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CDK19 (cyclin dependent kinase 19)

Identity

Alias (NCBI)CDC2L6
CDK11
EIEE87
bA346C16.3
HGNC (Hugo) CDK19
HGNC Alias symbKIAA1028
bA346C16.3
HGNC Previous nameCDK11
 CDC2L6
HGNC Previous namecyclin-dependent kinase (CDC2-like) 11
 cell division cycle 2-like 6 (CDK8-like)
LocusID (NCBI) 23097
Atlas_Id 51315
Location 6q21  [Link to chromosome band 6q21]
Location_base_pair Starts at 110609978 and ends at 110815469 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDK19 (6q21) / CDK19 (6q21)CDK19 (6q21) / USP14 (18p11.32)CDK19 (6q21) / ZFAND3 (6p21.2)
MNT (17p13.3) / CDK19 (6q21)OAF (11q23.3) / CDK19 (6q21)SYNCRIP (6q14.3) / CDK19 (6q21)
SYNJ2 (6q25.3) / CDK19 (6q21)CDK19 6q21 / ZFAND3 6p21.2SYNCRIP 6q14.3 / CDK19 6q21
SYNJ2 6q25.3 / CDK19 6q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(6;6)(p21;q21) CDK19/ZFAND3
t(6;6)(q14;q21) SYNCRIP/CDK19
t(6;6)(q21;q25) SYNJ2/CDK19

External links

Nomenclature
HGNC (Hugo)CDK19   19338
Cards
Entrez_Gene (NCBI)CDK19    cyclin dependent kinase 19
AliasesCDC2L6; CDK11; EIEE87; bA346C16.3
GeneCards (Weizmann)CDK19
Ensembl hg19 (Hinxton)ENSG00000155111 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155111 [Gene_View]  ENSG00000155111 [Sequence]  chr6:110609978-110815469 [Contig_View]  CDK19 [Vega]
ICGC DataPortalENSG00000155111
TCGA cBioPortalCDK19
AceView (NCBI)CDK19
Genatlas (Paris)CDK19
SOURCE (Princeton)CDK19
Genetics Home Reference (NIH)CDK19
Genomic and cartography
GoldenPath hg38 (UCSC)CDK19  -     chr6:110609978-110815469 -  6q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK19  -     6q21   [Description]    (hg19-Feb_2009)
GoldenPathCDK19 - 6q21 [CytoView hg19]  CDK19 - 6q21 [CytoView hg38]
ImmunoBaseENSG00000155111
genome Data Viewer NCBICDK19 [Mapview hg19]  
OMIM614720   618916   
Gene and transcription
Genbank (Entrez)AB028951 AJ420571 AK292360 AK300567 AL122055
RefSeq transcript (Entrez)NM_001300960 NM_001300963 NM_001300964 NM_015076
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK19
Alternative Splicing GalleryENSG00000155111
Gene ExpressionCDK19 [ NCBI-GEO ]   CDK19 [ EBI - ARRAY_EXPRESS ]   CDK19 [ SEEK ]   CDK19 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK19 [ Firebrowse - Broad ]
GenevisibleExpression of CDK19 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23097
GTEX Portal (Tissue expression)CDK19
Human Protein AtlasENSG00000155111-CDK19 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BWU1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BWU1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BWU1
Splice isoforms : SwissVarQ9BWU1
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9BWU1
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK19
Blocks (Seattle)CDK19
SuperfamilyQ9BWU1
Human Protein Atlas [tissue]ENSG00000155111-CDK19 [tissue]
Peptide AtlasQ9BWU1
HPRD07627
IPIIPI00250316   IPI00170593   IPI00909706   IPI00646406   IPI00983902   
Protein Interaction databases
DIP (DOE-UCLA)Q9BWU1
IntAct (EBI)Q9BWU1
BioGRIDCDK19
STRING (EMBL)CDK19
ZODIACCDK19
Ontologies - Pathways
QuickGOQ9BWU1
Ontology : AmiGOcyclin-dependent protein serine/threonine kinase activity  ATP binding  nucleus  cytosol  protein phosphorylation  RNA polymerase II CTD heptapeptide repeat kinase activity  mediator complex  positive regulation of apoptotic process  positive regulation of inflammatory response  regulation of cell cycle  cellular response to lipopolysaccharide  
Ontology : EGO-EBIcyclin-dependent protein serine/threonine kinase activity  ATP binding  nucleus  cytosol  protein phosphorylation  RNA polymerase II CTD heptapeptide repeat kinase activity  mediator complex  positive regulation of apoptotic process  positive regulation of inflammatory response  regulation of cell cycle  cellular response to lipopolysaccharide  
NDEx NetworkCDK19
Atlas of Cancer Signalling NetworkCDK19
Wikipedia pathwaysCDK19
Orthology - Evolution
OrthoDB23097
GeneTree (enSembl)ENSG00000155111
Phylogenetic Trees/Animal Genes : TreeFamCDK19
HOGENOMQ9BWU1
Homologs : HomoloGeneCDK19
Homology/Alignments : Family Browser (UCSC)CDK19
Gene fusions - Rearrangements
Fusion : MitelmanCDK19/ZFAND3 [6q21/6p21.2]  
Fusion : MitelmanSYNCRIP/CDK19 [6q14.3/6q21]  
Fusion : MitelmanSYNJ2/CDK19 [6q25.3/6q21]  
Fusion PortalCDK19 6q21 ZFAND3 6p21.2 BRCA
Fusion PortalSYNCRIP 6q14.3 CDK19 6q21 BRCA
Fusion PortalSYNJ2 6q25.3 CDK19 6q21 BRCA
Fusion : QuiverCDK19
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK19 [hg38]
dbVarCDK19
ClinVarCDK19
MonarchCDK19
1000_GenomesCDK19 
Exome Variant ServerCDK19
GNOMAD BrowserENSG00000155111
Varsome BrowserCDK19
Genomic Variants (DGV)CDK19 [DGVbeta]
DECIPHERCDK19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK19 
Mutations
ICGC Data PortalCDK19 
TCGA Data PortalCDK19 
Broad Tumor PortalCDK19
OASIS PortalCDK19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK19  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDK19
Mutations and Diseases : HGMDCDK19
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK19
DgiDB (Drug Gene Interaction Database)CDK19
DoCM (Curated mutations)CDK19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK19 (select a term)
intoGenCDK19
Cancer3DCDK19(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614720    618916   
Orphanet
DisGeNETCDK19
MedgenCDK19
Genetic Testing Registry CDK19
NextProtQ9BWU1 [Medical]
GENETestsCDK19
Target ValidationCDK19
Huge Navigator CDK19 [HugePedia]
ClinGenCDK19
Clinical trials, drugs, therapy
MyCancerGenomeCDK19
Protein Interactions : CTD
Pharm GKB GenePA165617767
PharosQ9BWU1
Clinical trialCDK19
Miscellaneous
canSAR (ICR)CDK19 (select the gene name)
HarmonizomeCDK19
DataMed IndexCDK19
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCDK19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:09:23 CET 2021
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