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CDK18 (cyclin dependent kinase 18)

Identity

Alias_namesPCTK3
PCTAIRE protein kinase 3
Alias_symbol (synonym)PCTAIRE3
Other aliasPCTAIRE
HGNC (Hugo) CDK18
LocusID (NCBI) 5129
Atlas_Id 43398
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 205504556 and ends at 205532793 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATP2A2 (12q24.11) / CDK18 (1q32.1)CACNA1G (17q21.33) / CDK18 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK18   8751
Cards
Entrez_Gene (NCBI)CDK18  5129  cyclin dependent kinase 18
AliasesPCTAIRE; PCTAIRE3; PCTK3
GeneCards (Weizmann)CDK18
Ensembl hg19 (Hinxton)ENSG00000117266 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117266 [Gene_View]  chr1:205504556-205532793 [Contig_View]  CDK18 [Vega]
ICGC DataPortalENSG00000117266
TCGA cBioPortalCDK18
AceView (NCBI)CDK18
Genatlas (Paris)CDK18
WikiGenes5129
SOURCE (Princeton)CDK18
Genetics Home Reference (NIH)CDK18
Genomic and cartography
GoldenPath hg38 (UCSC)CDK18  -     chr1:205504556-205532793 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK18  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblCDK18 - 1q32.1 [CytoView hg19]  CDK18 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBICDK18 [Mapview hg19]  CDK18 [Mapview hg38]
OMIM169190   
Gene and transcription
Genbank (Entrez)AB209307 AK126879 AK293756 AK295272 AK295654
RefSeq transcript (Entrez)NM_002596 NM_212502 NM_212503
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK18
Cluster EST : UnigeneHs.445402 [ NCBI ]
CGAP (NCI)Hs.445402
Alternative Splicing GalleryENSG00000117266
Gene ExpressionCDK18 [ NCBI-GEO ]   CDK18 [ EBI - ARRAY_EXPRESS ]   CDK18 [ SEEK ]   CDK18 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5129
GTEX Portal (Tissue expression)CDK18
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07002   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07002  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07002
Splice isoforms : SwissVarQ07002
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusQ07002
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK18
DMDM Disease mutations5129
Blocks (Seattle)CDK18
SuperfamilyQ07002
Human Protein AtlasENSG00000117266
Peptide AtlasQ07002
HPRD01354
IPIIPI00914963   IPI00394661   IPI00414292   IPI01016060   IPI00910567   IPI00383457   IPI00982233   IPI00964605   IPI00963874   IPI00966510   IPI00644054   IPI00966117   
Protein Interaction databases
DIP (DOE-UCLA)Q07002
IntAct (EBI)Q07002
FunCoupENSG00000117266
BioGRIDCDK18
STRING (EMBL)CDK18
ZODIACCDK18
Ontologies - Pathways
QuickGOQ07002
Ontology : AmiGOprotein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  cellular_component  nucleus  cytoplasm  protein phosphorylation  
Ontology : EGO-EBIprotein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  cellular_component  nucleus  cytoplasm  protein phosphorylation  
NDEx NetworkCDK18
Atlas of Cancer Signalling NetworkCDK18
Wikipedia pathwaysCDK18
Orthology - Evolution
OrthoDB5129
GeneTree (enSembl)ENSG00000117266
Phylogenetic Trees/Animal Genes : TreeFamCDK18
HOVERGENQ07002
HOGENOMQ07002
Homologs : HomoloGeneCDK18
Homology/Alignments : Family Browser (UCSC)CDK18
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK18
dbVarCDK18
ClinVarCDK18
1000_GenomesCDK18 
Exome Variant ServerCDK18
ExAC (Exome Aggregation Consortium)CDK18 (select the gene name)
Genetic variants : HAPMAP5129
Genomic Variants (DGV)CDK18 [DGVbeta]
DECIPHERCDK18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK18 
Mutations
ICGC Data PortalCDK18 
TCGA Data PortalCDK18 
Broad Tumor PortalCDK18
OASIS PortalCDK18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK18
DgiDB (Drug Gene Interaction Database)CDK18
DoCM (Curated mutations)CDK18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK18 (select a term)
intoGenCDK18
Cancer3DCDK18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM169190   
Orphanet
MedgenCDK18
Genetic Testing Registry CDK18
NextProtQ07002 [Medical]
TSGene5129
GENETestsCDK18
Target ValidationCDK18
Huge Navigator CDK18 [HugePedia]
snp3D : Map Gene to Disease5129
BioCentury BCIQCDK18
ClinGenCDK18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5129
Chemical/Pharm GKB GenePA33097
Clinical trialCDK18
Miscellaneous
canSAR (ICR)CDK18 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK18
EVEXCDK18
GoPubMedCDK18
iHOPCDK18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:01:41 CEST 2017

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