ00536
Human Protein AtlasENSG00000102225
Peptide AtlasQ00536
HPRD02409
IPIIPI00549858   IPI00922194   IPI01014193   IPI00954838   IPI00981436   IPI00910421   IPI00978045   IPI00973980   IPI00977843   IPI00984131   IPI00976684   IPI01012281   IPI00976021   IPI00978758   IPI00979975   
Protein Interaction databases
DIP (DOE-UCLA)Q00536
IntAct (EBI)Q00536
FunCoupENSG00000102225
BioGRIDCDK16
STRING (EMBL)CDK16
ZODIACCDK16
Ontologies - Pathways
QuickGOQ00536
Ontology : AmiGOprotein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  plasma membrane  protein phosphorylation  exocytosis  spermatogenesis  synaptic vesicle  microtubule cytoskeleton  cell junction  growth hormone secretion  neuron projection development  extrinsic component of cytoplasmic side of plasma membrane  neuron projection  regulation of cell cycle  regulation of insulin secretion involved in cellular response to glucose stimulus  
Ontology : EGO-EBIprotein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  plasma membrane  protein phosphorylation  exocytosis  spermatogenesis  synaptic vesicle  microtubule cytoskeleton  cell junction  growth hormone secretion  neuron projection development  extrinsic component of cytoplasmic side of plasma membrane  neuron projection  regulation of cell cycle  regulation of insulin secretion involved in cellular response to glucose stimulus  
NDEx NetworkCDK16
Atlas of Cancer Signalling NetworkCDK16
Wikipedia pathwaysCDK16
Orthology - Evolution
OrthoDB5127
GeneTree (enSembl)ENSG00000102225
Phylogenetic Trees/Animal Genes : TreeFamCDK16
HOVERGENQ00536
HOGENOMQ00536
Homologs : HomoloGeneCDK16
Homology/Alignments : Family Browser (UCSC)CDK16
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK16 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK16
dbVarCDK16
ClinVarCDK16
1000_GenomesCDK16 
Exome Variant ServerCDK16
ExAC (Exome Aggregation Consortium)CDK16 (select the gene name)
Genetic variants : HAPMAP5127
Genomic Variants (DGV)CDK16 [DGVbeta]
DECIPHER (Syndromes)X:47082417-47089394  ENSG00000102225
CONAN: Copy Number AnalysisCDK16 
Mutations
ICGC Data PortalCDK16 
TCGA Data PortalCDK16 
Broad Tumor PortalCDK16
OASIS PortalCDK16 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK16  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK16
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch CDK16
DgiDB (Drug Gene Interaction Database)CDK16
DoCM (Curated mutations)CDK16 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK16 (select a term)
intoGenCDK16
Cancer3DCDK16(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM311550   
Orphanet
MedgenCDK16
Genetic Testing Registry CDK16
NextProtQ00536 [Medical]
TSGene5127
GENETestsCDK16
Huge Navigator CDK16 [HugePedia]
snp3D : Map Gene to Disease5127
BioCentury BCIQCDK16
ClinGenCDK16
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5127
Chemical/Pharm GKB GenePA33095
Clinical trialCDK16
Miscellaneous
canSAR (ICR)CDK16 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK16
EVEXCDK16
GoPubMedCDK16
iHOPCDK16
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:55:56 CEST 2017

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